Abstract: A method for adaptively compensating skews during data transmission on a bus is disclosed. A bus includes one or more groups of multiple signal paths. Each of the signal paths within a group is assigned a unique binary data value. During data transmissions, only one signal path within each group is activated at a time, and each activation of one of the signal paths represents its associated unique binary data value. Thus, a sequence of consecutive activations represents the same information as if the data were transmitted in parallel. Before signal transmission, a time delay between a transition on a first and a second of the signal lines is measured by utilizing a control frame. The time delay measurement is repeated to establish the relative time delays associated with all possible transitions on all the signal lines. In response to the measured time delays, an appropriate compensating delay is introduced accordingly before launching each transition on the signal lines.