Patents Assigned to Instituto Nacional de Technologia Agropecuaria
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Patent number: 11325965Abstract: Isolated VHH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I Norovirus or a Genogroup II Norovirus. In other embodiments, the Norovirus is Norwalk or MD2004 virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. Also disclosed are methods of treating and/or preventing a NoV infection.Type: GrantFiled: April 21, 2020Date of Patent: May 10, 2022Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Instituto Nacional De Technologia AgropecuariaInventors: Karin Bok, Lorena Laura Garaicoechea, Viviana Parreno, Andrea Pamela Aguilar, Marina Bok, Lisbeth Kim Green, Stanislav Vladimirovich Sosnovtsev
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Patent number: 10662238Abstract: Isolated VHH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I Norovirus or a Genogroup II Norovirus. In other embodiments, the Norovirus is Norwalk or MD2004 virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. Also disclosed are methods of treating and/or preventing a NoV infection.Type: GrantFiled: May 17, 2018Date of Patent: May 26, 2020Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Instituto Nacional De Technologia AgropecuariaInventors: Karin Bok, Lorena Laura Garaicoechea, Viviana Parreno, Andrea Pamela Aguilar, Marina Bok, Lisbeth Kim Green, Stanislav Vladimirovich Sosnovtsev
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Patent number: 10029006Abstract: The invention relates to recombinant bovine leukemia viruses that have an attenuated phenotype and comprise a combination of at least two specific mutations. The invention also provides recombinant nucleic acids encoding such viruses, vectors comprising such nucleic acids, and host cells comprising such nucleic acids or vectors. The recombinant attenuated BLV viruses, recombinant nucleic acids, vectors and host cells allow for the preparation of improved vaccines, in particular vaccines suitable for the prophylactic treatment of BLV-associated diseases in subjects. The invention further provides methods for treating BLV-associated diseases in subjects and pharmaceutical compositions suitable for use in these methods.Type: GrantFiled: August 21, 2015Date of Patent: July 24, 2018Assignee: INSTITUTO NACIONAL DE TECHNOLOGÍA AGROPECUARIAInventors: Luc Willems, Karina Trono
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Patent number: 10000556Abstract: Isolated VHH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I Norovirus or a Genogroup II Norovirus. In other embodiments, the Norovirus is Norwalk or MD2004 virus. In some embodiments, the monoclonal antibodies specifically bind VP1. Also disclosed are compositions including the disclosed antibodies, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of a Norovirus in a biological sample, or detecting a Norovirus infection. Also disclosed are methods of treating and/or preventing a NoV infection.Type: GrantFiled: May 9, 2014Date of Patent: June 19, 2018Assignees: THE UNITED STATES OF AMERICA, as represented by the Secretary, Dept. of Health and Human Services, INSTITUTO NACIONAL DE TECHNOLOGIA AGROPECUARIAInventors: Karin Bok, Lorena Laura Garaicoechea, Viviana Parreno, Andrea Pamela Aguilar, Marina Bok, Lisbeth Kim Green, Stanislav Vladimirovich Sosnovtsev
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Patent number: 9371373Abstract: Monomeric VHH domain derived from anti-VP6 camelid antibodies, dimeric domain, immunization method, and treatment method for rotavirus infections, wherein said domain may be any of the amino acid sequences shown in SEQ ID NO:1, SEQ ID NO:2 or SEQ ID NO:3, and wherein said domains bind to protein VP6 of Group A rotavirus.Type: GrantFiled: December 3, 2013Date of Patent: June 21, 2016Assignee: INSTITUTO NACIONAL DE TECHNOLOGIA AGROPECUARIA (INTA)Inventors: Thomas Surrey, Aurelien Olichon, Lorena Laura Garaicoeachea, Gisela Ariana Marcoppido, Gladys Viviana Parreño, Silvia Gómez Sebastián, José Angel Martínez Escribano, Andrés Wigdorovitz
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Publication number: 20070234696Abstract: A drag-type cotton harvester operated by an independent driving unit, which comprises a stripper-type cotton picker platform having a series of fingers that are aligned parallel to the forward direction of the machine, wherein the front ends of the fingers are close to ground level and the back ends thereof are ramped in an upward direction; a cleaning apparatus that receives the picked cotton from the picker platform, which cleaning apparatus comprises a set of rotary dentate cylinders that engage the cotton and remove the heavy masses or impurities therefrom, while a rotary brush that is disposed tangential to the dentate cylinders disengages the clean cotton from the aforementioned fingers; and a trailer that receives the clean cotton from the cleaning apparatus, then stores it and transports it.Type: ApplicationFiled: March 30, 2007Publication date: October 11, 2007Applicant: Instituto Nacional De Technologia AgropecuariaInventor: Orlando Pilatti
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Publication number: 20070028318Abstract: The present invention is directed to plants having increased tolerance to an imidazolinone herbicide. More particularly, the present invention includes rice plants containing at least one variant AHAS nucleic acid such as an imidazolinone tolerant IMINTA 1, 4 or 5 lines comprising an alanine to threonine substitution as compared to the wild-type AHAS. The present invention also includes seeds produced by these rice plants and methods of controlling weeds in the vicinity of these rice plants.Type: ApplicationFiled: August 30, 2004Publication date: February 1, 2007Applicant: Instituto Nacional de Technologia AgropecuariaInventors: Alberto Livore, Alberto Prina, Iwona Birk, Bijay Singh