Abstract: The invention relates to a composition comprising, from 2 to 8% squalane, from 1.5 to 8% cyclodextrin, and from 1.5 to 8% of a pharmaceutically and/or cosmetically acceptable acid selected from aliphatic mono-, di- and &agr;-hydroxy carboxylic acids having from 2 to 10 carbon atoms, and the balance selected from other pharmaceutically and/or cosmetically acceptable compatible anti-acne active substances as well as pharmaceutically and/or cosmetically acceptable paste, ointment or cream bases and additives. The composition has therapeutic and cosmetic effect and can be used as a cosmetic as well as for the preparation of a drug for prophylactic and curative treatment of acne. A method for the preparation of the composition as well as a method for treatment of acne is also included in the invention.