Patents Assigned to Instituto de Medicina Molecular João Lobo Antunes
  • Genetic Construct
    Publication number: 20230313229
    Abstract: The invention relates to genetic constructs comprising at least one microRNA target site, and vectors comprising such constructs. The genetic constructs and vectors can be used in diagnosis and therapy of a range of disorders, including cancers, for example T-cell acute lymphoblastic leukaemia (T-ALL).
    Type: Application
    Filed: August 25, 2021
    Publication date: October 5, 2023
    Applicant: Instituto de Medicina Molecular João Lobo Antunes
    Inventors: Ana Rita Freitas Martins de Matos FRAGOSO, João Pedro Taborda BARATA
  • TRPV2 antagonists
    Patent number: 11273152
    Abstract: This invention relates to the finding that Piperlongumine compounds, such as Piperlongumine and analogues, derivatives and prodrugs thereof, are reversible, allosteric antagonists of transient receptor potential vanilloid 2 channel (TRPV2). Methods of treatment of conditions that are characterised by TRPV2 expression using Piperlongumine compounds and Piperlongumine compounds for use in such treatments are provided.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: March 15, 2022
    Assignee: Instituto de Medicina Molecular João Lobo Antunes
    Inventors: Goncalo Bernardes, Tiago Rodrigues, João Conde, Charlotte Baker