Abstract: A stereotactic head frame localizer having a plurality of fiducial rods disposed in a plurality of sides is disclosed. The stereotactic head frame localizer includes five connected sides with each side including a plurality of the fiducial rods. One of the sides may be removably attached to the stereotactic head frame localizer. The fiducial rods include a material or may be formed from a material that, in cooperation with a selected imaging modality (i.e. CT, MRI, or PET), will appear on the resulting image scan as image points. The fiducial rods may be disposed in an orientation that is horizontal, vertical, or diagonal to an axis of a body of a patient. The stereotactic head frame localizer may be used in cooperation with a head ring attached to a patient for determining the location of a target in an x, y, and z coordinate system.