Abstract: Disclosed herein are methods for treating Barrett's metaplasia and esophageal adenocarcinoma and methods for determining mutational load as a predictor of the risk of disease progression from Barrett's metaplasia to esophageal adenocarcinoma.
Type:
Grant
Filed:
February 26, 2019
Date of Patent:
January 21, 2025
Assignee:
Interpace Diagnostics Corporation
Inventors:
Eric Matthew Gayle Ellsworth, Sydney David Finkelstein, Sara Ann Jackson, Brendan Corcoran, Dennis Morgan Smith
Abstract: The application relates to a method of a predicting the presence of invasive pancreatic cancer or high grade dysplasia, pre-cancerous pancreatic states and non-neoplastic conditions comprising detailed molecular analysis incorporating DNA quality and quantity, K-ras mutational analysis and a broad spectrum of tumor suppressor gene linked microsatellite LOH. Methods of diagnosing, determining prognosis of and determining a course of treatment for pancreatic cancer or high grade dysplasia, pre-cancerous pancreatic states and non-neoplastic conditions are also provided.
Type:
Grant
Filed:
March 6, 2018
Date of Patent:
October 12, 2021
Assignee:
Interpace Diagnostics Corporation
Inventors:
Sydney David Finkelstein, Patricia Swalsky
Abstract: Disclosed herein are methods of accurately measuring carcinoembryonic antigen in a biological sample and methods of identifying and treating a mucinous cyst in a subject.
Type:
Grant
Filed:
May 6, 2016
Date of Patent:
October 15, 2019
Assignee:
INTERPACE DIAGNOSTICS CORPORATION
Inventors:
Sydney David Finkelstein, Sara Ann Jackson, Jamie Michelle Bleicher, Eric Matthew Gayle Ellsworth, Dennis Morgan Smith, Jr.
Abstract: Disclosed herein are methods for treating Barrett's metaplasia and esophageal adenocarcinoma and methods for determining mutational load as a predictor of the risk of disease progression from Barrett's metaplasia to esophageal adenocarcinoma.
Type:
Grant
Filed:
December 3, 2012
Date of Patent:
April 9, 2019
Assignee:
INTERPACE DIAGNOSTICS CORPORATION
Inventors:
Eric Matthew Gayle Ellsworth, Sydney David Finkelstein, Sara Ann Jackson, Brendan Corcoran, Dennis Morgan Smith, Jr.
Abstract: Disclosed herein are methods for treating Barrett's metaplasia and esophageal adenocarcinoma and methods for determining mutational load as a predictor of the risk of disease progression from Barrett's metaplasia to esophageal adenocarcinoma.
Type:
Grant
Filed:
July 30, 2013
Date of Patent:
November 20, 2018
Assignee:
INTERPACE DIAGNOSTICS CORPORATION
Inventors:
Eric Matthew Gayle Ellsworth, Sydney David Finkelstein, Sara Ann Jackson, Brendan Corcoran, Dennis Morgan Smith, Jr.
Abstract: Disclosed herein are methods of accurately measuring carcinoembryonic antigen in a biological sample and methods of identifying and treating a mucinous cyst in a subject.
Type:
Grant
Filed:
November 27, 2013
Date of Patent:
May 17, 2016
Assignee:
INTERPACE DIAGNOSTICS CORPORATION
Inventors:
Sydney David Finkelstein, Sara Ann Jackson, Jamie Michelle Bleicher, Eric Matthew Gayle Ellsworth, Dennis Morgan Smith, Jr.