Patents Assigned to Integrated Nano-Technologies, LLC
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Patent number: 11236382Abstract: A method for preparing a sample by utilizing a shearing force in the presence of a size stabilizer to break apart the sample to obtain nucleic acid molecules in a usable size range. Once nucleic acid molecules are obtained, magnetic nanoparticles are used to concentrate and clean the nucleic acid molecules for further testing.Type: GrantFiled: June 28, 2019Date of Patent: February 1, 2022Assignee: Integrated Nano-Technologies, LLCInventors: Dennis M. Connolly, Tara Holz, Vera Tannous, Christopher Kilcoin, Konstantin Aptekarev, David B. Bailey, Richard S. Murante, Nathaniel E. Wescott
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Patent number: 10378045Abstract: A disposable cartridge for preparing a nucleic acid sample including a stationary cartridge body and a cylindrical rotor rotationally mounted to the cartridge body. The cartridge body includes: (i) a cylindrical surface defining a fixed port and (ii) a syringe barrel defining a bore in fluid communication with the fixed port. When the disposable cartridge is disposed in combination with an assay system, syringe barrel is configured to receive a moveable plunger, i.e., to stroke the plunger into and out of the barrel. The rotor is seated within a cavity of the cartridge body such that a mating surface thereof slideably engages a cylindrical surface of the cavity. The rotor comprises a plurality of chambers fluidly connecting to a plurality of ports along the mating surface at different radial positions such that at least one of the chambers is fluidly connected to one of the ports by a connecting channel.Type: GrantFiled: May 4, 2017Date of Patent: August 13, 2019Assignee: Integrated Nano-Technologies, LLCInventors: Dennis M. Connolly, Tara Holz, Vera Tannous, Christopher Kilcoin, Konstantin Aptekarev, David B. Bailey, Richard S. Murante, Nathaniel E. Wescott
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Publication number: 20170292151Abstract: A disposable cartridge for preparing a nucleic acid sample including a stationary cartridge body and a cylindrical rotor rotationally mounted to the cartridge body. The cartridge body includes: (i) a cylindrical surface defining a fixed port and (ii) a syringe barrel defining a bore in fluid communication with the fixed port. When the disposable cartridge is disposed in combination with an assay system, syringe barrel is configured to receive a moveable plunger, i.e., to stroke the plunger into and out of the barrel. The rotor is seated within a cavity of the cartridge body such that a mating surface thereof slideably engages a cylindrical surface of the cavity. The rotor comprises a plurality of chambers fluidly connecting to a plurality of ports along the mating surface at different radial positions such that at least one of the chambers is fluidly connected to one of the ports by a connecting channel.Type: ApplicationFiled: May 4, 2017Publication date: October 12, 2017Applicant: Integrated Nano-Technologies, LLCInventors: Dennis M. Connolly, Tara Holz, Vera Tannous, Christopher Kilcoin, Konstantin Aptekarev, David B. Bailey, Richard S. Murante, Nathaniel E. Wescott
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Patent number: 9644200Abstract: A method for preparing a sample by utilizing a shearing force in the presence of a size stabilizer to break apart the sample to obtain nucleic acid molecules in a usable size range. Once nucleic acid molecules are obtained, magnetic nanoparticles are used to concentrate and clean the nucleic acid molecules for further testing.Type: GrantFiled: May 18, 2016Date of Patent: May 9, 2017Assignee: Integrated Nano-Technologies, LLCInventors: Dennis M. Connolly, Tara Holz, Vera Tannous, Christopher Kilcoin, Konstantin Aptekarev, David B. Bailey, Richard S. Murante, Nathaniel E. Wescott
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Publication number: 20160326514Abstract: A method for preparing a sample by utilizing a shearing force in the presence of a size stabilizer to break apart the sample to obtain nucleic acid molecules in a usable size range. Once nucleic acid molecules are obtained, magnetic nanoparticles are used to concentrate and clean the nucleic acid molecules for further testing.Type: ApplicationFiled: May 18, 2016Publication date: November 10, 2016Applicant: Integrated Nano-Technologies, LLCInventors: Dennis M. Connolly, Tara Holz, Vera Tannous, Christopher Kilcoin, Konstantin Aptekarev, David B. Bailey, Richard S. Murante, Nathaniel E. Wescott
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Patent number: 9347086Abstract: A method for preparing a sample by utilizing a shearing force in the presence of a size stabilizer to break apart the sample to obtain nucleic acid molecules in a usable size range. Once nucleic acid molecules are obtained, magnetic nanoparticles are used to concentrate and clean the nucleic acid molecules for further testing.Type: GrantFiled: October 17, 2013Date of Patent: May 24, 2016Assignee: Integrated Nano-Technologies, LLCInventors: Dennis M. Connolly, Tara Holz, Vera Tannous, Christopher Kilcoin, Konstantin Aptekarev, David B. Bailey, Richard S. Murante, Nate Wescott
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Patent number: 8716006Abstract: A fluid delivery system having a rotating reservoir insert and a cartridge body. The rotating reservoir insert having a plurality of reservoirs in communication with ports on the external surface of the insert. The ports are positioned such that upon rotation the port is in-line with a fluid extracting device, such as a syringe, capable of extracting fluid from the reservoir.Type: GrantFiled: April 5, 2010Date of Patent: May 6, 2014Assignee: Integrated Nano-Technologies, LLCInventors: Christopher Kilcoin, Konstantin Aptekarev, Richard S. Murante, Dennis M. Connolly
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Publication number: 20140099646Abstract: A method for preparing a sample by utilizing a shearing force in the presence of a size stabilizer to break apart the sample to obtain nucleic acid molecules in a usable size range. Once nucleic acid molecules are obtained, magnetic nanoparticles are used to concentrate and clean the nucleic acid molecules for further testing.Type: ApplicationFiled: October 17, 2013Publication date: April 10, 2014Applicant: Integrated Nano-Technologies, LLCInventors: Dennis M. Connolly, Tara Holz, Vera Tannous, Christopher Kilcoin, Konstantin Aptekarev, David B. Bailey, Richard S. Murante, Nate Wescott
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Patent number: 7879534Abstract: The present invention relates to a method of manufacturing a detection device which involves providing a substrate having a layer of electrically conductive material and a first layer of photosensitive material. Next, the substrate is subjected to a first level photolithography treatment to produce an electrical conductor containing conductive fingers with spaces between them. Finally, biological probes are attached to the conductive fingers under conditions effective to form a gap between the biological probes on the spaced apart conductive fingers, whereby a target molecule, if present in a sample, can bind to a pair of the biological probes on the spaced apart conductive fingers to bridge the gap between the biological probes, allowing detection of the target molecule.Type: GrantFiled: November 19, 2002Date of Patent: February 1, 2011Assignee: Integrated Nano-Technologies LLCInventors: Hong-An Pham, Dennis M. Connolly
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Patent number: 7645574Abstract: The present invention relates to methods of metallizing nucleic acid molecules and to methods of attaching nucleic acid molecules to conductive surfaces. Methods of detecting target nucleic acid molecules based on these techniques are also disclosed.Type: GrantFiled: January 23, 2004Date of Patent: January 12, 2010Assignee: Integrated Nano-Technologies, LLCInventors: Charles D. DeBoer, Roberta J. Greco, John M. Noonan, Richard S. Murante
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Patent number: 6664103Abstract: The present invention provides nano-scale devices, including electronic circuits, using DNA molecules as a support structure. DNA binding proteins are used to mask regions of the DNA as a material, such as a metal is coated onto the DNA. Included in the invention are DNA based transistors, capacitors, inductors and diodes. The present invention also provides methods of making integrated circuits using DNA molecules as a support structure. Methods are also included for making DNA based transistors, capacitors, inductors and diodes.Type: GrantFiled: May 17, 2001Date of Patent: December 16, 2003Assignee: Integrated Nano-Technologies, LLCInventor: Dennis Michael Connolly
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Patent number: 6593090Abstract: The present invention provides methods and devices for detecting a target nucleic acid molecule. A set of oligonucleotide probes integrated into an electric circuit, where the oligonucleotide probes are positioned such that they can not come into contact with one another, are contacted with a sample. If the sample contains a target nucleic acid molecule, one which has sequences complimentary to both probes, the target nucleic acid molecule can bridge the gap between the probes. The resulting bridge can then carry electrical current between the two probes, indicating the presence of the target nucleic acid molecule.Type: GrantFiled: July 30, 2001Date of Patent: July 15, 2003Assignee: Integrated Nano-Technologies, LLCInventor: Dennis Michael Connolly
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Patent number: 6399303Abstract: The present invention provides methods and devices for detecting a target nucleic acid molecule. A set of oligonucleotide probes integrated into an electric circuit, where the oligonucleotide probes are positioned such that they can not come into contact with one another, are contacted with a sample. If the sample contains a target nucleic acid molecule, one which has sequences complimentary to both probes, the target nucleic acid molecule can bridge the gap between the probes. The resulting bridge can then carry electrical current between the two probes, indicating the presence of the target nucleic acid molecule.Type: GrantFiled: April 7, 2000Date of Patent: June 4, 2002Assignee: Integrated Nano-Technologies, LLCInventor: Dennis Michael Connolly
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Publication number: 20010044114Abstract: The present invention provides nano-scale devices, including electronic circuits, using DNA molecules as a support structure. DNA binding proteins are used to mask regions of the DNA as a material, such as a metal is coated onto the DNA. Included in the invention are DNA based transistors, capacitors, inductors and diodes. The present invention also provides methods of making integrated circuits using DNA molecules as a support structure. Methods are also included for making DNA based transistors, capacitors, inductors and diodes.Type: ApplicationFiled: May 17, 2001Publication date: November 22, 2001Applicant: Integrated Nano-Technologies, LLC.Inventor: Dennis Michael Connolly
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Patent number: 6248529Abstract: The present invention provides nano-scale devices, including electronic circuits, using DNA molecules as a support structure. DNA binding proteins are used to mask regions of the DNA as a material, such as a metal is coated onto the DNA. Included in the invention are DNA based transistors, capacitors, inductors and diodes. The present invention also provides methods of making integrated circuits using DNA molecules as a support structure. Methods are also included for making DNA based transistors, capacitors, inductors and diodes.Type: GrantFiled: May 20, 1999Date of Patent: June 19, 2001Assignee: Integrated Nano-Technologies, LLCInventor: Dennis Michael Connolly