Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
Type:
Grant
Filed:
August 21, 2008
Date of Patent:
July 16, 2013
Assignees:
Board of Regents, The University of Texas System, Integrico Composites, Inc.
Inventors:
Chris Brough, James W. McGinity, Dave A. Miller, James DiNunzio, Robert O. Williams