Patents Assigned to INTEGRATED MICRO-CHROMATOGRAPHY SYSTEMS, LLC
  • Mutant ?-glucuronidase enzymes with enhanced enzymatic activity
    Patent number: 9920306
    Abstract: Mutated ?-glucuronidase enzymes with enhanced enzymatic activity and thermostability as compared to wild type enzyme are provided. The enzymes of the invention advantageously allow for accurate analysis of bodily samples for the presence of drugs in 30 minutes or less, as compared to the several hours needed using prior enzyme preparations. Methods of using the mutated enzymes for hydrolysis of glucuronide substrates, including opiates and benzodiazepines, are also provided.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: March 20, 2018
    Assignee: INTEGRATED MICRO-CHROMATOGRAPHY SYSTEMS, LLC
    Inventor: Lim Andrew Lee