Abstract: The present invention relates to novel methods for combating cell degeneration or dysfunction resulting from neuroinflammatory conditions. The invention especially relates to the use, in the preparation of a medicament for the treatment of neurodegenerative disease associated with neuroinflammation, of an immunogenic compound which is capable of inducing an immune response against a proapoptotic neurotrophin, or an effective amount of a hapten combined with appropriate carriers and/or adjuvants to render the resulting combination capable of inducing an immune response against a proapoptotic neurotrophin. Also disclosed are compositions for the active or passive immunization against neuronal or glial cell apoptosis caused by neuroinflammation as well as methods and means useful for said active or passive immunization.
Type:
Application
Filed:
December 24, 2009
Publication date:
July 22, 2010
Applicants:
INSTITUT PASTEUR, INSTITUTO DE INVEST. BIO. CLEMENTE ESTABLE
Inventors:
Luis Hector Barbeito, Alvaro G. Estevez, Joseph S. Beckman, Mariana Pehar, Pedro Alzari, Maria Patricia Cassina
Abstract: The present invention relates to novel methods for combating cell degeneration or dysfunction resulting from neuroinflammatory conditions. The invention especially relates to the use, in the preparation of a medicament for the treatment of neurodegenerative disease associated with neuroinflammation, of an immunogenic compound which is capable of inducing an immune response against a proapoptotic neurotrophin, or an effective amount of a hapten combined with appropriate carriers and/or adjuvants to render the resulting combination capable of inducing an immune response against a proapoptotic neurotrophin. Also disclosed are compositions for the active or passive immunization against neuronal or glial cell apoptosis caused by neuroinflammation as well as methods and means useful for said active or passive immunization.
Type:
Application
Filed:
January 24, 2006
Publication date:
December 7, 2006
Applicants:
INSTITUT PASTEUR, INSTITUTO DE INVEST. BIO. CLEMENTE ESTABLE
Inventors:
Luis Barbeito, Alvaro Estevez, Joseph Beckman, Mariana Pehar, Pedro Alzari, Maria Cassina