Abstract: The present invention is related to use of marimastat or a pharmaceutically acceptable salt, solvate or polymorph thereof in preventing or treating epileptogenesis in a subject that suffered a brain insult. Said brain insult is a stroke, traumatic brain injury, or a result of status epilepticus, evoked by structural or metabolic reasons. Marimastat or a pharmaceutically acceptable salt thereof is administered preferably within the first 24 hours after induction of epileptogenesis.
Type:
Application
Filed:
June 17, 2019
Publication date:
November 3, 2022
Applicants:
Instytut Biologii Doswiadczalnej Im. Marcelego Nenckiego Polska Akademia Nauk, Uniwersytet Warszawski
Inventors:
Leszek Kaczmarek, Barbara Pijet-Binkiewicz, Anna Konopka, Emilia Rejmak-Kozicka
Abstract: The present invention relates to panels of biomarker microRNAs for use in methods of diagnosing Alzheimer's disease and related diseases and conditions in a subject. The methods involve assessing the level of said biomarker microRNA(s) in subject blood sample. The invention also relates to kits comprising said panels of biomarker microRNAs, methods of diagnosing Alzheimer's disease and to the use of said panels of biomarker microRNAs in diagnosis.
Type:
Application
Filed:
April 25, 2017
Publication date:
May 9, 2019
Applicants:
Instytut Biologii Doswiadczalnej im. Marcelego Nenckiego Polska Akademia Nauk, Biotech Innovations SpĆ³lka z Ograniczona Odpowiedziainoscia
Inventors:
Urszula Wojda, Katarzyna Laskowska-Kaszub, Tomasz Gabryelewicz, Jacek Kuznicki