Abstract: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human depression predisposing gene, specifically the apoptotic protease activating factor 1 (APAF1) gene, some mutant alleles of which cause susceptibility to depression. More specifically, the invention relates to germline mutations in the APAF1 gene and their use in the diagnosis of predisposition to depression. The invention also relates to the prophylaxis and/or therapy of depression associated with a mutation in the APAF1 gene. The invention further relates to the screening of drugs for depression therapy. Finally, the invention relates to the screening of the APAF1 gene for mutations/alterations, which are useful for diagnosing the predisposition to depression.
May 17, 2007
July 3, 2008
Intermountain Health Care, Inc.
Donna Shattuck, Deanna Russell, Victor Abkevich, Chris Neff, Lisa Cannon-Albright, Nicola Camp
Abstract: Method and apparatus for determining the gaseous content of a diluent, such as determining the oxygen or carbon dioxide content of blood. A sample of the diluent whose gaseous content is to be measured is anaerobically pumped past a junction tee after being placed in a reservoir. A second diluent, not part of the sample, is equilibrated with a gas (not the gas to be measured) in a first tonometer. This second equilibrated diluent is pumped past the junction tee where it is mixed with the diluent sample. The gas in the second diluent is selectively chosen to drive the gas to be measured into the dissolved phase. The diluent mixture is then allowed to flow through an appropriate sensor that senses the presence of the gas to be measured. This first measurement is stored in a suitable controller, such as a microprocessor.
Abstract: A non-invasive cyclic injection method for determining pulmonary blood flow, the ventilation-perfusion distribution and functional residual capacity, which consists of the non-invasive cyclical introduction of soluble and insoluble inert gases into the airstream of the human patient, each period of introduction followed by a similar period free from the introduction of soluble inert gases to allow for the washout of their concentrated buildup in the venous system. Sampling and analysis of expired air during all parts of the cyclic injection and non-injection of gases takes place with the results being electronically obtained and translated into digital data indicative of the parameter being determined.
Abstract: Method and system for sampling and determining chemical substances such as blood gases, in a fluid matrix, such as blood, by bringing the chemical substances into equilibrium with a liquid in a fiber probe, passing the equilibrated liquid to a sensor adjacent the equilibrium region and on into a hollow fiber line enclosed in a calibration chamber. Calibration of the sensors is accomplished by reversing the flow of liquid from the hollow fiber line to the sensors. In the system chemical substances for sensor calibration are provided by an electric proportioner whose output is continuously controlled by the output of the sensors such that the substances proportioned into a fluid in the calibration chamber surrounding the hollow fiber line are substantially the same as the substances within the matrix. The concentration of substances is determined by the output of the sensors and the amount of substances fed from the proportioner to the fluid surrounding the hollow fiber line.
December 23, 1977
Date of Patent:
September 9, 1980
Intermountain Health Care
Justin S. Clark, William D. Wallace, Frederick L. Farr
Abstract: A non-airtight method for determining alveolar ventilation, oxygen uptake and carbon dioxide production which comprises introducing a known amount of an inert gas into the airway of a patient during inspiration and monitoring the expired gas until a steady state is reached wherein the volume of inert gas inhaled is equal to the amount exhaled and subsequently monitoring the expired air containing a known volume of inert gas for inert gas, carbon dioxide and oxygen concentrations.
June 29, 1978
Date of Patent:
September 9, 1980
Intermountain Health Care, Primary Children's Medical Center
Abstract: An alveolar gas sampling system comprises a catheter adapted for placement in a patient's nostril or in an endotracheal tube and connected to a positive displacement pump through a three way valve. Signal means for detecting onset of inspiration and expiration is mounted at the tip of the catheter and connected to a controller. The positive displacement pump is driven by a reversible stepper motor actuated by the controller during the flow of alveolar air. When the desired amount of alveolar gas has been sampled, the stepper motor is reversed and the position of the valve is switched by the controller causing the alveolar gas collected in the positive displacement pump to be expelled for analysis.