Abstract: A novel polymorphism in the human PC-1 gene is characterized, which is associated with an increased predisposition to developing insulin resistance. The polymorphism affects heterozygous and homozygous carriers of the allele. The subject nucleic acids and fragments thereof, encoded polypeptides, and antibodies specific for the polymorphic amino acid sequence are useful in determining a genetic predisposition to insulin resistance. The encoded protein is useful in drug screening for compositions that affect the activity of PC-1 and insulin receptor activity or expression.
Type:
Grant
Filed:
November 18, 1999
Date of Patent:
October 15, 2002
Assignees:
Instituto di Ricovero e Cura a Carattere Scientifico, The Regents of the University of California
Inventors:
Ira Goldfine, Vincenzo Trischitta, Riccardo Vigneri, Antonio Pizzuti, Lucia A. Frittitta