Patents Assigned to Instituto de Investigacion y Desarrolo Quimico Biologico, S.A.
  • Cyclopropyl derivatives, preparation method there-of and applications
    Patent number: 5834490
    Abstract: Cyclopropyl derivatives of formula (I) wherein R is cyclopropyl or methyllopropyl are prepared by reaction of 2,6-dibromohexanoyl chloride with 2,6-dimethylaniline in the presence of a base at 0.degree.-25.degree. C. to give 2,6-dibromohexanoyl-2,6-dimethylanilide which subsequently is reacted with R--NH.sub.2 (wherein R is cyclopropyl or methylcyclopropyl) at 70.degree.-100.degree. C. The compounds are useful as antiarrhythmic agents and as local anaesthetic agents.
    Type: Grant
    Filed: August 15, 1997
    Date of Patent: November 10, 1998
    Assignee: Instituto de Investigacion y Desarrolo Quimico Biologico, S.A.
    Inventors: Maria Jose Verde-Casanova, Alvaro Galiano-Ramos