Patents Assigned to Instituto Nazionale per Lo Studio e La Cura Dei Tumori
  • Camptothecins conjugated in position 7 to cyclic peptides as cytostatic agents
    Patent number: 7705012
    Abstract: Compounds of Formula (I) are described in which the R1 group is as defined in the specification and includes the condensation of the camptothecin molecule in position 7 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors ?v?3 and ?v?5 and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: April 27, 2010
    Assignees: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Instituto Nazionale per lo Studio e la Cura Dei Tumori
    Inventors: Claudio Pisano, Giuseppe Giannini, Maria Ornella Tinti, Loredana Vesci, Domenico Alloatti, Sergio Penco, Alma Dal Pozzo, Ni Minghong, Sabrina Dallavalle, Lucio Merlini, Franco Zunino
  • Antitumor uses of compound
    Publication number: 20090130229
    Abstract: The use of an arylidene 2-indolinone derivative for treating tumors involving Met, PDGF-R, FGF-RI, FGF-R3 or Kit tyrosine kinases, or a Ret oncoprotein which includes a MEN2-associated mutation is disclosed.
    Type: Application
    Filed: November 13, 2008
    Publication date: May 21, 2009
    Applicants: Cell Therapeutics, Inc., Instituto Nazionale per lo Studio e la Cura dei Tumori
    Inventors: Cinzia Lanzi, Giuliana Cassinelli, Giuditta Cuccuru, Marco A. Pierotti, Franco Zunino, Ernesto Menta
  • Camptothecins with a modified lactone ring
    Patent number: 7273873
    Abstract: Compounds of formula (I) or (II) are described: where the groups are as defined in the description here below, the racemic mixtures, their individual enantiomers, their individual diastereoisomers, their mixtures, and their pharmaceutically acceptable salts. Said compounds are topoisomerase I inhibitors.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: September 25, 2007
    Assignees: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Instituto Nazionale per Lo Studio e La Cura Dei Tumori
    Inventors: Mauro Marzi, Elena Marastoni, Claudio Pisano, Maria Ornella Tinti, Cabri Walter, Alpegiani Marco, Vergani Domenico, Danelli Tamara, Gomez Patricio Martin, Vesci Loredana, Zunino Franco, Penco Sergio
  • Method for the detection of cancer
    Publication number: 20070148644
    Abstract: A method for the early diagnosis, prognosis or clinical monitoring of cancer disease based on the quantitation of DNA in a plasma sample from a cancer patient, a subject with cancer susceptibility or an individual at risk of developing cancer.
    Type: Application
    Filed: December 22, 2003
    Publication date: June 28, 2007
    Applicant: INSTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI
    Inventor: Gabriella Sozzi
  • Method of treating cancer with a fully myeloablative regimen of chemotherapy, radiation or both
    Patent number: 5649904
    Abstract: The use, in sequence, of a cytotoxic, but stem cell sparing, agent and granulocyte-macrophage colony stimulating factor as a means to harvest very high numbers of multipotential haemopoietic precursor cells and in reducing the period of myeloid recovery after high dose chemo- or radiotherapy of cancer.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: July 22, 1997
    Assignees: Sandoz Ltd., Instituto Nazionale Per Lo Studio E La Cura Dei Tumori
    Inventor: Alessandro M. Gianni