Patents Assigned to International Centre For Genetic Engineering and Biotechnology Trieste
  • Patent number: 5932426
    Abstract: The invention refers to a molecular presentation system in which viral proteins are foreseen as carriers for heterologous amino acid sequences. Hereby, the viral protein is derived from small insect viruses, primarily from Flock House Virus (FHV), with a known 3-dimensional structure and amino acid sequence, whereby heterologous amino acid sequences, for example epitopes, are inserted in the outwardly directed loops of the viral capsid protein. Moreover, the expression of the FHV capsid protein in insect cells can produce mature virus like particles (VLP) through a recombinant baculovirus.
    Type: Grant
    Filed: March 31, 1997
    Date of Patent: August 3, 1999
    Assignee: International Centre For Genetic Engineering and Biotechnology Trieste
    Inventors: Francesco Ernesto Baralle, Eduardo Scodeller, Sergio Tisminetzky