Patents Assigned to International Society for Drug Development S.R.L.
  • NOVEL THYROMIMETICS WITH A BIPHENYLMETHANE SCAFFOLD AND THEIR USE
    Publication number: 20220227698
    Abstract: The invention concerns a compound of Formula (I) or a salt thereof, wherein R1 is H, (C1-C3)alkyl or CF3; R2 is H, (C1-C3)alkyl or CF3; A is CH2COOH, XCH2COOCH2CH3, XCH2COOH, XCH2CH2NH2, where X is nitrogen or oxygen atom; Ar is an aromatic fragment selected from the group consisting of (Ar1), (Ar2) and (Ar3); where R3 is H, —CH3, —CH2CH3 or CH3CO—, R4 is H or —CH3, R5 is H or —CH3, and R6 is H or —CH3. The compounds of Formula (I) can be used in the treatment of diseases modulated by thyroid hormone receptor-beta (TRb or TR?).
    Type: Application
    Filed: March 10, 2020
    Publication date: July 21, 2022
    Applicant: INTERNATIONAL SOCIETY FOR DRUG DEVELOPMENT S.R.L.
    Inventors: Guido Puricelli, Simona Rapposelli, Grazia Chiellini, Amedeo Columbano, Andrea Perra, Massimiliano Runfola, Sheraz Gul
  • H2S-BASED THERAPEUTIC AGENTS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20210070730
    Abstract: The present invention concerns the field of neurodegenerative diseases, and in particular relates to compounds, pharmaceutical compositions and their uses in the protection of neuronal cells from inflammation and from oxidative stress in the early stage of Parkinson's Disease as well as in Alzheimer's Disease.
    Type: Application
    Filed: October 8, 2018
    Publication date: March 11, 2021
    Applicant: INTERNATIONAL SOCIETY FOR DRUG DEVELOPMENT S.R.L.
    Inventors: Simona Rapposelli, Simona Sestito, Vincenzo Calderone, Guido Puricelli
  • 2-oxo-1,2-dihydropyridine-3-carboxamide compounds and their use as inhibitors of PDK1
    Patent number: 10351548
    Abstract: The present invention concern a 2-oxo-1,2-dihydropyridine-3-carboxamide compound of Formula (I) and new 2-oxo-1,2-dihydropyridine-3-carboxamide compounds of Formula (II) in the treatment of pathologies which require an inhibitor of PDK1 enzyme such as diabetes, neurodegenerative diseases such as Alzheimer's and Prion Diseases, and tumors such as breast, and pancreatic cancers and glioblastoma, particularly glioblastoma.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: July 16, 2019
    Assignee: International Society for Drug Development S.R.L.
    Inventors: Simona Sestito, Simona Daniele, Claudia Martini, Simona Rapposelli, Guido Puricelli