Abstract: A medical application of N-oleoyl-dopamine and 3?-O-methyl-N-oleoyl-dopamine for the production of a medication for treatment or prophylaxis of disturbances or states due to deficiency of dopamine, preferably chosen from the group covering oxygen deficiencies (hypoxia) in anesthetized and awake mammals, breathing with atmospheric oxygen (normoxia), for the respiratory responses to hypoxia in mammals, lack of dopamine binding to the membrane system in the mammalian brain, disturbances in metabolic pathways of dopamine metabolism, states of dopamine deficiencies provoked by morbid or genetic factors as well as under condition connected to the physiological process of aging of the organism, through the systemic introduction of the compound to the mammalian organism. A method of production of 3?-O-methyl-N-oleoyl-dopamine in vitro is also disclosed.
Type:
Grant
Filed:
November 23, 2011
Date of Patent:
April 15, 2014
Assignees:
Instytut Medycyny Doswiadczalnej i Klinicznej im. M. Mossakowskiego PAN, Uniwersytet Warszawski
Inventors:
Mieczyslaw Pokorski, Dominika Zajac, Zbigniew Czarnocki, Piotr Roszkowski
Abstract: A medical application of N-oleoyl-dopamine and 3?-O-methyl-N-oleoyl-dopamine for the production of a medication for treatment or prophylaxis of disturbances or states due to deficiency of dopamine, preferably chosen from the group covering oxygen deficiencies (hypoxia) in anesthetized and awake mammals, breathing with atmospheric oxygen (normoxia), for the respiratory responses to hypoxia in mammals, lack of dopamine binding to the membrane system in the mammalian brain, disturbances in metabolic pathways of dopamine metabolism, states of dopamine deficiencies provoked by morbid or genetic factors as well as under condition connected to the physiological process of aging of the organism, through the systemic introduction of the compound to the mammalian organism. A method of production of 3?-O-methyl-N-oleoyl-dopamine in vitro is also disclosed.
Type:
Application
Filed:
November 23, 2011
Publication date:
May 23, 2013
Applicants:
Uniwersytet Warszawski, Wydzial Chemii, Instytut Medycyny Doswiadczalnej i Klinicznej im. M. Mossakowskiego PAN
Inventors:
Mieczyslaw Pokorski, Dominika Zajac, Zbigniew Czarnocki, Piotr Roszkowski