Abstract: The invention relates to the therapeutic use of a combination in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.
Abstract: A diagnostic portfolio comprising or consisting of isolated nucleic acid molecules, their complement and/or fragments thereof, said nucleic acid molecules, complements, equivalents and/or fragments thereof being represented by sequences comprising or consisting of sequences having at least 80% of sequence identity with SEQ ID NO:1-92, or 49-140 or derived thereof (i.e. groups a), b), c), d), e), f), g), h), i) or j) or subgroups thereof) and their uses.
Type:
Application
Filed:
July 3, 2013
Publication date:
June 4, 2015
Applicant:
InteRNA Technologies B.V.
Inventors:
Anton Jan Van Zonneveld, Jacques Duijs, Johan Kuiper, Thijs Jan Zweers, Johan Wouter Jukema, Eugene Berezikov
Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.
Type:
Application
Filed:
July 2, 2013
Publication date:
January 2, 2014
Applicant:
InteRNA Technologies B.V.
Inventors:
Sanne WEIJZEN, Roeland Quirinus Jozef SCHAAPVELD, Meriem BOURAJJAJ, Rick Jan VAN HAASTERT, Arjan Willem GRIFFIOEN, Judith Rosina VAN BEIJNUM, Edwin Pieter Johan Gerard CUPPEN, Eugene BEREZIKOV, Andreas Alphons Franciscus Ludovicus VAN PUIJENBROEK, Willemijn Maria GOMMANS, Negar BABAE, Petronella Innocentia VAN NOORT
Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.
Type:
Application
Filed:
January 4, 2013
Publication date:
May 2, 2013
Applicants:
Koninklijke Nederlandse Akademie van Wetenschappen, InteRNA Technologies B.V.
Inventors:
InteRNA Technologies B.V., Koninklijke Nederlandse Akademie van Wetensch
Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule or an equivalent thereof wherein a source of said miRNA molecule or equivalent thereof comprises at least 80 nucleotides and comprises a motif having at least 98% identity with the motif represented by SEQ ID NO:1 or a source thereof in a disease and condition associated with EMT (Epithelial to Mesenchymal Transition).
Type:
Application
Filed:
September 4, 2012
Publication date:
March 21, 2013
Applicant:
InteRNA Technologies B.V.
Inventors:
Roeland Quirinus Jozef Schaapveld, Gerardus Wilhelmus Christiaan Theodoor Verhaegh, Jacobus Antonius Schalken, Andreas Alphons Franciscus Ludovicus Van Puijenbroek, Willemjin Maria Gommans, Sanne Weijzen