Patents Assigned to Integral Molecular, Inc.
  • Antibodies directed to claudin 6, including bispecific formats thereof
    Patent number: 12049502
    Abstract: The disclosure is directed to an antibody specific for claudin 6 and CD3 and method of preparing and using the same. The present disclosure describes the isolation and characterization of antibodies, antibody fragments, and antibody variants specific for claudin 6 and CD3.
    Type: Grant
    Filed: November 29, 2023
    Date of Patent: July 30, 2024
    Assignee: Integral Molecular, Inc.
    Inventors: Joseph Rucker, Kyle Doolan
  • Glucose transporter 4 antibodies, methods of making the same, and uses thereof
    Patent number: 11834497
    Abstract: Antibodies and compositions against GLUT4 and uses thereof are provided herein.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: December 5, 2023
    Assignee: INTEGRAL MOLECULAR, INC.
    Inventors: David F. Tucker, Kimberly-Anne Mattia, Christine R. Fisher, Benjamin J. Doranz, Joseph B. Rucker
  • Antibodies comprising a common light chain and uses thereof
    Patent number: 11254736
    Abstract: Peptides and uses thereof, such as a common light chain in an antibody, are provided.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: February 22, 2022
    Assignee: INTEGRAL MOLECULAR, INC.
    Inventors: Thomas Charpentier, Ross Chambers, Lewis J. Stafford, Trevor Barnes, Jonathan T. Sullivan
  • Claudin 6 antibodies and uses thereof
    Patent number: 11248046
    Abstract: Antibodies and compositions against Claudin 6 and uses thereof are provided.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: February 15, 2022
    Assignee: Integral Molecular, Inc.
    Inventors: Ross Chambers, Joseph Rucker, Thomas Charpentier, Lewis J. Stafford, Brad Screnci, Trevor Barnes, Benjamin Doranz
  • Modified ebolavirus glycoproteins comprising mutations in the head and base domains that increase antibody cross-reactivity
    Patent number: 11135280
    Abstract: Provided herein are methods of incorporating substitutions of specified residues into a filovirus GP in order to increase immunogenicity and/or broaden the cross-reactivity of the protective immune response against other filovirus members. Also provided herein are mutant filovirus GPs comprising such substitutions.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: October 5, 2021
    Assignees: INTEGRATED BIOTHERAPEUTICS, INC., INTEGRAL MOLECULAR, INC.
    Inventors: Mohammad Javad Aman, Katie A. Howell, Edgar Davidson, Benjamin J. Doranz
  • Antibodies against chikungunya virus and uses thereof
    Patent number: 9902765
    Abstract: Embodiments disclosed herein provide for antibodies, including neutralizing antibodies, against Chikungunya virus, uses thereof, and methods of identifying antibodies, including neutralizing antibodies, against Chikungunya virus. In some embodiments, antibodies that binds to a CHIKV antigen, wherein the antigen is the CHIKV E1, E2, E3 protein, or any heterocomplex thereof are provided. In some embodiments, the antibody is an isolated antibody, a neutralizing antibody, a recombinant antibody, or any combination thereof. In some embodiments, the antibodies described herein bind to an epitope of E2 Domain A, E2 Domain B, or E1 Domain II of the CHIKV antigen. In some embodiments, the antigen is E2 protein.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: February 27, 2018
    Assignees: INTEGRAL MOLECULAR, INC., BLOOD SYSTEMS RESEARCH INSTITUTE
    Inventors: Benjamin Doranz, Kimberly-Anne Mattia, Kristen Kahle, Graham Simmons, Rachel Hua-Ning Fong, Soma Banik Banerjee
  • Lipoparticles comprising proteins, methods of making, and using the same
    Patent number: 9213027
    Abstract: The present invention relates to lipoparticles. The invention also relates to producing lipoparticles. The invention further relates to lipoparticles comprising a viral structural protein. The invention further relates to a lipoparticle comprising a membrane protein, and the lipoparticle can be attached to a sensor surface. The invention further relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: December 15, 2015
    Assignee: Integral Molecular, Inc.
    Inventors: Benjamin J. Doranz, Sharon Willis
  • Lipoparticles Comprising Proteins, Methods Of Making, And Using The Same
    Publication number: 20140135230
    Abstract: The present invention relates to lipoparticles. The invention also relates to producing lipoparticles. The invention further relates to lipoparticles comprising a viral structural protein. The invention further relates to a lipoparticle comprising a membrane protein, and the lipoparticle can be attached to a sensor surface. The invention further relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.
    Type: Application
    Filed: November 1, 2013
    Publication date: May 15, 2014
    Applicant: Integral Molecular, Inc.
    Inventors: Benjamin J. Doranz, Sharon Willis
  • Flavivirus reporter virus and methods of making and using the same
    Patent number: 8691961
    Abstract: The present invention relates to the production and uses of flavivirus replicons and flavivirus particles and reporter virus particles. The present invention relates to the production and uses of chimeric and codon-optimized flavivirus virus replicons and flavivirus virus particles and reporter virus particles.
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: April 8, 2014
    Assignee: Integral Molecular, Inc.
    Inventors: Bridget Puffer, Kimberly-Anne Mattia
  • Lipoparticles comprising proteins, methods of making, and using the same
    Patent number: 8574590
    Abstract: The present invention relates to lipoparticles. The invention also relates to producing lipoparticles. The invention further relates to lipoparticles comprising a viral structural protein. The invention further relates to a lipoparticle comprising a membrane protein, and the lipoparticle can be attached to a sensor surface. The invention further relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.
    Type: Grant
    Filed: July 28, 2004
    Date of Patent: November 5, 2013
    Assignee: Integral Molecular, Inc.
    Inventors: Benjamin J. Doranz, Sharon Willis, Eric Ross, Tiffani Anne Greene
  • LIPOPARTICLES COMPRISING ION CHANNELS, METHODS OF MAKING AND USING THE SAME
    Publication number: 20130244222
    Abstract: The present invention relates to the use of lipoparticles, virus-like particles, and viruses. The present invention also relates to testing ion channel function and modulators of ion channels.
    Type: Application
    Filed: January 15, 2013
    Publication date: September 19, 2013
    Applicant: Integral Molecular, Inc.
    Inventor: Benjamin J. Doranz
  • Lipoparticles comprising ion channels, methods of making and using the same
    Patent number: 8377691
    Abstract: The present invention relates to the use of lipoparticles, virus-like particles, and viruses. The present invention also relates to testing ion channel function and modulators of ion channels.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: February 19, 2013
    Assignee: Integral Molecular, Inc.
    Inventor: Benjamin J. Doranz
  • Reverse Transfection Of Cell Arrays For Structural And Functional Analyses Of Proteins
    Publication number: 20110077163
    Abstract: The present invention relates to articles and methods for determining the function of genes, gene products, and nucleic acid products. The present invention also relates to identifying ligands and binding partners or proteins and nucleic acid products. The present invention also relates to methods and compositions related to reverse-transfection.
    Type: Application
    Filed: September 28, 2010
    Publication date: March 31, 2011
    Applicant: INTEGRAL MOLECULAR, INC.
    Inventor: Benjamin Doranz
  • Dengue Reporter Virus and Methods of Making and Using the Same
    Publication number: 20080318208
    Abstract: The present invention relates to the production and uses of Dengue virus replicons and Dengue reporter virus particles. The present invention relates to methods of identifying inhibitors of Dengue virus infection, inhibitors of Dengue virus replication, and inhibitors of Dengue virus assembly.
    Type: Application
    Filed: February 12, 2007
    Publication date: December 25, 2008
    Applicant: Integral Molecular, Inc.
    Inventors: Bridget Puffer, Benjamin J. Doranz
  • Lipoparticles comprising ion channels, methods of making and using the same
    Publication number: 20070225227
    Abstract: The present invention relates to the use of lipoparticles, virus-like particles, and viruses. The present invention also relates to testing ion channel function and modulators of ion channels.
    Type: Application
    Filed: January 25, 2007
    Publication date: September 27, 2007
    Applicant: Integral Molecular, Inc.
    Inventor: Benjamin Doranz