Patents Assigned to Interface Biologics Inc.
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Patent number: 11766511Abstract: The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.Type: GrantFiled: February 5, 2021Date of Patent: September 26, 2023Assignee: Interface Biologics, Inc.Inventors: Sanjoy Mullick, Weilun Chang, Hanje Chen, Mark A. Steedman, Roseita Esfand
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Patent number: 11318232Abstract: The invention relates to balloon coatings and their use in delivering drugs via a drug-eluting balloon. The delivery can be, e.g., to a vessel wall.Type: GrantFiled: February 21, 2020Date of Patent: May 3, 2022Assignee: Interface Biologics, Inc.Inventors: Bernadette Ilagan, Yulin Wang, Georgios Rizis, Bingqing Yang, Wendy Alison Naimark
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Patent number: 10195311Abstract: The invention relates to oligofluorinated coatings and their use in drag delivery. The oligofluorinated coatings are compositions comprising formula (XVII). These coatings are used in a method of delivering a biologically active agent to a tissue surface in a mammalian tissue. This method occurs by contacting the surface with the coating including an oligofluorinated oligomer and a biologically active agent wherein the coating resides on the tissue surface and release the biologically active agent to the tissue surface.Type: GrantFiled: November 4, 2014Date of Patent: February 5, 2019Assignee: Interface Biologics, Inc.Inventors: Roseita Esfand, J. Paul Santerre, Sylvia Tjahyadi, Bernadette Ilagan
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Patent number: 10039864Abstract: The invention features oligofluorinated cross-linked polymers and their use in the manufacture of articles and coating surfaces.Type: GrantFiled: December 8, 2016Date of Patent: August 7, 2018Assignee: Interface Biologics, Inc.Inventors: Roseita Esfand, J. Paul Santerre, Mark J. Ernsting, H. Hung Pham, Vivian Z. Wang, Meilin Yang
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Patent number: 9884146Abstract: The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.Type: GrantFiled: September 19, 2014Date of Patent: February 6, 2018Assignee: Interface Biologics Inc.Inventors: Sanjoy Mullick, Weilun Chang, Hanje Chen, Mark A. Steedman, Roseita Esfand
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Patent number: 9764884Abstract: The invention features a packaging material including a film having a barrier layer formed from an admixture containing a base polymer and a surface-modifying macromolecule. The invention also features containers made from the packaging materials and methods of storing a good.Type: GrantFiled: October 6, 2015Date of Patent: September 19, 2017Assignee: Interface Biologics, Inc.Inventors: Jamie Robert Swenor, Mark A. Steedman, Sanjoy Mullick
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Patent number: 9751972Abstract: The invention relates to surface modifying macromolecules (SMMs) having high degradation temperatures and their use in the manufacture of articles made from base polymers which require high temperature processing. The surface modifier is admixed with the base polymer to impart alcohol and water repellency properties.Type: GrantFiled: February 24, 2014Date of Patent: September 5, 2017Assignee: Interface Biologic Inc.Inventors: Sanjoy Mullick, Weilun Chang, Alexandra Piotrowicz, Jeannette Ho, Richard Witmeyer
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Patent number: 9744269Abstract: The invention relates to admixtures of thermoplastic polyurethane base polymers that resist surface dulling and fluorinated additives and their use in the manufacture of articles, such as medical devices. For example, the admixtures of the invention are useful in the manufacture of blood dwelling medical devices, such as catheters.Type: GrantFiled: November 20, 2015Date of Patent: August 29, 2017Assignees: Interface Biologics, Inc., AngioDynamics, Inc.Inventors: J. Paul Santerre, Jeannette Ho, Alexandra Piotrowicz, Roseita Esfand, Raymond Lareau, Benjamin Bell
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Patent number: 9206283Abstract: The invention relates to admixtures of thermoplastic polyurethane base polymers that resist surface dulling and fluorinated additives and their use in the manufacture of articles, such as medical devices. For example, the admixtures of the invention are useful in the manufacture of blood dwelling medical devices, such as catheters.Type: GrantFiled: March 14, 2014Date of Patent: December 8, 2015Assignees: AngioDynamics, Inc., Interface Biologics, Inc.Inventors: J. Paul Santerre, Jeannette Ho, Alexandra Piotrowicz, Roseita Esfand, Raymond Lareau, Benjamin Bell
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Patent number: 8962697Abstract: The invention features biodegradable polymers for the delivery of biologically active agents. The polymers include at least one biologically active agent covalently attached via a polyamide linker susceptible to selective hydrolysis by peptidase enzymes. Hydrolysis of the polyamide linker releases the biologically active agent in vivo.Type: GrantFiled: June 29, 2007Date of Patent: February 24, 2015Assignee: Interface Biologics Inc.Inventors: Frank Laronde, Hanje Chen
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Publication number: 20150025198Abstract: The invention relates to surface modifying macromolecules (SMMs) having high degradation temperatures and their use in the manufacture of articles made from base polymers which require high temperature processing. The surface modifier is admixed with the base polymer to impart alcohol and water repellency properties.Type: ApplicationFiled: February 24, 2014Publication date: January 22, 2015Applicant: Interface Biologics Inc.Inventors: Sanjoy MULLICK, Weilun CHANG, Alexandra PIOTROWICZ, Jeannette HO, Richard WITMEYER
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Patent number: 8900603Abstract: The invention relates to oligofluorinated coatings and their use in drag delivery The oligofluorinated coatings are compositions comprising formula (XVII). These coatings are used in a method of delivering a biologically active agent to a tissue surface in a mammalian tissue This method occurs by contacting the surface with the coating including an oligofluorinated oligomer and a biologically active agent wherein the coating resides on the tissue surface and release the biologically active agent to the tissue surface.Type: GrantFiled: December 20, 2010Date of Patent: December 2, 2014Assignee: Interface Biologics, Inc.Inventors: Roseita Esfand, J. Paul Santerre, Sylvia Tjahyadi, Bernadette Ilagan
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Patent number: 8877062Abstract: The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.Type: GrantFiled: July 12, 2010Date of Patent: November 4, 2014Assignee: Interface Biologics, Inc.Inventors: Sanjoy Mullick, Weilun Chang, Hanje Chen, Mark Steedman, Roseita Esfand
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Patent number: 8784402Abstract: The present invention provides catheter compositions that provide anti-thrombogenic properties while not adversely impacting mechanical properties. All embodiments of the present invention comprise a catheter that comprises a fluoropolymer additive with specific compositions and/or purity levels.Type: GrantFiled: July 25, 2013Date of Patent: July 22, 2014Assignees: AngioDynamics, Inc., Interface Biologics, Inc.Inventors: Raymond Lareau, Benjamin Bell, J. Paul Santerre, Jeannette Ho
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Patent number: 8574604Abstract: The invention features polymers noncovalently complexed with a biologically active agent. The polymer complexes include at least one shielding moiety covalently tethered to at least one complexing moiety, which is complexed with at least one biologically active agent.Type: GrantFiled: April 14, 2006Date of Patent: November 5, 2013Assignee: Interface Biologics, Inc.Inventors: Roseita Esfand, Paul J. Santerre, Meilin Yang
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Patent number: 8445016Abstract: The invention features grafted polymer systems for use in medical devices and/or for the delivery of active agents. The grafted polymers include at least one transport moiety, a linear backbone segment, and a pendant segment.Type: GrantFiled: April 13, 2007Date of Patent: May 21, 2013Assignee: Interface Biologics, Inc.Inventors: J. Paul Santerre, Roseita Esfand, Meilin Yang
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Patent number: 8440176Abstract: The invention relates to graftable polymers comprising biologically active agents and the use of such polymers in the manufacture of shaped articles, such as implantable medical devices and catheters. The graftable polymers are covalently grafted to a surface via one or more grafting moieties incorporated into the pharmaceutically-active graftable polymer. The coated articles of the invention can further comprise tie-coats, and the ratio of polymer:tie coat can be used to adjust the rate of drug elution.Type: GrantFiled: April 24, 2009Date of Patent: May 14, 2013Assignee: Interface Biologics, Inc.Inventors: Frank Laronde, Fan Gu
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Patent number: 8357385Abstract: The invention features a method for treating a subject diagnosed with, or at risk of developing, a bacterial infection by administering to the subject a combination of biologically active agents.Type: GrantFiled: April 7, 2009Date of Patent: January 22, 2013Assignee: Interface Biologics Inc.Inventors: Frank LaRonde, Hanje Chen, Selva Sinnadurai
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Patent number: 8349309Abstract: A pharmaceutically-active polymeric compound of the general formula (I), Y-[Yn-LINK B-X]m-LINK B??(I) wherein (i) X is a coupled biological coupling agent of the general formula (II) Bio-LINK A-Bio??(II) wherein Bio is a biologically active agent fragment or precursor thereof linked to LINK A through a hydrolysable covalent bond; and LINK A is a coupled central flexible linear first segment of <2000 theoretical molecular weight linked to each of said Bio fragments; (ii) Y is LINK B-OLIGO; wherein (a) LINK B is a coupled second segment linking one OLIGO to another OLIGO and an OLIGO to X or precursor thereof; and (b) OLIGO is a short length of polymer segment having a molecular weight of less than 5,000 and comprising less than 100 monomeric repeating units; (iii) m is 1-40; and (iv) n is selected from 2-50. The compounds are useful as biomaterials, particularly, providing antibacterial activity in vivo.Type: GrantFiled: June 3, 2010Date of Patent: January 8, 2013Assignee: Interface Biologics Inc.Inventors: J. Paul Santerre, Mei Li
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Patent number: 8338537Abstract: The invention relates to surface modifying macromolecules (SMMs) having high degradation temperatures and their use in the manufacture of articles made from base polymers which require high temperature processing. The surface modifier is admixed with the base polymer to impart alcohol and water repellency properties.Type: GrantFiled: May 7, 2012Date of Patent: December 25, 2012Assignee: Interface Biologics Inc.Inventors: Sanjoy Mullick, Richard Witmeyer, Paul Santerre, Weilun Chang