Patents Assigned to Integrated Vascular Systems, Inc.
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Patent number: 8202293Abstract: An apparatus for delivering a closure element can include a splittable carrier tube and a splitter to split the tube. The carrier tube can have an outer surface retaining a closure element in a tubular configuration and can be split into radially-expandable flaps. A closure element has can have shape-memory body having a relaxed configuration with a planar-annular body defining a lumen with tines directed inwardly from the body. The clip can be held in a retaining configuration having a substantially asymmetrically-elongated tubular shape with a trapezoidal longitudinal cross-sectional profile and a proximal end having the tines being longitudinally directed with a first tine being more distally oriented compared to a substantially opposite second tine being more proximal, and retracting to a deploying configuration having a tubular shape with a rectangular longitudinal cross-sectional profile with the first tine being even with the second tine when being delivered.Type: GrantFiled: June 20, 2008Date of Patent: June 19, 2012Assignee: Integrated Vascular Systems, Inc.Inventors: Brian A. Ellingwood, Laveille K. Voss, T. Daniel Gross, Kelly J. McCrystle
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Patent number: 8202283Abstract: The present disclosure relates to a clip manufactured according to a method which can be used to engage body tissue for the purpose of closing wounds. Such clips are generally annular in shape and have radially inwardly extending tines. The present disclosure first forms a precursor which, in one embodiment, has the tines extending radially outwardly from the annular body and then forms the clip by inverting the precursor such that the tines extend radially inwardly. In an alternate embodiment, the precursor is formed with an over-sized lateral dimension and then compressed inwardly to bring the tines closer together and to reduce the lateral dimension of the precursor. Such clips may be manufactured from a superelastic alloy such as nickel-titanium, in which case the inverted or compressed precursor must be heated and quenched to heat set the clip in its final shape.Type: GrantFiled: November 12, 2010Date of Patent: June 19, 2012Assignee: Integrated Vascular Systems, Inc.Inventors: Michael T. Carley, Richard S. Ginn
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Patent number: 8182497Abstract: A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another.Type: GrantFiled: October 4, 2010Date of Patent: May 22, 2012Assignee: Integrated Vascular Systems, Inc.Inventors: Michael T. Carley, Richard S. Ginn, Francisco Javier Sagastegui, Ronald J. Jabba, William N. Aldrich, W. Martin Belef
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Patent number: 8128644Abstract: A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.Type: GrantFiled: September 19, 2003Date of Patent: March 6, 2012Assignee: Integrated Vascular Systems, Inc.Inventors: Michael T. Carley, Richard S. Ginn, Javier Sagastegui, Ronald J. Jabba, William N. Aldrich, W. Martin Belef
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Publication number: 20110313452Abstract: A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.Type: ApplicationFiled: August 31, 2011Publication date: December 22, 2011Applicant: INTEGRATED VASCULAR SYSTEMS, INC.Inventors: Michael T. Carley, Richard S. Ginn, Javier Sagastegui, Ronald J. Jabba, William N. Aldrich, W. Martin Belef
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Publication number: 20110230897Abstract: An apparatus for delivering a closure element can include a splittable carrier tube and a splitter to split the tube. The carrier tube can have an outer surface retaining a closure element in a tubular configuration and can be split into radially-expandable flaps. A closure element can have a shape-memory body having a relaxed configuration with a planar-annular body defining a lumen with tines directed inwardly from the body. The clip can be held in a retaining configuration having a substantially asymmetrically-elongated tubular shape with a trapezoidal longitudinal cross-sectional profile and a proximal end having the tines being longitudinally directed with a first tine being more distally oriented compared to a substantially opposite second tine being more proximal, and retracting to a deploying configuration having a tubular shape with a rectangular longitudinal cross-sectional profile with the first tine being even with the second tine when being delivered.Type: ApplicationFiled: March 2, 2011Publication date: September 22, 2011Applicant: INTEGRATED VASCULAR SYSTEMS, INC.Inventors: Thomas J. Palermo, William M. Belef, Michael T. Carley, Richard S. Ginn, Anthony J. Pantages, Ronald J. Jabba, Brian A. Ellingwood, Laveille Kao Voss, Kelly J. McCrystle, T. Daniel Gross, Arkady Kokish
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Patent number: 8007512Abstract: An apparatus for delivering a clip includes an introducer sheath including an outer surface extending between its proximal and distal ends, and a hub on the proximal end that includes spacer elements spaced away from the outer surface. An annular clip includes a plurality of tines extending from its distal end and its proximal end is held away from the outer surface of the sheath by the spacer elements. A handle assembly is attached to the hub that includes an actuator member slidable between the spacer elements and the outer surface of the sheath. The actuator member includes radial protrusions for coupling with the clip, whereby distal movement of the actuator member advances the clip towards the distal end of the sheath. Optionally, a skin overlies the outer surface of the sheath and the clip that is separable from the outer surface as the clip is advanced.Type: GrantFiled: October 8, 2003Date of Patent: August 30, 2011Assignee: Integrated Vascular Systems, Inc.Inventors: Richard S. Ginn, Anthony Pantages
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Publication number: 20110166584Abstract: An apparatus for delivering a closure element into an opening formed in a blood vessel or other body lumen and methods for manufacturing and using same. The apparatus is configured to retain the closure element such that the closure element is disposed substantially within the apparatus. The apparatus also can engage, and position the closure element substantially adjacent to, the blood vessel wall adjacent to the opening. During deployment of the closure element, the apparatus expands the closure element beyond a natural cross-section of the closure element such that the closure element, when deployed, is configured to engage a significant amount of the blood vessel wall and/or tissue. Engaging the blood vessel wall and/or tissue, the closure element is further configured to return to the natural cross-section, thereby drawing the engaged blood vessel wall and/or tissue substantially closed and/or sealed, such that hemostasis within the opening is enhanced.Type: ApplicationFiled: January 10, 2011Publication date: July 7, 2011Applicant: INTEGRATED VASCULAR SYSTEMS, INC.Inventors: Thomas J. Palermo, William M. Belef, Michael T. Carley, Richard S. Ginn, Ronald J. Jabba, Anthony Pantages
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Publication number: 20110144664Abstract: An apparatus for delivering a closure element into an opening formed in a blood vessel or other body lumen and methods for manufacturing and using same. The apparatus is configured to retain the closure element such that the closure element is disposed substantially within the apparatus. The apparatus also can engage, and position the closure element substantially adjacent to, the blood vessel wall adjacent to the opening. During deployment of the closure element, the apparatus expands the closure element beyond a natural cross-section of the closure element such that the closure element, when deployed, is configured to engage a significant amount of the blood vessel wall and/or tissue. Engaging the blood vessel wall and/or tissue, the closure element is further configured to return to the natural cross-section, thereby drawing the engaged blood vessel wall and/or tissue substantially closed and/or sealed, such that hemostasis within the opening is enhanced.Type: ApplicationFiled: December 20, 2010Publication date: June 16, 2011Applicant: INTEGRATED VASCULAR SYSTEMS, INC.Inventors: Ronald Jabba, W. Martin Belef
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Publication number: 20110144668Abstract: A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another.Type: ApplicationFiled: October 4, 2010Publication date: June 16, 2011Applicant: INTEGRATED VASCULAR SYSTEMS, INC.Inventors: Michael T. Carley, Richard S. Ginn, Javier Sagastegui, Jana Sagastegui, Ronald J. Jabba, William N. Aldrich, W. Martin Belef
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Publication number: 20110106148Abstract: A closure system and methods of use are provided for use in sealing an opening in a body tissue, such as a vascular puncture site. A method of closing the opening in the body tissue can be performed with the closure system having a closure clip. The method can include positioning the closure clip in a first closure clip position adjacent to the opening in the body tissue such that a plurality of spikes of the closure clip are inserted into the tissue at a location outward from a central axis of the opening. Subsequently, the closure clip can be positioned in a second closure clip position such that the plurality of spikes are pulled inward toward the central axis of the opening so as to pull the tissue between the opening and each of the spikes together and close the opening.Type: ApplicationFiled: November 8, 2010Publication date: May 5, 2011Applicant: INTEGRATED VASCULAR SYSTEMS, INC.Inventors: Richard S. Ginn, William N. Aldrich, William Martin Belef, Steven N. Roe, Michael T. Carley, Ronald J. Jabba, Stephen M. Salmon, Anthony J. Pantages, Francisco Javier Sagastegui
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Patent number: 7931669Abstract: Apparatus and methods are provided for use in sealing a vascular puncture site. The invention comprises an integrated vascular device having a sheath with a closure component and puncture sealant. The closure component is disposed on and advanceable over the exterior of the sheath and may comprise any of a variety of apparatus suited for closing a vascular puncture. Once the closure component has been actuated to close the puncture, sealant is introduced to seal the puncture. The sheath and closure component are then removed from the patient.Type: GrantFiled: May 17, 2002Date of Patent: April 26, 2011Assignee: Integrated Vascular Systems, Inc.Inventors: Richard S. Ginn, W. Martin Belef
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Publication number: 20110071565Abstract: An apparatus for sealing a passage through tissue includes a tubular member, a plug, and a locator member. The plug is disposed on a distal end of the tubular member and includes an external thread. The locator member is inserted into a lumen of the tubular member until a distal portion is disposed beyond the plug. The distal portion includes a helically wound wire and a tether coupled to the wire that is movable for causing the wire to buckle. To seal a passage communicating with a blood vessel, the distal portion of the locator member is inserted into the passage, and the plug is threaded into the passage until the distal portion extends into the vessel. The tether is pulled to buckle the wire, and the plug is unthreaded until the buckled wire contacts a wall of the vessel, whereupon the plug is released to seal the passage.Type: ApplicationFiled: November 29, 2010Publication date: March 24, 2011Applicant: INTEGRATED VASCULAR SYSTEMS, INC.Inventor: Richard S. Ginn
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Patent number: 7905900Abstract: An apparatus for delivering a closure element into an opening formed in a blood vessel or other body lumen and methods for manufacturing and using same. The apparatus is configured to retain the closure element such that the closure element is disposed substantially within the apparatus. The apparatus also can engage, and position the closure element substantially adjacent to, the blood vessel wall adjacent to the opening. During deployment of the closure element, the apparatus expands the closure element beyond a natural cross-section of the closure element such that the closure element, when deployed, is configured to engage a significant amount of the blood vessel wall and/or tissue. Engaging the blood vessel wall and/or tissue, the closure element is further configured to return to the natural cross-section, thereby drawing the engaged blood vessel wall and/or tissue substantially closed and/or sealed, such that hemostasis within the opening is enhanced.Type: GrantFiled: January 30, 2003Date of Patent: March 15, 2011Assignee: Integrated Vascular Systems, Inc.Inventors: Thomas J. Palermo, William M. Belef, Michael T. Carley, Richard S. Ginn, Ronald J. Jabba, Anthony J. Pantages, Francisco Javier Sagastegui
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Patent number: 7901428Abstract: Apparatus and methods are provided for use in sealing a vascular puncture site. The invention includes an introducer sheath with an integrated closure component. The closure component includes a fastener and an advanceable, deformable clip having a delivery configuration in which opposing sides do not contact one another, and a deployed configuration, in which the fastener causes opposing sides of the deformable clip to close towards one another. The clip is advanced along the sheath until it pierces opposing sides of a vessel wall at a puncture site. The clip is then deformed with the fastener to draw opposing sides of the puncture together, and the sheath is withdrawn to seal the wound. The clip and fastener preferably are bioabsorbable.Type: GrantFiled: October 3, 2002Date of Patent: March 8, 2011Assignee: Integrated Vascular Systems, Inc.Inventors: Richard S. Ginn, William N. Aldrich
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Patent number: 7887555Abstract: A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.Type: GrantFiled: July 9, 2003Date of Patent: February 15, 2011Assignee: Integrated Vascular Systems, Inc.Inventors: Michael T. Carley, Richard S. Ginn, Javier Sagastegui, Ronald J. Jabba, William N. Aldrich, W. Martin Belef
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Patent number: 7879071Abstract: A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.Type: GrantFiled: May 9, 2003Date of Patent: February 1, 2011Assignee: Integrated Vascular Systems, Inc.Inventors: Michael T. Carley, Richard S. Ginn, Javier Sagastegui, Ronald J. Jabba, William N. Aldrich, W. Martin Belef
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Patent number: 7867249Abstract: An apparatus for delivering a closure element into an opening formed in a blood vessel or other body lumen and methods for manufacturing and using same. The apparatus is configured to retain the closure element such that the closure element is disposed substantially within the apparatus. The apparatus also can engage, and position the closure element substantially adjacent to, the blood vessel wall adjacent to the opening. During deployment of the closure element, the apparatus expands the closure element beyond a natural cross-section of the closure element such that the closure element, when deployed, is configured to engage a significant amount of the blood vessel wall and/or tissue. Engaging the blood vessel wall and/or tissue, the closure element is further configured to return to the natural cross-section, thereby drawing the engaged blood vessel wall and/or tissue substantially closed and/or sealed, such that hemostasis within the opening is enhanced.Type: GrantFiled: August 8, 2003Date of Patent: January 11, 2011Assignee: Integrated Vascular Systems, Inc.Inventors: Thomas J Palermo, William M Belef, Michael T Carley, Richard S Ginn, Ronald J Jabba, Anthony Pantages
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Patent number: 7857828Abstract: An apparatus for delivering a closure element into an opening formed in a blood vessel or other body lumen and methods for manufacturing and using same. The apparatus is configured to retain the closure element such that the closure element is disposed substantially within the apparatus. The apparatus also can engage, and position the closure element substantially adjacent to, the blood vessel wall adjacent to the opening. During deployment of the closure element, the apparatus expands the closure element beyond a natural cross-section of the closure element such that the closure element, when deployed, is configured to engage a significant amount of the blood vessel wall and/or tissue. Engaging the blood vessel wall and/or tissue, the closure element is further configured to return to the natural cross-section, thereby drawing the engaged blood vessel wall and/or tissue substantially closed and/or sealed, such that hemostasis within the opening is enhanced.Type: GrantFiled: February 1, 2005Date of Patent: December 28, 2010Assignee: Integrated Vascular Systems, Inc.Inventors: Ronald Jabba, W. Martin Belef
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Patent number: 7854810Abstract: The present invention relates to a method of making clips which can be used to engage body tissue for the purpose of closing wounds. Such clips are generally annular in shape and have radially inwardly extending tines. The present invention first forms a precursor which, in one embodiment, has the tines extending radially outwardly from the annular body and then forms the clip by inverting the precursor such that the tines extend radially inwardly. In an alternate embodiment, the precursor is formed with an over-sized lateral dimension and then compressed inwardly to bring the tines closer together and to reduce the lateral dimension of the precursor. It is preferred to manufacture such clips from a superelastic alloy such as nickel-titanium, in which case the inverted or compressed precursor must be heated and quenched to heat set the clip in its final shape.Type: GrantFiled: December 17, 2003Date of Patent: December 21, 2010Assignee: Integrated Vascular Systems, Inc.Inventors: Michael T. Carley, Richard S. Ginn