Patents Assigned to Integrated Genetics, Inc.
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Patent number: 4954437Abstract: A rodent epithelioid cell transformed with a recombinant DNA vector including a DNA sequence encoding human erythropoietin, the transformed cell being capable of producing N-linked and O-linked glycosylated human erythropoietin.Type: GrantFiled: September 15, 1986Date of Patent: September 4, 1990Assignee: Integrated Genetics, Inc.Inventors: Anton K. Beck, Raymond M. Withy, James R. Zabrecky, Nicholas C. Masiello
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Patent number: 4923805Abstract: Biologically active heterodimeric human FSH composed of an alpha subunit and a beta subunit, each subunit being synthesized by a cell having an expression vector containing heterologous DNA encoding the subunit.Type: GrantFiled: January 30, 1985Date of Patent: May 8, 1990Assignee: Integrated Genetics, Inc.Inventors: Vemuri B. Reddy, Nancy Hsiung, Anton K. Beck, Edward G. Berstine
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Patent number: 4908318Abstract: A method of extracting nucleic acids from a crude buffy coat fraction in an aqueous medium includes the steps of treating the buffy coat fraction to break open the white blood cells to release the proteins and the nucleic acids in the cells into the aqueous medium; solubilizing the proteins and the nucleic acids in the aqueous medium; and precipitating the nucleic acids under conditions under which the proteins remain in solution.Type: GrantFiled: September 4, 1987Date of Patent: March 13, 1990Assignee: Integrated Genetics, Inc.Inventor: Terry Lerner
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Patent number: 4840896Abstract: Biologically active heteropolymeric protein composed of a plurality of subunits, each subunit being synthesized by a cell having an expression vector heterologous DNA encoding the subunit.Type: GrantFiled: November 2, 1983Date of Patent: June 20, 1989Assignee: Integrated Genetics, Inc.Inventors: Vermuri B. Reddy, Nancy Hsiung, Anton K. Beck, Edward G. Bernstine
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Patent number: 4785086Abstract: A DNA probe and method for detecting Campylobacter jejuni, which consists essentially of a DNA sequence that is:(a) derived from a chromosomal sequence of a bacterium of the species C. jejuni or C. coli but is less than the entire chromosomal sequence of that bacterium;(b) capable of hybridizing to DNA of at least 80% of bacteria that are in the species C. jejuni and/or C. coli; and(c) not capable of hybridizing to DNA of bacteria that are not in the genus Campylobacter. The method features detecting C. jejuni in a sample by providing at least one probe capable of selectively binding to C. jejuni but not bacteria that do not belong to the genus Campylobacter, contacting that DNA probe with bacteria in the sample under conditions that allow the probe to hybridize to C. jejuni in the sample thus forming hybrid DNA complexes, and detecting the hybrid complexes as an indication of C. jejuni in the sample.Type: GrantFiled: January 17, 1985Date of Patent: November 15, 1988Assignee: Integrated Genetics, Inc.Inventors: Ayoub Rashtchian, Renee Fitts
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Patent number: 4717670Abstract: A cDNA sequence encoding porcine beta FSH.Type: GrantFiled: October 20, 1986Date of Patent: January 5, 1988Assignee: Integrated Genetics, Inc.Inventor: Anton K. Beck
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Patent number: 4696898Abstract: Recombinant DNA vector including (1) a promoter for a eukaryotic metalliothionein gene ligated to a gene sequence encoding hepatitis B surface antigen, and (2) at least the 69% transforming region of the bovine papilloma genome, expression of the hepatitis B surface antigen encoding gene sequence being under the control of the metallothionein promoter.Type: GrantFiled: January 16, 1984Date of Patent: September 29, 1987Assignee: Integrated Genetics, Inc.Inventors: Renee A. Fitts, Nancy Hsiung, Dean H. Hamer
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Patent number: 4689295Abstract: Method of detecting the presence of Salmonella in a food sample including providing at least one DNA probe which is capable of selectively hybridizing to Salmonella DNA to form detectable complexes, contacting the DNA probes with the bacteria in the food sample under conditions which allow the probe to hybridize to Salmonella DNA present in the food sample to form hybrid DNA complexes, and detecting the hybrid DNA complexes as an indication of the presence of Salmonella in the food sample.Type: GrantFiled: September 2, 1983Date of Patent: August 25, 1987Assignee: Integrated Genetics, Inc.Inventors: Robert L. Taber, Renee A. Fitts
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Patent number: 4626501Abstract: Polymeric, single-stranded DNA molecule which is labeled with a plurality of labels, the labels being bonded, via linking groups, to adenine and cytosine bases of the DNA molecule in substantially equal numbers, the labels being bonded to essentially none of the guanine or thymine bases of the DNA molecule, the DNA molecule being adapted for use as a probe in a nucleic acid hybridization assay.Type: GrantFiled: September 2, 1983Date of Patent: December 2, 1986Assignee: Integrated Genetics, Inc.Inventor: Greg M. Landes
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Patent number: 4588682Abstract: Method of binding nucleic acid to a nucleic acid-binding support comprising depositing the nucleic acid onto the support and then contacting the nucleic acid and the support with a liquid binding solution which is compatible with the support and which contains an organic solvent which is capable of binding the DNA to the support, for a period of time sufficient to effect the binding.Type: GrantFiled: December 13, 1982Date of Patent: May 13, 1986Assignee: Integrated Genetics, Inc.Inventors: Suzanne Groet, Jonathan Ostman, Robert Wydro