Abstract: The present invention relates to a series of genes the expression of which is altered in subjects suffering multiple sclerosis with respect to healthy subjects or in subjects suffering multiple sclerosis with a good prognosis with respect to subjects suffering multiple sclerosis with a bad prognosis. A subset formed by 13 genes and two clinical variables which allows predicting the progress of a patient with a high reliability has been validated from an initial set of genes which showed said differential expression. From said expression values, the invention provides methods for predicting the progress of a patient diagnosed with multiple sclerosis from tables of conditional probability between the expression levels of a determined gene or group of genes and the probability that the patient has a good or bad prognosis of the disease.
Type:
Application
Filed:
December 18, 2008
Publication date:
July 18, 2013
Applicants:
INSTITUTO CIENTIFICO Y TECNOLOGICO DE NAVARRA, S.A, PROGENIKA BIOPHARMA, S.A.
Inventors:
Pablo Villoslada Díaz, Ricardo Palacios Urtasun, Jorge Sepulcre Bernad, Laureano Simón Buela, Antonio Martínez Martínez
Abstract: The invention relates to an electrode-bearing guide, a cochlear implant comprising said guide and the production method thereof. According to the invention, the long and essentially flat guide comprises a plurality of electrodes (2) which are connected to corresponding contacts (3) by means of tracks (4). The inventive guide also comprises at least two stacked basic cells (CB1, CB2, . . . CB11), each of said cells comprising an insulating base layer (11). Moreover, a conductive layer (12) is disposed on top of the aforementioned insulating layer and forms the electrodes (2), the tracks (4) and the contacts (3). The production method consists in successively stacking insulating and conductive layers and defining suitable shapes by means of photolithography in order to form electrodes, contacts, tracks and windows for accessing the electrodes and contacts.
Type:
Grant
Filed:
December 15, 2003
Date of Patent:
April 24, 2012
Assignee:
Instituto Cientifico y Tecnologico de Navarra, S.A.
Inventors:
Manuel Manrique Rodriguez, Francisco Javier Gracia Gaudo
Abstract: The invention relates to nanoparticles comprising a biodegradable polymer, a cyclodextrin or a derivative thereof, and a biologically active molecule. Said nanoparticles can associate large amounts of biologically active molecules, especially of a hydrophobic nature, and release the biologically active molecule providing sustained and constant plasma levels thereof when they are administered orally or through any other mucosa of the organism.
Type:
Application
Filed:
April 18, 2008
Publication date:
June 3, 2010
Applicant:
INSTITUTO CIENTÍFICO Y TECNOLÓGICO DE NAVARRA, S.A
Inventors:
Maite Agüeros Bazo, Hesham H.A. Salman, Juan Manuel Irache Garreta, Miguel Angel Campanero Martínez