Patents Assigned to Integrated Sensing Systems, Inc.
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Publication number: 20080269573Abstract: A system and surgical procedure for monitoring physiological parameters within an internal organ of a living body. The procedure entails making a first incision to expose the organ and a second incision through an external wall of the organ and into an internal cavity. A sensing unit is placed in the second incision such that a proximal end thereof remains outside the organ. The unit includes a sensing device having a sensing element for sensing the physiological parameter within the organ, and an anchor to which the sensing device is secured. The unit occludes the second incision and a distal end of the unit does not extend more than one centimeter into the cavity. The anchor is then secured to the wall of the organ, after which the first incision is closed and a readout device telemetrically communicates with the sensing device to obtain a reading of the physiological parameter.Type: ApplicationFiled: April 29, 2008Publication date: October 30, 2008Applicant: INTEGRATED SENSING SYSTEMS, INC.Inventors: Nader Najafi, Sonbol Massoud-Ansari, Catherine Hook Morgan
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Patent number: 7437912Abstract: A method and device for assessing rheological properties of a fluid, including lubricity and viscosity. The invention utilizes a tube into which the fluid is introduced, and relies on tracking the movement of the fluid through the tube either alone or with one or more particles intentionally introduced into the fluid to assess the rheological properties of the fluid. The method and device generally entail flowing the fluid and the optional suspended particle through a passage within the tube, and assessing a rheological property of the fluid within the tube by tracking the movement of the fluid and/or particle through the portion relative to the flow of the fluid through the portion.Type: GrantFiled: July 19, 2005Date of Patent: October 21, 2008Assignee: Integrated Sensing Systems, Inc.Inventors: Douglas Ray Sparks, Nader Najafi
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Publication number: 20080214978Abstract: A method of treating a bodily fluid withdrawn and then returned to a living body. The method involves withdrawing the bodily fluid from the living body and causing the bodily fluid to flow through a treatment system, altering at least the density of the bodily fluid through the action of a second fluid as the bodily fluid flows through the treatment system, sensing at least the density and flow rate of the bodily fluid before the density thereof is altered by the second fluid, sensing at least the density and flow rate of the bodily fluid after the density thereof is altered by the second fluid, sensing at least the density and flow rate of the second fluid, controlling the density and/or flow rate of the second fluid based on the sensed densities and flow rates, and returning the bodily fluid to the living body.Type: ApplicationFiled: April 21, 2008Publication date: September 4, 2008Applicant: INTEGRATED SENSING SYSTEMS, INC.Inventors: Douglas Ray Sparks, Nader Najafi
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Publication number: 20080152676Abstract: A device capable of delivering precise amounts of one or more antidotes to treat a victim exposed to biological and chemical agents (biochem agents), and also preferably sensing the presence of biochem agents. The delivery device includes a plurality of reservoirs containing antidotes, a manifold to which the reservoirs are fluidically and removably coupled, an outlet on the manifold, a device for selectively releasing at least one of the antidotes from the reservoirs into the manifold, a device for sensing flow of the at least one released antidote, and a device for stopping flow of the at least one released antidote in response to specified amounts of the at least one released antidote having passed through the flow sensing device.Type: ApplicationFiled: February 15, 2008Publication date: June 26, 2008Applicant: INTEGRATED SENSING SYSTEMS, INC.Inventors: Douglas Ray Sparks, Nader Najafi
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Publication number: 20080154535Abstract: A sensing and analysis system, method, and network that make use of a very portable and compact sensor unit and a physically separate electronic unit that serves to power and control the sensor unit, process and optionally display the output of the sensor unit, and transmit the sensor output to other locations, such as over a network. The sensor unit includes a housing, a sensing element within the housing and responsive to an input, and electronic circuitry within the housing and in communication with the sensing element to produce an electrical output based on an output signal generated by the sensing element. A communication providing device delivers instructions generated by the electronic unit to the sensor unit and delivers the electrical output from the sensor unit to the electronic unit.Type: ApplicationFiled: March 20, 2007Publication date: June 26, 2008Applicant: INTEGRATED SENSING SYSTEMS, INC.Inventors: Douglas Ray Sparks, Vincent Cruz, Nader Najafi
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Patent number: 7381628Abstract: A process for producing a tube suitable for microfluidic devices. The process uses first and second wafers, each having a substantially uniform doping level. The first wafer has a first portion into which a channel is etched partially therethrough between second and third portions of the first wafer. The first wafer is then bonded to the second wafer so that a first portion of the second wafer overlies the first portion of the first wafer and encloses the channel to define a passage. The second wafer is then thinned so that the first portion thereof defines a thinned wall of the passage. Second and third portions of the second wafer and part of the second and third portions of the first wafer are then removed, and the thinned wall defined by the second wafer is bonded to a substrate such that the passage projects over a recess in the substrate surface. The second and third portions of the first wafer are then removed to define a tube with a freestanding portion.Type: GrantFiled: February 20, 2006Date of Patent: June 3, 2008Assignee: Integrated Sensing Systems, Inc.Inventors: Douglas Ray Sparks, Nader Najafi
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Patent number: 7354429Abstract: A device and method capable of sensing the presence of biochem agents, and preferably also capable of delivering precise amounts of one or more antidotes to treat a victim exposed to the agents. The device includes a freestanding tube portion having an internal passage containing a substance selective to a chemical or biological agent so that matter accumulates within the freestanding tube portion when a fluid drawn through the tube portion contains the agent. When vibrated at resonance, the resonant frequency of the tube portion is indicative of the accumulation of matter and thereby the presence of the agent to which the substance is selective. The device then preferably delivers precise amounts of one or more appropriate antidotes to treat the victim. The device is a sufficiently small and lightweight unit to permit being carried by an individual.Type: GrantFiled: May 27, 2004Date of Patent: April 8, 2008Assignee: Integrated Sensing Systems, Inc.Inventors: Douglas Ray Sparks, Nader Najafi
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Patent number: 7351603Abstract: A process for producing a tube suitable for microfluidic devices. The process uses a uniformly-doped first material having a first portion into which a channel is etched partially through the first material between second and third portions of the first material. The first material is then bonded to a second material so that a first portion of the second material overlies the first portion of the first material and encloses the channel to define a passage. The second and third portions of the second material and part of the second and third portions of the first material are then removed, and the first portion of the second material is bonded to a substrate such that the passage projects over a recess in the substrate surface. The second and third portions of the first material are then removed to define a tube with a freestanding portion.Type: GrantFiled: August 22, 2005Date of Patent: April 1, 2008Assignee: Integrated Sensing Systems, Inc.Inventors: Douglas Ray Sparks, Nader Najafi
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Publication number: 20080077016Abstract: A system for monitoring physical properties of structures within animate and inanimate objects, including internal organs and bones of humans. The system includes sensing and readout devices. The sensing device is adapted to be implanted in a body and attached to a structure within the body, and includes an electrical circuit containing a first inductor coil formed at least in part by a conductor with portions thereof separated by gaps. The first inductor coil is adapted to be physically coupled to the structure so that changes in shape and size of the structure cause changes in shape and/or size of the first inductor coil and/or changes in the gaps, which alter the inductance of the first inductor coil when current flows through the electrical circuit. The readout device is not adapted to be implanted in the patient, and includes an inductor coil capable of electromagnetic telecommunication and/or electromagnetic powering of the sensing device.Type: ApplicationFiled: September 24, 2007Publication date: March 27, 2008Applicant: INTEGRATED SENSING SYSTEMS, INC.Inventors: Douglas Sparks, Nader Najafi
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Publication number: 20080051863Abstract: An anchor and procedure for placing a medical implant, such as for monitoring physiological parameters. The anchor includes a central body in which a medical implant can be received. Arms and members extend radially from first and second ends, respectively, of the central body. Each member defines a leg extending toward distal portions of the arms to provide a clamping action. The anchor and its implant are placed by coupling first and second guidewires to first and second portions of the anchor, placing an end of a delivery catheter in a wall where implantation is desired, inserting the anchor in the catheter with the guidewires to locate the anchor within the wall, deploying the arms of the anchor at one side of the wall followed by deployment of the members at the opposite side of the wall, and thereafter decoupling the guidewires from the anchor.Type: ApplicationFiled: November 1, 2007Publication date: February 28, 2008Applicant: Integrated Sensing Systems, Inc.Inventors: Richard Schneider, Nader Najafi, David Goetzinger
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Patent number: 7317951Abstract: An anchor and procedure for placing a medical implant, such as for monitoring physiological parameters. The anchor includes a central body in which a medical implant can be received. Arms and members extend radially from first and second ends, respectively, of the central body. Each member defines a leg extending toward distal portions of the arms to provide a clamping action. The anchor and its implant are placed by coupling first and second guidewires to first and second portions of the anchor, placing an end of a delivery catheter in a wall where implantation is desired, inserting the anchor in the catheter with the guidewires to locate the anchor within the wall, deploying the arms of the anchor at one side of the wall followed by deployment of the members at the opposite side of the wall, and thereafter decoupling the guidewires from the anchor.Type: GrantFiled: July 24, 2004Date of Patent: January 8, 2008Assignee: Integrated Sensing Systems, Inc.Inventors: Richard Lee Schneider, Nader Najafi, David J. Goetzinger
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Publication number: 20070205720Abstract: A getter device including a substrate formed of a first getter material having a composition for gettering a first gas specie, and a second getter material contacting an external surface of the substrate and having a composition for gettering a second gas specie. The substrate has internal porosity connected to openings at its external surface, and the second getter material covers at least a portion of the external surface of the substrate but is absent from at least part of the internal porosity within the substrate so that the first getter material is exposed within the internal porosity for gettering the first gas specie. According to a second aspect, a substrate is formed of a material transparent to radiation, and a film of getter material is deposited on the substrate to be sufficiently thin and/or porous so that the film is also transparent to the radiation transmitted through the substrate.Type: ApplicationFiled: November 13, 2006Publication date: September 6, 2007Applicant: INTEGRATED SENSING SYSTEMS, INC.Inventors: Douglas Sparks, Nader Najafi, Bernard Newman
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Patent number: 7263882Abstract: A fluid system installed on a vehicle and a method for assessing a property of a fluid flowing in the fluid system. The fluid system and method entail flowing at least a portion of the fluid through a passage within a freestanding portion of a micromachined tube supported above a substrate so as to define a gap therebetween, vibrating the freestanding portion of the micromachined tube at a resonant frequency thereof, sensing the movement of the freestanding portion of the micromachined tube so as to measure at least one of the vibration frequency and deflection of the freestanding portion relative to the substrate and produce therefrom at least one output corresponding to at least one of the mass flow rate, specific gravity, and density of the portion of the fluid flowing through the passage, and then using the output to compute the property of the fluid.Type: GrantFiled: May 26, 2006Date of Patent: September 4, 2007Assignee: Integrated Sensing Systems, Inc.Inventors: Douglas Ray Sparks, Nader Najafi
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Publication number: 20070179583Abstract: An anchor for a medical implant, a method of manufacturing an anchor, and a delivery system and method for delivering a medical implant, such as for monitoring physiological parameters, for example, for diagnosing and/or monitoring and/or treating cardiovascular diseases, such as CHF and CHD. The anchor includes a base member, arms, legs, features for securing the medical implant to the base member, and features for connecting the anchor to a connector. The anchor has a deployed configuration in which the arms radially project from a first end of the base member and the legs radially project from an opposite end of the base member. When deployed, the arms and legs terminate at extremities that are opposing but not aligned with each other.Type: ApplicationFiled: March 12, 2007Publication date: August 2, 2007Applicant: INTEGRATED SENSING SYSTEMS, INC.Inventors: David Goetzinger, Nader Najafi
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Publication number: 20070157739Abstract: A microfluidic device and method for assessing properties of a fluid. The device includes a base supported by a substrate and a tube extending from the base and spaced apart from the substrate surface. The tube has an internal passage, first and second portions adjacent the base and defining, respectively, an inlet and outlet of the passage, and a distal portion. A drive electrode is located on the substrate surface adjacent the distal portion of the tube. Sensing electrodes are located on the substrate surface adjacent the first and second portions of the tube, and are adapted for sensing deflections of the first and second portions when vibrated with the drive electrode and from which the fluid property is determined. A pair of electrodes is located on the substrate surface between the drive and sensing electrodes, and are operated to enhance the performance of the microfluidic device, such as by supplementing the drive or sensing electrodes.Type: ApplicationFiled: January 8, 2007Publication date: July 12, 2007Applicant: INTEGRATED SENSING SYSTEMS, INC.Inventors: Douglas Ray Sparks, Rick Smith, Nader Najafi
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Publication number: 20070151335Abstract: A microfluidic device a micromachined freestanding member adapted to sense one or more properties of a fluid flowing through the freestanding member. The freestanding member is supported by a substrate and spaced apart and separated from the substrate to enable the freestanding member to move relative to the substrate under the influence of a vibration-inducing element. Movement of the freestanding member relative to the substrate is then sensed by a sensing element. The freestanding member has an inlet, an outlet, an internal passage that fluidically couples the inlet and outlet, and a wall that defines and separates first and second passage portions of the internal passage that are arranged in fluidic series so that a fluid flowing through the internal passage flows through the first and second passage portions in opposite directions.Type: ApplicationFiled: January 5, 2007Publication date: July 5, 2007Applicant: INTEGRATED SENSING SYSTEMS, INC.Inventors: Douglas Sparks, Nader Najafi
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Patent number: 7228735Abstract: A micromachined fluid sensing device and a method for its fabrication. The sensing device incorporates a bypass passage, preferably an integral bypass passage within the device, that enables a volume of fluid to be delivered to the device, with a limited portion of the fluid passing through a passage within the device in which one or more properties of the fluid are sensed, such as but not limited to density, specific gravity, and chemical concentrations. The device is suitable for monitoring the fuel concentration in a fuel mixture for a fuel cell.Type: GrantFiled: November 21, 2005Date of Patent: June 12, 2007Assignee: Integrated Sensing Systems, Inc.Inventors: Douglas Ray Sparks, Nader Najafi
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Patent number: 7211048Abstract: A system for non-invasively monitoring one or more physiological parameters such as pressure and/or pressure gradients in a cardiac conduit adapted for blood bypass flow. The system includes the conduit, at least one sensing device chronically located within the conduit, and a non-implantable readout device. The sensing device includes at least one inductor coil and at least one sensor for monitoring the one or more physiological parameters for diagnosis of the condition of the conduit after the conduit is implanted in a patient. The readout device includes at least one inductor coil allowing electromagnetic telecommunication and electromagnetic wireless powering of the sensing device through the inductor coil thereof.Type: GrantFiled: October 6, 2003Date of Patent: May 1, 2007Assignee: Integrated Sensing Systems, Inc.Inventors: Nader Najafi, Collin Anderson Rich, Sonbol Massoud-Ansari
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Publication number: 20070032734Abstract: A method of monitoring physiological parameters for diagnosis and treatment of congestive heart failure in a patient. The method includes implanting at least one sensing device in a cavity of the patient's cardiovascular system, preferably so that the sensing device passes through and is anchored to a septum of the heart and, to minimize the risk of thrombogenicity, a larger portion of the sensing device is located in the right side of the heart and a smaller portion of the sensing device is located in the left side of the heart. Electromagnetic telecommunication and/or wireless powering of the sensing device is performed with an external readout device. The method can be used to perform effective monitoring, management, and tailoring of treatments for patients suffering from congestive heart failure, as well as many other diseases.Type: ApplicationFiled: July 21, 2006Publication date: February 8, 2007Applicant: INTEGRATED SENSING SYSTEMS, INC.Inventors: Nader Najafi, Collin Rich
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Publication number: 20060213552Abstract: A fluid system installed on a vehicle and a method for assessing a property of a fluid flowing in the fluid system. The fluid system and method entail flowing at least a portion of the fluid through a passage within a freestanding portion of a micromachined tube supported above a substrate so as to define a gap therebetween, vibrating the freestanding portion of the micromachined tube at a resonant frequency thereof, sensing the movement of the freestanding portion of the micromachined tube so as to measure at least one of the vibration frequency and deflection of the freestanding portion relative to the substrate and produce therefrom at least one output corresponding to at least one of the mass flow rate, specific gravity, and density of the portion of the fluid flowing through the passage, and then using the output to compute the property of the fluid.Type: ApplicationFiled: May 26, 2006Publication date: September 28, 2006Applicant: INTEGRATED SENSING SYSTEMS, INC.Inventors: Douglas Sparks, Nader Najafi