Abstract: The apparatus for medical purposes comprises a sleeve-type catheter hub (10) having a cylindrical longitudinal channel (11) and a flexible catheter capillary (24) which, through an orifice portion (11a) of the longitudinal channel (11) extends into an expanded intermediate section (11c) of the longitudinal channel (11). The catheter capillary (24) includes a thicker head portion (23) tightened in the expanded intermediate section (11c) of the longitudinal channel (11) by an annular shoulder (22) of a radial annular collar (20) which is formed by ultrasonic welding into the wall of the longitudinal channel (11). To obtain a stepless passage of the cylindrical channel (11), an adapter (18) with a conical passage (19) is joined by press fit to the annular collar (20). The catheter capillary (24) is firmly anchored. In addition, the conical passage (19) serves as an insertion aid for a probe or the like.

Abstract: An injection shut-off valve for insertion into an infusion line comprises a housing with connections for inlet and outlet lines. The housing includes an orifice for introducing an injection syringe. A valve is installed in the housing and includes a deformable diaphragm. In a non-injection state, the valve device seals off fluid flow between the inlet and outlet lines on the one hand and the orifice on the other. During injection, the diaphragm is deformed to create an opening such that fluid flow from the inlet to the housing is shut off. During deformation of the diaphragm the orifice is brought into fluid carrying communication with the outlet line from the housing, thus making it possible for the injection fluid to pass through the housing into the outlet line, and to a patient.

Abstract: The invention comprises heparin derivative compounds which possess a low density lipoprotein lowering action without a significant anticoagulent effect, and are therefore useful in the treatment of disturbances of fat metabolism, especially hyperlipidemia. The heparin derivatives of the invention are derived from natural heparin, and are prepared by the hydrolysis of heparin and optionally, subsequent acylation at free amine groups of the hydrolyzed heparin.

Abstract: A process and device for the selective separation of pathological and/or toxic species from blood, plasma or serum wherein a plasma or serum fraction is passed through a container containing one or more filter candles of decreasing means pore diameter and which may contain a sterilizable spacing disc between the filter candles. In accordance with the invention, macromolecular pathological and/or toxic species with molecular weight exclusion limits between about 20,000 and 3,000,000 D may be selectively separated from a fraction of plasma or serum.

Abstract: The novel safety blood withdrawal device includes as principal components a syringe body (SK) with a cannula holder, a collecting container (AB) which can be pressed into the syringe body, and a continuous tube (R).The collecting container is present in the form of a hollow cylinder (11) with a forwardly fitted, fixed sealing plug (12) of elastic material and with an internally fitted sealing piston (13), which is movable relative to the piston inner wall.The syringe body exhibits at its rear end gripping lugs (21) and at the end face (22) a cannula holder (23).

Abstract: The invention relates to vessel prostheses formed from a porous vascular prosthesis impregnated with diisocyanate crosslinked gelatin for sealing the pores.

Abstract: A dialytic apparatus for single-needle dialysis comprises a first pump in the artery conduit, which first pump in the first phase conveys blood from the patient into the expansion chamber while the vein conduit is shut off. At the same time, the second pump transports blood from the expansion chamber to the dialyzer. This regulation is performed in dependence from the pressure in the vein conduit so that the pressure decrease caused by ultrafiltration is counterbalanced. In the second phase, the first pump stands still and closes the artery conduit while the second pump conveys blood out of the expansion chamber to the dialyzer at a constant rate.

Abstract: A two-cannula syringe for the aspiration and for the injection of medicaments in the form of liquids. The syringe includes a first cannula for the aspiration of the liquid into a cylinder of the syringe and for the possible mixing and/or degassing of the liquid and a second cannula for the actual injection. Both cannulae are present in a protected state, the first cannula being disposed so as to be displaced relative to the second and/or so as to be removable or displaceable in the longitudinal direction of the syringe, and both cannulae being disposed about the same longitudinal axis of the syringe.

Abstract: The dialysis equipment has a dialysate path connectable to a dialysate source 1, and contains a feed pump 6, a dialyzer 10, and a controlled suction pump 13. During the operative phase, this dialysate path is traversed by the dialysate with a constant negative pressure being maintained in the dialysate chamber 101 of the dialyzer 10 relative to the blood chamber 102. In a subsequent measuring phase, the dialysate path is cut off from the dialysate source 1 and from a drain 15 via a valve device 2, 14. The same negative pressure is maintained in the dialysate chamber 101 as in the operative phase. The ultrafiltrate passing from the blood chamber 102 into the dialysate chamber 101 during the measuring phase causes the filling of a volume measuring device 5.

Abstract: An apparatus for hemodiafiltration that maintains the blood concentration of the patient relatively constant. A pump is connected to a branch off the external flow path of the dialysator which pumps fluid to the circulation system of the patient to compensate for the patient's fluid loss through the hemodiafilter membrane. A suction pump which affects the transmembrane pressure across the hemodiafilter membrane is controlled to achieve the desired filtrate flow necessary to balance the return flow to the patient.

Abstract: The sampling device for chemical, in particular biochemical process technics, consists of a sterilizable container in which a magnetic stirring system is accommodated whose agitator beam may be adjusted in height also in operation. Fluid flows through a tangential inlet near the bottom to be discharged through an outlet provided in the upper end wall. Beneath the filter membrane there is an extremely small dead space through which the filtrate gets to the filtrate outlet. The lower end of the agitator arm is designed as a pointed flow break-away edge which, in case of rotation, generates an alternating pressure field migrating over the membrane. The device is particularly characterized by short response times and by a long service life due to the fact that without a substantial shearing, the filter membrane is kept free from deposits.

Abstract: The invention relates to an allosterically active conjugate composition comprising one or more hemoglobin tetramers and one or more adducts of a physiologically safe macromolecular agent covalently linked to one or more ligands, such that the adduct is bound to the allosteric binding site of the hemoglobin in a reversible, non-covalent manner; the invention also relates to methods for producing such conjugate compositions; and to blood substitutes or plasma extenders containing such conjugates.

Abstract: The growth of animal cells in a fermenter is promoted by enriching the liquid nutrient medium or broth with oxygen diffused into the liquid through a permeable membrane, such as one made of silicone rubber or polytetrafluoroethylene (Teflon). Superior cell growth in larger volumes is achieved by feeding in the oxygen in this way instead of bubbling it in.

Abstract: The invention relates to processes and apparatus employing filter candles with an effective filter surface area of 0.2 to 2 square meters and a mean pore diameter of 0.2 to 2 micron in sterilizable cylindrical housings for the selective extracorporeal separation of precipitates of macromolecular pathologic and/or toxic species from blood or blood constituents, such as whole serum or plasma.

Abstract: An apparatus for the production of biocatalyst beads comprises an immobilization vessel (10) which is provided at its lower end with discharge pipes (23) which extend through a pressure chamber (25) in which a gas pressure prevails. The pressure chamber (25) is terminated by a plate (24) exhibiting holes which coaxially surround the discharge pipes (23). At the lower end of the immobilization vessel (10) is provided a connecting nozzle (30) which is connected in germproof sealing manner to the wall of a collecting vessel (11) which contains a solution of a cross-linking agent or a reprecipitation bath. The collecting vessel (11) may be constructed as a fermenter and provided with an agitator. Both of the vessels may be jointly sterilized.

Abstract: A syringe for an injector utilizes a cylinder having a deformable wall portion in the outlet end. Excessive pressure within the syringe cylinder, or contact with the syringe piston at the end of its stroke distends the deformable wall portion of the cylinder, actuating a sensor which provides a signal.

Abstract: A dialysis apparatus utilizes an expansion chamber in parallel with a pump from which the chamber receives blood via a valve. During the return flow phase the pump rotates in the same direction; but, the valve is closed and a valve at the chamber outlet is opened. The pump draws blood from the chamber and transports it to a dialyzer. A control device regulates the pump and valves depending on the time integral of the pump delivery. In each phase, blood is transported until the chamber has received or discharged a predetermined volume. The pump speed is variable during operation.

Abstract: An injector for infusion or transfusion systems utilizes a housing having a duct extending longitudinally therethrough. The inner surface of a penetrable membrane covers an end of the duct, with the edge of the surface abutting an annular shoulder of the housing. A ring is disposed in an annular indentation on the periphery of the outer surface of the membrane, with the outer edge of the inner surface of the ring abutting a second annular shoulder of the housing. The outer surface of the ring and the central portion of the outer surface of the membrane are flush.

Abstract: A stapler, particularly for suturing skin wounds or incisions, is disclosed which comprises a channel in which a driver is advanced by a slide in the direction of an anvil surface. A staple magazine which extends substantially parallel with the driver includes a curved section which opens into the channel to deliver staples into the channel for engagement by the driver. During forward displacement of the driver, a projection on the driver presses a leaf spring to which the anvil surface is connected. The anvil surface at the forward end of the leaf spring is thereby brought into its operating position and is automatically moved back into its retracted position upon release of the spring after the driver is retracted. The curved section in the staple magazine enables the stapler to have a slim profile which does not obscure the working area during a stapling operation. After completion of a stapling operation, the anvil surface is automatically retracted from a closed, implanted staple.