Patents Assigned to Intercept Pharmaceuticals, Inc.
  • TGR5 Modulators and Methods of Use Thereof
    Publication number: 20120115832
    Abstract: The invention relates to compounds of Formula A: or a salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, liver disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
    Type: Application
    Filed: December 7, 2011
    Publication date: May 10, 2012
    Applicant: Intercept Pharmaceuticals, Inc.
    Inventor: Roberto Pellicciari
  • Steroids as Agonists for FXR
    Publication number: 20120053163
    Abstract: The invention relates to compounds of formula (I): wherein R is ethyl, propyl or allyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.
    Type: Application
    Filed: November 3, 2011
    Publication date: March 1, 2012
    Applicant: Intercept Pharmaceuticals, Inc.
    Inventor: Roberto Pellicciari
  • TGR5 modulators and methods of use thereof
    Patent number: 8114862
    Abstract: The invention relates to compounds of Formula A: or a salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, liver disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
    Type: Grant
    Filed: November 19, 2009
    Date of Patent: February 14, 2012
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventor: Roberto Pellicciari
  • Steroids as agonists for FXR
    Patent number: 8058267
    Abstract: The invention relates to compounds of formula (I): wherein R is ethyl and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: November 15, 2011
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventor: Roberto Pellicciari
  • Process for preparing 3a(?)-7a(?)-dihydroxy-6a(?)-alkyl-5?-cholanic acid
    Patent number: 7994352
    Abstract: Process for preparing 3?-7?(?)-dihydroxy-6?(?)-alkyl-5?-cholanic acid (I) in which R is a linear or branched C1-C5 alkyl and the relative intermediates 3?-hydroxy-6?-alkyl-7-keto-5?-cholanic (VIII) and 3?-hydroxy-6?-alkyl-7-keto-5?-cholanic (IX).
    Type: Grant
    Filed: May 19, 2006
    Date of Patent: August 9, 2011
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventors: Massimo Ferrari, Roberto Pellicciari
  • TGR5 Modulators And Methods Of Use Thereof
    Publication number: 20110172198
    Abstract: The invention relates to compounds of Formula A: (A) or a salt, solvate, or hydrate thereof. The compounds of formula A are TGR5 modulators useful for the treatment of disease.
    Type: Application
    Filed: July 30, 2009
    Publication date: July 14, 2011
    Applicant: Intercept Pharmaceuticals, Inc.
    Inventor: Roberto Pellicciari
  • Bile acid derivatives as FXR ligands for the prevention or treatment of FXR-mediated diseases or conditions
    Patent number: 7932244
    Abstract: The present invention relates to compounds of formula (I): wherein R is hydrogen or alpha-hydroxy, the hydroxyl group in position 7 is in the alpha or beta position; and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: April 26, 2011
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventors: Roberto Pellicciari, Stefano Fiorucci, Mark Pruzanski
  • Bile acid derivatives as FXR ligands for the prevention or treatment of FXR-mediated diseases or conditions
    Patent number: 7858608
    Abstract: The present invention relates to compounds of formula (I) wherein: R1 is hydrogen or an alkyl group; R2 is hydrogen or a halogen, nitro, alkyloxy, amino or carboxy group; Y is CH2, oxygen or sulfur; n is an integer from 1 to 4, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof for the treatment of FXR-mediated diseases or conditions.
    Type: Grant
    Filed: May 4, 2009
    Date of Patent: December 28, 2010
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventors: Roberto Pellicciari, Stefano Fiorucci, Mark Pruzanski
  • Steroid agonist for FXR
    Patent number: 7812011
    Abstract: The invention relates to a FXR agonist of formula (I) and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: October 12, 2010
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventor: Roberto Pellicciari
  • Steroids as agonists for FXR
    Patent number: 7786102
    Abstract: The invention relates to compounds of formula (I): wherein R is ethyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.
    Type: Grant
    Filed: November 21, 2006
    Date of Patent: August 31, 2010
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventor: Roberto Pellicciari
  • TGR5 MODULATORS AND METHODS OF USE THEROF
    Publication number: 20100152151
    Abstract: The invention relates to compounds of Formula A: or a salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, liver disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
    Type: Application
    Filed: November 19, 2009
    Publication date: June 17, 2010
    Applicant: Intercept Pharmaceuticals, Inc.
    Inventor: Roberto Pellicciari
  • BILE ACID DERIVATIVES AS FXR LIGANDS FOR THE PREVENTION OR TREATMENT OF FXR-MEDIATED DISEASES OR CONDITIONS
    Publication number: 20100063018
    Abstract: The present invention relates to compounds of formula (I) wherein: R1 is hydrogen or an alkyl group; R2 is hydrogen or a halogen, nitro, alkyloxy, amino or carboxy group; Y is CH2, oxygen or sulfur; n is an integer from 1 to 4, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof for the treatment of FXR-mediated diseases or conditions.
    Type: Application
    Filed: May 4, 2009
    Publication date: March 11, 2010
    Applicant: Intercept Pharmaceuticals, Inc.
    Inventors: Roberto Pellicciari, Stefano Fiorucci, Mark Pruzanski
  • STEROIDS AS AGONISTS FOR FXR
    Publication number: 20100022498
    Abstract: The invention relates to compounds of formula (I): wherein R is ethyl and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.
    Type: Application
    Filed: August 25, 2009
    Publication date: January 28, 2010
    Applicant: Intercept Pharmaceuticals, Inc.
    Inventor: Roberto Pellicciari
  • Bile acid derivatives as FXR ligands for the prevention or treatment of FXR-mediated diseases or conditions
    Publication number: 20080182832
    Abstract: The present invention relates to compounds of formula (I): wherein R is hydrogen or alpha-hydroxy, the hydroxyl group in position 7 is in the alpha or beta position; and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof.
    Type: Application
    Filed: June 27, 2007
    Publication date: July 31, 2008
    Applicant: Intercept Pharmaceuticals, Inc.
    Inventors: Roberto Pellicciari, Stefano Fiorucci, Mark Pruzanski
  • Novel Steroid Agonist For Fxr
    Publication number: 20080039435
    Abstract: The invention relates to a FXR agonist of formula (I) and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof.
    Type: Application
    Filed: February 28, 2005
    Publication date: February 14, 2008
    Applicant: Intercept Pharmaceuticals, Inc.
    Inventor: Roberto Pellicciari
  • Steroids as agonists for FXR
    Publication number: 20070142340
    Abstract: The invention relates to compounds of formula (I): wherein R is ethyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.
    Type: Application
    Filed: November 21, 2006
    Publication date: June 21, 2007
    Applicant: Intercept Pharmaceuticals, Inc.
    Inventor: Roberto Pellicciari
  • Method of reducing drug-induced adverse side effects in a patient
    Publication number: 20060252670
    Abstract: The invention relates to the discovery that farnesoid X receptor (FXR) agonists can be used in combination with peroxisome proliferation activated receptor gamma (PPAR?) agonists to reduce drug-induced adverse side effects in patients suffering from conditions such as insulin resistance, Type II diabetes, metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and heart disease. Particularly, the present invention encompasses methods for treating patients suffering from drug-induced adverse side effects with selective PPAR?, dual PPAR?/? and pan PPAR?/?/? agonists in combination with FXR agonists.
    Type: Application
    Filed: October 13, 2005
    Publication date: November 9, 2006
    Applicant: Intercept Pharmaceuticals Inc.
    Inventors: Stefano Fiorucci, Roberto Pellicciari, Mark Pruzanski
  • Treatment of fibrosis using FXR ligands
    Publication number: 20060069070
    Abstract: The present invention relates to a method for inhibiting fibrosis that occurs in an organ where the farnesoid X receptor (FXR) is expressed. This method involves the step of administering a high potency, activating ligand of FXR in an effective amount to a patient who is not suffering from a cholestatic condition. The invention also provides pharmaceutical compositions containing an effective amount of an FXR ligand and kits for dispensing the pharmaceutical compositions.
    Type: Application
    Filed: March 14, 2005
    Publication date: March 30, 2006
    Applicant: Intercept Pharmaceuticals, Inc.
    Inventors: Stefano Fiorucci, Roberto Pellicciari, Mark Pruzanski