Abstract: A pharmaceutical paste composition comprising an active ingredient such as an addictive substance, a controlled release agent, and a pharmaceutically suitable aqueous or non-aqueous carrier. The composition may comprise one or more of a clay, or an oily, waxy, or fatty substance. The composition may be filled into a capsule or other dispensing device. The composition may reduce dose dumping of an active ingredient. Methods of making and using the composition are also described.
Abstract: The present invention is concerned with the use of transition coating and transition coating composition to control and or target the release of active pharmaceutical ingredients, and biological, chemical, neutraceutical, agricultural and nutritional materials and a method of preparing controlled release systems utilizing these components.
Abstract: An oral pharmaceutical composition comprises multiple populations of at least one of beads, pellets, tablets and granules provided in a capsule, the composition comprising: a first population of a pharmaceutical active comprising a pharmaceutical active substance releasable at a first rate; a population of a basic substance; and a second population of a pharmaceutical active comprising a pharmaceutical active substance releasable at a second rate. In another embodiment, the oral pharmaceutical composition comprises multiple populations of at least one of beads, pellets, tablets and granules provided in a capsule, the composition comprising: a population of a pharmaceutical active; a population of a basic substance; a population of enteric coated pharmaceutical active; and a population of enteric coated basic substance. The composition can provide multiple site specific delivery of a pharmaceutical active in a rapid, delayed and/or sustained release manner into the plasma.
Abstract: The present invention relates to a controlled release pharmaceutical formulation comprising an effective amount of an active ingredient and from about 1% to about 70% by weight of an uncrosslinked polymer, a crosslinked insoluble polymer or a mixture of uncrosslinked and crosslinked polymers.