Abstract: Single use syringe which self-destructs in one-time use, precluding reuse thereof. The single use syringe consists of a barrel and a piston slideably arranged therein, the piston comprising two parts, namely, a cylindrical hollow body 1 and, arranged therein, a plunger 5 which at its front side carries a punch 6 that faces the front wall 2 of hollow part 1. During the injection process, the front wall 2 of the cylindrical hollow body 1 is pierced by punch 6, so that any attempt to draw up the previously used single use syringe again would cause the space in the barrel to draw air through the opening formed by the punch in the front wall 2 of cylindrical hollow body 1.