Abstract: The present invention discloses novel recombinant multivalent non-pathogenic Marek's Disease virus constructs that encode and express both Infectious Laryngotracheitis Virus protein antigens and an Infectious Bursal Disease virus protein antigen, and methods of their use in poultry vaccines.
Type:
Application
Filed:
February 1, 2023
Publication date:
April 18, 2024
Applicant:
Intervet Inc.
Inventors:
Stephanie Cook, Mohamad Morsey, Ian Tarpey, Iwan Verstegen, Paulus Jacobus Antonius Sondermeijer, Paul Vermeij
Abstract: This invention is directed to a pharmaceutical composition for drinking water administration comprising isoxazoline compounds of formula (I) and a polysorbate surfactant and diethylene glycol monoethyl ether (transcutol); and the use of the composition to treat or prevent parasite infestations of animals.
Abstract: The present invention relates to cyclopropylamide compounds that are useful in the treatment of parasitic infestations of fish. The compounds have the formula (I).
Inventors:
James Edward Hunter, Lori Kay Lawler, Tony Kent Trullinger, Martin Joseph Walsh, Harald Schmitt, Anja Regina Heckeroth, Jürgen Lutz, Maria Daniela Fähsing, Hartmut Zoller
Abstract: The present invention pertains to the use of conjugated fumonisin (FUM) in a method to protect an animal against FUM induced mycotoxicosis, in particular to protect against a decrease in average daily weight gain, intestinal damage, liver damage and kidney damage as a result of the ingestion of FUM.
Type:
Application
Filed:
December 21, 2021
Publication date:
April 11, 2024
Applicant:
INTERVET INC.
Inventors:
Sietske Kooijman, Ruud Philip Antoon Maria Segers, Maarten Hendrik Witvliet
Abstract: A method for external fish parasite monitoring in aquaculture, comprising the steps of: submerging a camera (52) in a sea pen containing fish, the camera having a field of view; capturing images of the fish with the camera (52); and identifying external fish parasite on the fish by analyzing the captured images, characterized in that a target region within the field of view of the camera (52) is illuminated from above and below with light of different intensities and/or spectral compositions.
Type:
Application
Filed:
November 13, 2023
Publication date:
March 14, 2024
Applicant:
Intervet Inc.
Inventors:
Russel Howe, Zachary Lizer, James Wallace Sarrett, Peter Jon Abrahamson, Jascha Tucker Little
Abstract: The present invention discloses antibodies to canine PD-I that have specific sequences and a high binding affinity for canine PD-I. The invention also discloses the use of the antibodies of the present invention in the treatment of cancer in dogs.
Type:
Application
Filed:
May 8, 2023
Publication date:
March 14, 2024
Applicant:
Intervet Inc.
Inventors:
Mohamad Morsey, Yuanzheng Zhang, Denise Bartels-Morozov, Jason Erskine, Ian Tarpey
Abstract: A process for the manufacture of semi-plastic pharmaceutical unit doses using a rotary moulding machine and semi-plastic pharmaceutical dosage units obtained by this process.
Abstract: The present invention regards recombinant HVT (rHVT) constructs, useful as multivalent vector vaccine for poultry. The rHVT comprise 4 heterologous genes from poultry pathogens: the VP2 gene from IBDV, the F gene from NDV, and the gD and gI genes from ILTV. The VP2 and F genes are inserted in the Us genome region of the rHVT. The gD-gI genes are inserted in the UL genome region, either between UL44 and UL45, or between UL45 and UL46. The rHVTs proved to be genetically stable in vitro and in vivo, and expressed all inserted genes well enough to induce protective immunity in vaccinated poultry against IBDV, NDV, and ILTV.
Type:
Application
Filed:
December 23, 2021
Publication date:
February 22, 2024
Applicant:
Intervet Inc.
Inventors:
Martijn Alexander Langereis, Iwan Verstegen
Abstract: A system for external fish parasites monitoring in aquaculture, the system comprising: a camera (52) suitable to be submerged in a sea pen suitable for containing comprising fish, the camera being arranged for capturing images of the fish; and an electronic image processing system (86) configured for identifying external fish parasites on the fish by analyzing the captured images, wherein: a ranging detector (54) configured for detecting the presence of fish and measuring a distance from the detector to the fish is mounted adjacent to the camera (52); and an electronic control system (12) is arranged to control a focus of the camera (52) on the basis of the measured distance and to trigger the camera (52) when a fish has been detected within a predetermined distance range.
Type:
Application
Filed:
October 27, 2023
Publication date:
February 22, 2024
Applicant:
Intervet Inc.
Inventors:
Russel Howe, Zachary Lizer, James Wallace Sarrett, Peter Jon Abrahamson, Jascha Tucker Little
Abstract: A Process for the Preparation of N-(bis(4-methoxyphenyl)methyl)-6-oxo-2-(pyridazin-3-yl)-1,6-dihydropyrimidine-5-carboxamide with improved reaction conditions and reduced use of toxic reagents and solvents.
Abstract: The invention relates to a diagnostic use of an African Swine Fever Vims CD2v protein, a method, a device, and a kit for the detection of the presence of ASFV antibodies in a test sample, in particular the use thereof in a DIVA immunoassay.
Abstract: The present invention relates to new anthelmintic compounds. These compounds can for example be used in the treatment of the kind of worm disease caused by helminths such as Dirofilaria, in particular Dirofilaria immitis.
Type:
Application
Filed:
December 10, 2021
Publication date:
February 8, 2024
Applicant:
Intervet Inc.
Inventors:
Michael Berger, Michael Linder, Carolin Schneider, Janina Tänzler, Ulrich Sondern
Abstract: The invention pertains to a vaccine comprising non-live antigen of a poultry pathogen and a mucoadhesive adjuvant, for use in boosting an immune response in a poultry animal directed against the poultry pathogen by administering the vaccine mucosally to the poultry animal. The invention also pertains to a vaccine comprising a liquid pharmaceutically acceptable carrier, a non-live antigen of a poultry pathogen and a mucoadhesive adjuvant, as well as a method of boosting an immune response in a poultry animal, which immune response is directed against a poultry pathogen, by administering a vaccine mucosally to the poultry animal, the vaccine comprising a non-live antigen of the said poultry pathogen and a mucoadhesive adjuvant.
Type:
Application
Filed:
February 7, 2021
Publication date:
February 8, 2024
Applicant:
Intervet Inc.
Inventors:
Willem Pieter Cornelis Pulskens, Paul Vermeij, Theodorus Jansen, Wilhelmus Gerardus Johannes Degen, Carla Christina Schrier
Abstract: The present invention relates to new anthelmintic compounds. These compounds can for example be used in the treatment of the kind of worm disease caused by helminths such as Dirofilaria, in particular Dirofilaria immitis.
Type:
Application
Filed:
December 10, 2021
Publication date:
February 8, 2024
Applicant:
Intervet Inc.
Inventors:
Michael Berger, Michael Linder, Carolin Schneider, Janina Tänzler, Ulrich Sondern
Abstract: Currently, there is no effective vaccination against M. bovis on the market, and treatment options become increasingly limited due to restrictions in the use of, and resistance to antibiotics. This is complicated by results that demonstrate the induction of vaccine-enhanced disease, upon the use of certain M. bovis proteins as a vaccine. Thus, there is an urgent need for an effective and safe M. bovis vaccine. A novel vaccine composition was found that comprises one or more recombinant proteins which (combined) contain one or more epitopes from each of a set of specific M. bovis proteins. Vaccines based on these recombinant proteins were found to be safe, and were effective in protecting ruminants against infection and disease resulting from a severe challenge infection with M. bovis, as was apparent from a strong reduction of lung damage and colonisation of the trachea.
Abstract: The present invention provides a vaccine for canine Lyme disease and methods of making and using the vaccine alone, or in combinations with other protective agents.
Type:
Grant
Filed:
December 3, 2018
Date of Patent:
January 30, 2024
Assignee:
Intervet Inc.
Inventors:
Rhonda LaFleur, Jennifer C. Dant, Mark A. Mogler, Steven M. Callister, Zhichang Xu
Abstract: This invention is directed to a pharmaceutical composition for drinking water administration comprising isoxazoline compounds of formula (I) and a polysorbate surfactant and diethylene glycol monoethyl ether (transcutol); and the use of the composition to treat or prevent parasite infestations of animals.
Abstract: The present invention relates to vaccines against influenza virus infection or disease for targets with pre-existing antibodies against influenza virus HA head domain. The invention regards a recombinant vector expressing a HA stem polypeptide, a vaccine comprising the vector or a host cell with said vector, uses of the vector, the host cell, or the vaccine, and methods for reducing influenza virus infection or disease. The recombinant vector can be a nucleic acid such as a eukaryotic expression plasmid or an RNA, a virus, or a replicon particle (RP). This vaccination allows for the induction of an early- and effective immune-response against Influenza virus induced infection or disease, not hindered by pre-existing anti-HA head domain antibodies.
Type:
Application
Filed:
September 6, 2021
Publication date:
January 25, 2024
Applicant:
Intervet Inc.
Inventors:
Martijn Alexander Langereis, Iwan Verstegen, Maria Alexander Cornelis De Haan
Abstract: The present invention pertains to the use of conjugated aflatoxin (AFB) in a method to protect an animal against AFB induced mycotoxicosis, in particular to protect against a decrease in average daily weight gain, immune suppression, icterus, hemorrhagic enteritis as a result of the ingestion of AFB.
Type:
Application
Filed:
December 21, 2021
Publication date:
January 25, 2024
Applicant:
Intervet Inc.
Inventors:
Maarten Hendrik Witvliet, Ruud Philip Antoon Maria Segers, Mateusz Walczak