Abstract: The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating lipid kinases such PB kinases, tryosine kinases and protein kinases such as mTOR. Also provided in the present invention are methods of using these compositions to modulate these kinases especially for therapeutic applications.
Type:
Grant
Filed:
March 16, 2009
Date of Patent:
January 28, 2014
Assignee:
Intellikine, Inc.
Inventors:
Yi Liu, Pingda Ren, Liansheng Li, Katrina Chan, Troy Edward Wilson
Abstract: Chemical entities of Formula I: that modulate PI3 kinase activity, pharmaceutical compositions containing the chemical entities, and methods of using these chemical entities for treating diseases and conditions associated with P13 kinase activity are described herein.
Type:
Grant
Filed:
July 15, 2009
Date of Patent:
June 5, 2012
Assignee:
Intellikine, Inc.
Inventors:
Pingda Ren, Yi Liu, Troy Edward Wilson, Liansheng Li, Katrina Chan, Christian Rommel
Abstract: The present invention provides methods and compositions for selective modulation of certain protein kinases, and especially mTor complexes. The methods and compositions are particularly useful in inhibiting mTor selectively for therapeutic applications.
Type:
Application
Filed:
July 8, 2009
Publication date:
September 15, 2011
Applicants:
The Regents of the University of California, a California corporation, Intellikine, Inc.
Inventors:
Kevan M. Shokat, David Fruman, Pingda Ren, Troy Edward Wilson, Liansheng Li, Andrew Hsieh, Morris Feldman, Beth Apsel, Yi Liu, Christian Rommel, Katrina Chan, Davide Ruggero, David Pearce, Matthew Janes