Patents Assigned to Interventional Autonomics Corporation
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Publication number: 20200206512Abstract: A method of treating a patient having a blood pressure comprises delivering neuromodulation therapy to sustain or increase the blood pressure. The neuromodulation therapy includes placing a sympathetic therapy electrode in a posterior portion of a blood vessel and stimulating at least one extravascular cardiac sympathetic nerve fiber using said electrode.Type: ApplicationFiled: August 8, 2019Publication date: July 2, 2020Applicant: Interventional Autonomics CorporationInventors: Stephen C. Masson, Terrance Ransbury, Richard S. Stack, William E. Sanders
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Publication number: 20190374778Abstract: A neuromodulation catheter is positionable in a blood vessel having a wall for use in delivering therapeutic energy to targets external to the blood vessel. An electrically insulative substrate such as an elongate finger is carried at a distal end of the catheter body. The substrate has a first face carrying a plurality of electrodes, and a second face on an opposite side of the substrate from the first face. The finger is biased such that when expanded within the blood vessel, it forms a spiral configuration with the first face facing outwardly to bias the electrodes in contact with the blood vessel wall.Type: ApplicationFiled: August 8, 2019Publication date: December 12, 2019Applicant: Interventional Autonomics CorporationInventors: Stephen C. Masson, Jeffrey A. Smith
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Publication number: 20180117305Abstract: A neuromodulation system includes a first therapy element adapted for positioning within a superior vena cava, and a second therapy element adapted for positioning within a pulmonary artery. The first therapy element is carried on a first elongate flexible shaft, and the second therapy element is carried on a second elongate flexible shaft. One of the first and second shafts is slidably received within a lumen of the other of the first and second shafts—so that the second therapy element may be advanced within the body relative to the first therapy element. A stimulator is configured to energize the first therapy element within the first blood vessel to deliver therapy to a first nerve fiber disposed external to the superior vena cava and to energize the second therapy element within the pulmonary artery to deliver sympathetic therapy to a second nerve fiber disposed external to the pulmonary artery.Type: ApplicationFiled: December 27, 2017Publication date: May 3, 2018Applicant: Interventional Autonomics CorporationInventors: Terrance J. Ransbury, Richard S. Stack, William E. Sanders, Stephen C. Masson
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Patent number: 9884182Abstract: A neuromodulation system includes a first therapy element adapted for positioning within a superior vena cava, and a second therapy element adapted for positioning within a pulmonary artery. The first therapy element is carried on a first elongate flexible shaft, and the second therapy element is carried on a second elongate flexible shaft. One of the first and second shafts is slidably received within a lumen of the other of the first and second shafts—so that the second therapy element may be advanced within the body relative to the first therapy element. A stimulator is configured to energize the first therapy element within the first blood vessel to deliver therapy to a first nerve fiber disposed external to the superior vena cava and to energize the second therapy element within the pulmonary artery to deliver sympathetic therapy to a second nerve fiber disposed external to the pulmonary artery.Type: GrantFiled: January 9, 2014Date of Patent: February 6, 2018Assignee: INTERVENTIONAL AUTONOMICS CORPORATIONInventors: Terrance J Ransbury, Richard S Stack, William E Sanders, Stephen C Masson
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Patent number: 9545512Abstract: The present application describes a retention device for anchoring a medical device within the vasculature. The device may include expandable member coupled to an intravascular medical device and proportioned for receipt within a vessel. At least a portion of the expandable member is expandable to radially engage a vessel wall and to thereby retain the medical device within the vessel. The system is suitable for a variety of intravascular devices, including but not limited to ICD's, pacemakers, and intravascular drug delivery systems.Type: GrantFiled: April 25, 2014Date of Patent: January 17, 2017Assignee: INTERVENTIONAL AUTONOMICS CORPORATIONInventors: Michael S Williams, Terrance Ransbury, Richard A Glenn, Kevin Holbrook
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Publication number: 20160354607Abstract: A method of treating a patient having a blood pressure comprises delivering neuromodulation therapy to sustain or increase the blood pressure. The neuromodulation therapy includes placing a sympathetic therapy electrode in a posterior portion of a blood vessel and stimulating at least one extravascular cardiac sympathetic nerve fiber using said electrode.Type: ApplicationFiled: August 16, 2016Publication date: December 8, 2016Applicant: Interventional Autonomics CorporationInventors: Stephen C. Masson, Terrance Ransbury, Richard S. Stack, William E. Sanders
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Patent number: 9446240Abstract: A method of treating autonomic imbalance in a patient includes energizing a first therapeutic element disposed to deliver therapy to a parasympathetic nerve fiber (e.g. vagus nerve), and energizing a second therapeutic element to deliver therapy to a sympathetic cardiac nerve fiber. At least one of the therapeutic elements is disposed in the vasculature superior to the heart. The therapy decreases the patient's heart rate and elevates or maintains the blood pressure of the patient.Type: GrantFiled: October 17, 2014Date of Patent: September 20, 2016Assignee: INTERVENTIONAL AUTONOMICS CORPORATIONInventors: Stephen C Masson, Terrance Ransbury, Richard S Stack, William E Sanders
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Patent number: 9126048Abstract: A neuromodulation system for treating acute heart failure syndromes includes a first catheter having a parasympathetic therapy element adapted for positioning within a first blood vessel such as a superior vena cava, and a second catheter sympathetic therapy element adapted for positioning with a second, different, blood vessel such as the pulmonary artery. The catheters comprise a system in which one of catheters is slidably disposed over the other of the catheters. The system may further be slidably disposed over a third elongate element such as a Swan-Ganz catheter positionable within a pulmonary artery, such that the Swan-Ganz may be used for monitoring parameters such as blood pressure and cardiac output during neuromodulation therapy.Type: GrantFiled: October 28, 2013Date of Patent: September 8, 2015Assignee: INTERVENTIONAL AUTONOMICS CORPORATIONInventors: Terrance J Ransbury, William E Sanders, Richard S Stack, Colleen Stack
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Patent number: 9067071Abstract: A method of treating autonomic imbalance in a patient includes energizing a first therapeutic element disposed in a superior vena cava of the patient to deliver therapy to a parasympathetic nerve fiber (e.g. vagus nerve), and energizing a second therapeutic element disposed within the superior vena cava to deliver therapy to a sympathetic cardiac nerve fiber. A neuromodulation system includes a parasympathetic therapy element adapted for positioning within a blood vessel, a sympathetic therapy element adapted for positioning within the blood vessel; and a stimulator to energize the parasympathetic therapy element to deliver parasympathetic therapy to a parasympathetic nerve fiber disposed external to the blood vessel and energize the sympathetic therapy element within the blood vessel to deliver sympathetic therapy to a sympathetic nerve fiber disposed external to the blood vessel. The therapy decreases the patient's heart rate and elevates or maintains the blood pressure of the patient.Type: GrantFiled: July 11, 2012Date of Patent: June 30, 2015Assignee: Interventional Autonomics CorporationInventors: William E. Sanders, Stephen C. Masson, Terrance Ransbury, Richard S. Stack
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Patent number: 8972015Abstract: An intravascular electrode system includes an expandable anchor and a flexible substrate which carries at least one electrode. The anchor is positioned in a blood vessel and expanded to an expanded position to bias the electrode in contact with the vessel wall. The flexible substrate may be longitudinally withdrawn from its position between the anchor and the vessel wall without removing the anchor from the blood vessel. A second flexible substrate may be longitudinally inserted into position between the anchor and vessel wall as replacement for the first substrate.Type: GrantFiled: April 23, 2013Date of Patent: March 3, 2015Assignee: Interventional Autonomics CorporationInventors: Richard S. Stack, Michael S. Williams, Daniel W. Fifer, Richard A. Glenn, Geoffrey A Orth, Lynn Elliott, Colleen Stack
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Publication number: 20150018908Abstract: The present application describes a retention device for anchoring a medical device within the vasculature. The device may include expandable member coupled to an intravascular medical device and proportioned for receipt within a vessel. At least a portion of the expandable member is expandable to radially engage a vessel wall and to thereby retain the medical device within the vessel. The system is suitable for a variety of intravascular devices, including but not limited to ICD's, pacemakers, and intravascular drug delivery systems.Type: ApplicationFiled: April 25, 2014Publication date: January 15, 2015Applicant: Interventional Autonomics CorporationInventors: Michael S. Williams, Terrance Ransbury, Richard A. Glenn, Kevin Holbrook
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Patent number: 8934956Abstract: An intravascular electrode device for use in neuromodulation includes an anchor expandable from a radially compressed position to a radially expanded position. A lead extends from the anchor and has at least one conductor extending through it. A flex circuit is coupled to the anchor and comprises a flexible insulative substrate, a plurality of electrodes carried by the substrate, and a plurality of conductive traces carried by the substrate, each trace electrically coupled to an electrode and a conductor. Expansion of the anchor within a blood vessel biases the electrodes into contact with the surrounding blood vessel wall. An exemplary anchor includes a first portion having expansion forces sufficient to bias the electrodes against the vessel wall for mapping and chronic stimulation, and a second portion having greater radial expansion forces sufficient to chronically engage the vessel wall once an optimal electrode location has been selected.Type: GrantFiled: October 25, 2011Date of Patent: January 13, 2015Assignee: Interventional Autonomics CorporationInventors: Richard A. Glenn, Jeffrey A. Smith, Geoffrey A. Orth, Kevin Holbrook, Michael S. Williams
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Patent number: 8886340Abstract: The present application describes a retention device for anchoring a medical device within the vasculature. The device may include expandable member coupled to an intravascular medical device and proportioned for receipt within a vessel. At least a portion of the expandable member is expandable to radially engage a vessel wall and to thereby retain the medical device within the vessel. The system is suitable for a variety of intravascular devices, including but not limited to ICD's, pacemakers, and intravascular drug delivery systems.Type: GrantFiled: October 20, 2010Date of Patent: November 11, 2014Assignee: Interventional Autonomics CorporationInventors: Michael S. Williams, Terrance Ransbury, Richard A. Glenn, Kevin Holbrook
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Publication number: 20140128750Abstract: A neuromodulation system includes a first therapy element adapted for positioning within a superior vena cava, and a second therapy element adapted for positioning within a pulmonary artery. The first therapy element is carried on a first elongate flexible shaft, and the second therapy element is carried on a second elongate flexible shaft. One of the first and second shafts is slidably received within a lumen of the other of the first and second shafts—so that the second therapy element may be advanced within the body relative to the first therapy element. A stimulator is configured to energize the first therapy element within the first blood vessel to deliver therapy to a first nerve fiber disposed external to the superior vena cava and to energize the second therapy element within the pulmonary artery to deliver sympathetic therapy to a second nerve fiber disposed external to the pulmonary artery.Type: ApplicationFiled: January 9, 2014Publication date: May 8, 2014Applicant: Interventional Autonomics CorporationInventors: Terrance J Ransbury, Richard S Stack, William E Sanders, Stephen C Masson