Patents Assigned to INTEGRATED DIAGNOSTICS, INC.
  • Patent number: 9594085
    Abstract: Methods are provided for determining the expression level of target proteins in a subject. A plurality of respective peptide transitions are generated from a plurality of proteins obtained from a biological sample from the subject, wherein the plurality of proteins comprises both target and normalizing proteins. A mass spectroscopy (MS) signal intensity is measured from the plurality of respective peptide transitions and a plurality of corresponding stable isotope-labeled internal standard (SIS) peptide transitions. For each of the plurality of proteins, a response ratio is calculated between the MS signal intensity of the respective peptide transition and the corresponding SIS peptide transition. The response ratio for each target protein is normalized by a sample-dependent normalization factor calculated from the response ratio for each normalizing protein, wherein the normalized response ratios provide a determination of the expression level of the target proteins.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: March 14, 2017
    Assignee: INTEGRATED DIAGNOSTICS, INC.
    Inventors: Xiao-Jun Li, Stephen W. Hunsucker, Clive Hayward, Paul Edward Kearney, Lik Wee Lee
  • Publication number: 20130230877
    Abstract: Methods are provided for identifying biomarker proteins that exhibit differential expression in subjects with a first lung condition versus healthy subjects or subjects with a second lung condition. Also provided are compositions comprising these biomarker proteins and methods of using these biomarker proteins or panels thereof to diagnose, classify, and monitor various lung conditions. The methods and compositions provided herein may be used to diagnose or classify a subject as having lung cancer or a non-cancerous condition, and to distinguish between different types of cancer (e.g.
    Type: Application
    Filed: February 25, 2013
    Publication date: September 5, 2013
    Applicant: INTEGRATED DIAGNOSTICS, INC.
    Inventors: Paul Edward Kearney, Kenneth Charles Fang, Xiao-Jun Li, Clive Hayward
  • Publication number: 20130217057
    Abstract: Methods are provided for identifying biomarker proteins that exhibit differential expression in subjects with a first lung condition versus healthy subjects or subjects with a second lung condition. Also provided are compositions comprising these biomarker proteins and methods of using these biomarker proteins or panels thereof to diagnose, classify, and monitor various lung conditions. The methods and compositions provided herein may be used to diagnose or classify a subject as having lung cancer or a non-cancerous condition, and to distinguish between different types of cancer (e.g.
    Type: Application
    Filed: December 21, 2012
    Publication date: August 22, 2013
    Applicant: INTEGRATED DIAGNOSTICS, INC.
    Inventor: Integrated Diagnostics, Inc.
  • Publication number: 20130203096
    Abstract: Provided herein are methods for developing selected reaction monitoring mass spectrometry (LC-SRM-MS) assays.
    Type: Application
    Filed: December 21, 2012
    Publication date: August 8, 2013
    Applicant: INTEGRATED DIAGNOSTICS, INC.
    Inventor: Integrated Diagnostics, Inc.
  • Publication number: 20100190656
    Abstract: The present invention relates to breast cancer biomarkers useful for the detection, diagnosis and therapeutic treatment of breast cancer.
    Type: Application
    Filed: August 7, 2009
    Publication date: July 29, 2010
    Applicant: INTEGRATED DIAGNOSTICS, INC.
    Inventors: Xiaojun Li, Patricia Beckmann, Heinrich Dreismann