Patents Assigned to InteRNA Technologies B.V.
  • miRNA-193a for Promoting Immunogenic Cell Death
    Publication number: 20230136088
    Abstract: The invention relates to the use of miRNA-193a for regulating gene expression, particularly it relates to the use of miRNA-193a as a CRT agonist, promoting the cell surface expression of CRT. This allows the advantageous treatment of cancers without or with low surface expression of CRT. The invention further relates to compositions comprising the miRNA for use in such treatment.
    Type: Application
    Filed: February 26, 2021
    Publication date: May 4, 2023
    Applicant: INTERNA TECHNOLOGIES B.V.
    Inventors: Sanaz YAHYANEJAD, Bryony TELFORD, Marion VAN DEN BOSCH, Mir Farshid ALEMDEHY, Matheus Maria DE GUNST, Laurens Adrianus Hendricus VAN PINXTEREN, Roeland Quirinus Jozef SCHAAPVELD, Michel JANICOT
  • MiRNA molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
    Patent number: 11497762
    Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a neuronal deficiency or a disease and condition associated with neuronal deficiency.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: November 15, 2022
    Assignee: INTERNA TECHNOLOGIES B.V.
    Inventors: Eljo Y. Van Battum, Vamshi R. Vangoor, Alwin A. H. A. Derijck, Roeland Quirinus Jozef Schaapveld, R. Jeroen Pasterkamp
  • NEW TREATMENTS INVOLVING MIRNA-193A
    Publication number: 20220275368
    Abstract: The invention relates to the use of miRNA-193a for regulating gene expression, particularly it relates to the use of miRNA-193a as a PTEN agonist. This allows the advantageous treatment of PTEN-deficient cancers. The invention further relates to compositions comprising the miRNA for use as a PTEN agonist.
    Type: Application
    Filed: March 6, 2020
    Publication date: September 1, 2022
    Applicant: INTERNA TECHNOLOGIES B.V.
    Inventors: Sanaz YAHYANEJAD, Bryony Jane TELFORD, Marion Tina Jolien VAN DEN BOSCH, Mir Farshid ALEMDEHY, Matheus Maria DE GUNST, Laurens Adrianus Hendricus VAN PINXTEREN, Roeland Quirinus Jozef SCHAAPVELD, Michel JANICOT
  • MIRNA MOLECULE, EQUIVALENT, ANTAGOMIR, OR SOURCE THEREOF FOR TREATING AND/OR DIAGNOSING A CONDITION AND/OR A DISEASE ASSOCIATED WITH NEURONAL DEFICIENCY OR FOR NEURONAL (RE)GENERATION
    Publication number: 20210315917
    Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a neuronal deficiency or a disease and condition associated with neuronal deficiency.
    Type: Application
    Filed: November 2, 2018
    Publication date: October 14, 2021
    Applicant: INTERNA TECHNOLOGIES B.V.
    Inventors: Eljo Y. VAN BATTUM, Vamshi R. VANGOOR, Alwin A.H.A. DERIJCK, Roeland Quirinus Jozef SCHAAPVELD, R. Jeroen PASTERKAMP
  • ANTICANCER MICRORNA AND LIPID FORMULATIONS THEREOF
    Publication number: 20210038732
    Abstract: The present invention relates to a lipid formulation comprising microRNA. The formulation comprises cationic lipids that can form lipid nanoparticles with the microRNA. The formulations are useful in medicine.
    Type: Application
    Filed: February 12, 2019
    Publication date: February 11, 2021
    Applicant: INTERNA TECHNOLOGIES B.V.
    Inventors: Matheus Maria DE GUNST, Laurens Adrianus Hendricus VAN PINXTEREN, Michel JANICOT, Iman Johannes SCHULTZ, Roeland Quirinus Jozef SCHAAPVELD, Sanaz YAHYANEJAD
  • MIRNA MOLECULE, EQUIVALENT, ANTAGOMIR, OR SOURCE THEREOF FOR TREATING AND/OR DIAGNOSING A CONDITION AND/OR A DISEASE ASSOCIATED WITH NEURONAL DEFICIENCY OR FOR NEURONAL (RE)GENERATION
    Publication number: 20200352978
    Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a neuronal deficiency or a disease and condition associated with neuronal deficiency.
    Type: Application
    Filed: November 3, 2017
    Publication date: November 12, 2020
    Applicant: INTERNA TECHNOLOGIES B.V.
    Inventors: Eljo Y. VAN BATTUM, Vamshi R. VANGOOR, Alwin A.H.A. DERIJCK, Roeland Quirinus Jozef SCHAAPVELD, R. Jeroen PASTERKAMP
  • Combination for use in treating diseases or conditions associated with melanoma, or treating diseases or conditions associated with activated B-raf pathway
    Patent number: 10201556
    Abstract: The invention relates to the therapeutic use of a combination in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: February 12, 2019
    Assignee: INTERNA TECHNOLOGIES B.V.
    Inventors: Rick Jan van Haastert, Petronella Innocentia van Noort, Grégoire Pierre André Prevost, Willemijn Maria Gommans, Roeland Quirinus Jozef Schaapveld, Matheus Maria De Gunst, Iman Johannes Schultz, Eugene Berezikov
  • MiRNA for treating head and neck cancer
    Patent number: 10174314
    Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA-323, miRNA-342, miRNA-326, miRNA-371, miRNA-3157 and/or miRNA-345 molecule, an equivalent or a source thereof in a disease and condition associated with a squamous cell carcinoma such as head and neck cancer or a preneoplastic mucosal change.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: January 8, 2019
    Assignees: INTERNA TECHNOLOGIES B.V., VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
    Inventors: Rudolf Henrikus Brakenhoff, Marlon Van Der Plas, Sanne Rosaly De Kemp, Willemijn Maria Gommans, Grégoire Pierre André Prevost, Roeland Quirinus Jozef Schaapveld, Francesco Cerisoli
  • MiRNA for treating diseases and conditions associated with neo-angiogenesis
    Patent number: 10023868
    Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: July 17, 2018
    Assignee: INTERNA TECHNOLOGIES B.V.
    Inventors: Sanne Weijzen, Roeland Quirinus Jozef Schaapveld, Meriem Bourajjaj, Rick Jan Van Haastert, Arjan Willem Griffioen, Judith Rosina Van Beijnum, Edwin Pieter Johan Gerard Cuppen, Eugene Berezikov, Andreas Alphons Franciscus Ludovicus Van Puijenbroek, Willemijn Maria Gommans, Negar Babae, Petronella Innocentia Van Noort
  • MiRNA molecule defined by its source and its diagnostic and therapeutic uses in diseases or conditions associated with EMT
    Patent number: 9944932
    Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule or an equivalent thereof wherein a source of said miRNA molecule or equivalent thereof comprises at least 80 nucleotides and comprises a motif having at least 98% identity with the motif represented by SEQ ID NO:1 or a source thereof in a disease and condition associated with EMT (Epithelial to Mesenchymal Transition).
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: April 17, 2018
    Assignee: INTERNA TECHNOLOGIES B.V.
    Inventors: Roeland Quirinus Jozef Schaapveld, Gerardus Wilhelmus Christiaan Theodoor Verhaegh, Jacobus Antonius Schalken, Andreas Alphons Franciscus Ludovicus van Puijenbroek, Willemijn Maria Gommans, Sanne Weijzen
  • MiRNA and its Diagnostic and Therapeutic Uses in Diseases or Conditions Associated with Melanoma, or in Diseases or Conditions Associated with Activated BRAF Pathway
    Publication number: 20170304348
    Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.
    Type: Application
    Filed: June 16, 2017
    Publication date: October 26, 2017
    Applicants: INTERNA TECHNOLOGIES B.V., KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN
    Inventors: Eugene Berezikov, Jos Bernard Poell, Willemijn Maria Gommans, Rick Jan van Haastert, Andreas Alphons F.L. van Puijenbroek, Roeland Quirinus Jozef Schaapveld, Gregoire Pierre Andre Prevost
  • MiRNA and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated BRAF pathway
    Patent number: 9682095
    Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: June 20, 2017
    Assignee: INTERNA TECHNOLOGIES B.V.
    Inventors: Eugene Berezikov, Jos Bernard Poell, Willemijn Maria Gommans, Rick Jan van Haastert, Andreas Alphons F. L. van Puijenbroek, Roeland Quirinus Jozef Schaapveld, Gregoire Pierre Andre Prevost
  • BIOMARKER FOR COLORECTAL CANCER
    Publication number: 20170130277
    Abstract: Methods of diagnosing colorectal cancer and precursors thereof using miRNA biomarkers are disclosed, together with kits and devices for detecting the biomarkers, and uses of the biomarkers. The biomarkers described are reliably detected in stool and demonstrate significantly different expression levels in colorectal cancer patients when compared to colorectal cancer negative patients.
    Type: Application
    Filed: June 19, 2015
    Publication date: May 11, 2017
    Applicants: STICHTING VU-VUMC, INTERNA TECHNOLOGIES B.V.
    Inventors: Gerrit Albert MEIJER, Begoña DIOSDADO, Lisette M. TIMMER, Edwin Pieter Johan Gerard CUPPEN, Eugene BEREZIKOV, Francesco CERISOLI, Roeland Quirinus Jozef SCHAAPVELD
  • MIRNA FOR TREATING DISEASES AND CONDITIONS ASSOCIATED WITH NEO-ANGIOGENESIS
    Publication number: 20160333353
    Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.
    Type: Application
    Filed: August 3, 2016
    Publication date: November 17, 2016
    Applicant: INTERNA TECHNOLOGIES B.V.
    Inventors: Sanne WEIJZEN, Roeland Quirinus Jozef SCHAAPVELD, Meriem BOURAJJAJ, Rick Jan VAN HAASTERT, Arjan Willem GRIFFIOEN, Judith Rosina VAN BIEJNUM, Edwin Pieter Johan Gerard CUPPEN, Eugene BEREZIKOV, Andreas Alphons Franciscus Ludovicus VAN PIUJENBROEK, Willemijn Maria GOMMANS, Negar BABAE, Petronella Innocentia VAN NOORT
  • MiRNA for treating diseases and conditions associated with neo-angiogenesis
    Patent number: 9441222
    Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: September 13, 2016
    Assignee: INTERNA TECHNOLOGIES B.V.
    Inventors: Sanne Weijzen, Roeland Quirinus Jozef Schaapveld, Meriem Bourajjaj, Rick Jan Van Haastert, Arjan Willem Griffioen, Judith Rosina Van Biejnum, Edwin Pieter Johan Gerard Cuppen, Eugene Berezikov, Andreas Alphons Franciscus Ludovicus Van Piujenbroek, Willemijn Maria Gommans, Negar Babae, Petronella Innocentia Van Noort
  • MiRNA molecule defined by its source and its diagnostic and therapeutic uses in diseases or conditions associated with EMT
    Publication number: 20160017338
    Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule or an equivalent thereof wherein a source of said miRNA molecule or equivalent thereof comprises at least 80 nucleotides and comprises a motif having at least 98% identity with the motif represented by SEQ ID NO:1 or a source thereof in a disease and condition associated with EMT (Epithelial to Mesenchymal Transition).
    Type: Application
    Filed: September 10, 2015
    Publication date: January 21, 2016
    Applicant: INTERNA TECHNOLOGIES B.V.
    Inventors: Roeland Quirinus Jozef SCHAAPVELD, Gerardus Wilhelmus Christiaan Theodoor VERHAEGH, Jacobus Antonius SCHALKEN, Andreas Alphons Franciscus Ludovicus van PUIJENBROEK, Willemijn Maria GOMMANS, Sanne WEIJZEN
  • Combination for use in treating diseases or conditions associated with melanoma, or treating diseases or conditions associated with activated B-raf pathway
    Publication number: 20150297626
    Abstract: The invention relates to the therapeutic use of a combination in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.
    Type: Application
    Filed: November 6, 2013
    Publication date: October 22, 2015
    Applicant: InteRNA Technologies B.V.
    Inventors: Rick Jan van Haastert, Petronella Innocentia van Noort, Grégoire Pierre André Prevost, Willemijn Maria Gommans, Roeland Quirinus Jozef Schaapveld, Matheus Maria De Gunst, Iman Johannes Schultz, Eugene Berezikov
  • MiRNA molecule defined by its source and its diagnostic and therapeutic uses in diseases or conditions associated with EMT
    Patent number: 9161947
    Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule or an equivalent thereof wherein a source of said miRNA molecule or equivalent thereof comprises at least 80 nucleotides and comprises a motif having at least 98% identity with the motif represented by SEQ ID NO:1 or a source thereof in a disease and condition associated with EMT (Epithelial to Mesenchymal Transition).
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: October 20, 2015
    Assignee: INTERNA TECHNOLOGIES B.V.
    Inventors: Roeland Quirinus Jozef Schaapveld, Gerardus Wihelmus Christiaan Theodoor Verhaegh, Jacobus Antonius Schalken, Andreas Alphons van Puijenbroek, Willemjin Maria Gommans, Sanne Weijzen
  • MIRNA FOR TREATING HEAD AND NECK CANCER
    Publication number: 20150225716
    Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA-323, miRNA-342, miRNA-326, miRNA-371, miRNA-3157 and/or miRNA-345 molecule, an equivalent or a source thereof in a disease and condition associated with a squamous cell carcinoma such as head and neck cancer or a preneoplastic mucosal change.
    Type: Application
    Filed: December 20, 2012
    Publication date: August 13, 2015
    Applicant: INTERNA TECHNOLOGIES B.V.
    Inventors: Rudolf Henrikus Brakenhoff, Marlon Van Der Plas, Sanne Rosaly De Kemp, Willemijn Maria Gommans, Grégoire Pierre André Prevost, Roeland Quirinus Jozef Schaapveld, Francesco Cerisoli
  • DIAGNOSTIC PORTFOLIO AND ITS USES
    Publication number: 20150152499
    Abstract: A diagnostic portfolio comprising or consisting of isolated nucleic acid molecules, their complement and/or fragments thereof, said nucleic acid molecules, complements, equivalents and/or fragments thereof being represented by sequences comprising or consisting of sequences having at least 80% of sequence identity with SEQ ID NO:1-92, or 49-140 or derived thereof (i.e. groups a), b), c), d), e), f), g), h), i) or j) or subgroups thereof) and their uses.
    Type: Application
    Filed: July 3, 2013
    Publication date: June 4, 2015
    Applicant: InteRNA Technologies B.V.
    Inventors: Anton Jan Van Zonneveld, Jacques Duijs, Johan Kuiper, Thijs Jan Zweers, Johan Wouter Jukema, Eugene Berezikov