Patents Assigned to Instituto di Ricerche di Biologia Molecolare P. Angelett S.P.A.
  • Mutant interleukin 6 with improved biological activity over wild interleukin 6
    Patent number: 5681723
    Abstract: The present invention is drawn to mutant interleukin 6, which has the amino acid arginine in position 176, replacing serine in position 176 with wild-type interleukin 6. The mutant interleukin 6 of the present invention has greater biological activity than the wild-type protein. The present invention is further drawn to methods of making mutant interleukin 6, having arginine at position 176 and methods of using the same.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: October 28, 1997
    Assignee: Instituto di Ricerche di Biologia Molecolare P. Angelett S.P.A.
    Inventors: Gennaro Ciliberto, Rocco Savino