Patents Assigned to InterVet, Inc.
  • Publication number: 20210162036
    Abstract: The present invention relates to the use of a diluent for the in-use stabilisation of cells infected with a cell-associated alphaherpesvims. Contrary to the long-standing practice of incorporating a considerable amount of peptone into the diluent for such virus-infected cells, it was found that a reduction of the amount of protein in the diluent improved the in-use stability of alphaherpesvirus-infected cells. Whereby the best stability was even obtained using a protein-free diluent. This effect was especially pronounced for recombinant HVT viruses expressing a heterologous insert. Being protein-free is highly advantageous for the production of the diluent, in respect of costs, safety, and consistency of production.
    Type: Application
    Filed: December 19, 2018
    Publication date: June 3, 2021
    Applicant: Intervet Inc.
    Inventors: Ad DE GROOF, Iwan VERSTEGEN
  • Publication number: 20210161867
    Abstract: An implant for the control of parasites in livestock comprising an isoxazoline compound of Formula (I) or salt or solvate thereof, wherein the implant comprises one or more pellets each of which comprises the isoxaxoline compound and a pharmaceutically acceptable excipient and a method of preventing or treating a parasite infestation using the same.
    Type: Application
    Filed: December 11, 2018
    Publication date: June 3, 2021
    Applicant: Intervet Inc.
    Inventors: Keith Freehauf, Anagha Avinash Bhakay
  • Patent number: 10986817
    Abstract: An animal health monitoring system includes a plurality of animal tag assemblies configured for being disposed on members of an animal population, each of the animal tag assemblies including one or more sensors configured to measure one or more animal characteristics of a member of the animal population. The system includes a concentrator communicatively coupled to the plurality of animal tag assemblies and configured to acquire one or more animal characteristics from the plurality of animal tag assemblies. The system includes a controller communicatively coupled to the concentrator and configured to receive the acquired one or more animal characteristics from the plurality of animal tag assemblies from the concentrator, determine a health state of one or more of the members of the animal population based on the received one or more animal characteristics, and report the determined health state to one or more user devices.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: April 27, 2021
    Assignee: INTERVET INC.
    Inventors: Vishal Singh, Brian Schupbach, Andrew Uden, Aaron Mathankeri, Adam Sonty, Alex Heine, Colton Franco, Paul Hoffmeyer, Jacob Armstrong, Matt Leacock, Spencer Kelle, Perry Howell
  • Publication number: 20210107874
    Abstract: The present invention is directed to a salt of a compound of formula (I), R1 is halogen or methyl; X is methyl, OR2, or SR2; Y1, Y2 is CR3 or N, and one of Y1, Y2 is N and one of Y1, Y2 is CR3; R2 is methyl or ethyl; R3 is hydrogen or methyl, wherein the salt is chosen from the group 10 consisting of malate salt, citrate salt, tartrate salt, oxalate salt, fumarate salt, lactate salt, glucoronate salt, oxoglucoronate salt, ethanesulfonate salt, and succinate salt. The present invention is further related to a pharmaceutical formulation comprising the salt of the invention wherein the base compound is present in an amount of 2-30% (w/v) and having a pH value of at least 3.7 and to methods of treatment using the salt of the invention.
    Type: Application
    Filed: March 30, 2018
    Publication date: April 15, 2021
    Applicant: Intervet Inc.
    Inventors: Michael Berger, Hans Peter Niedermann, Marcus Knell, Anne Lehay, Angelique Duval, Anne-Laure Morer, Susi Alteheld
  • Patent number: 10973759
    Abstract: A process for the manufacture of semi-plastic pharmaceutical unit doses using a rotary moulding machine and semi-plastic pharmaceutical dosage units obtained by this process.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: April 13, 2021
    Assignee: Intervet Inc.
    Inventors: Dominique Kluger, Albin Hauler, Carsten Schmidt, David Schroeckenfuchs, Niki Waldron
  • Patent number: 10954491
    Abstract: The present invention relates to a novel porcine pestivirus, to proteins of the virus and to vaccines based upon the virus and proteins thereof. The invention also relates to DNA fragments comprising a gene of the virus and to DNA vaccines based upon genes of the virus. Furthermore the invention relates to antibodies that are reactive with the novel virus and to diagnostic tests for the detection of the virus or antibodies against the virus.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: March 23, 2021
    Assignee: Intervet Inc.
    Inventors: Ad de Groof, Lars Guelen, Carla Christina Schrier, Martin Deijs, Cornelia Maria van der Hoek
  • Patent number: 10953084
    Abstract: The present invention pertains to a vaccine for use in prophylactically treating an animal against an infection with porcine circovirus type 2 (PCV2) and an infection with PRRS virus, the vaccine comprising in combination non-replicating immunogen of porcine circovirus type 2 and live attenuated PRRS virus, wherein the vaccine additionally comprises albumin.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: March 23, 2021
    Assignee: Intervet Inc.
    Inventors: Melanie Sno, Pieter Van Gelder, Vicky Fachinger, Chen Shu-hui Tan
  • Publication number: 20210077610
    Abstract: The present invention pertains to a vaccine to protect a pig against an infection with Actinobacillus pleuropneumoniae, the vaccine comprising an RTX toxin of Actinobacillus pleuropneumoniae recombinantly expressed by a baculovirus, and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: December 19, 2018
    Publication date: March 18, 2021
    Applicant: Intervet Inc.
    Inventors: Maarten Hendrik Witvliet, Johanna Jacoba Elisabeth Bijlsma
  • Publication number: 20210077729
    Abstract: A device for administering a fluid is provided, with a cylinder (16, 116) which has an open dispensing end (17), a piston (36) which is displaceable between a front and rear end position in the cylinder (16, 116) and is connected to a piston rod (35) that protrudes along a first direction beyond a rear end of the cylinder (16, 116) opposite the open dispensing end (17) and is guided in a receiving block (10), a nonreturn valve (18) closing the open dispensing end (17), and a tensioning device (S) which is connected to the piston rod (35, 135) and is arranged in the receiving block (10), wherein the tensioning device (S), when the piston (36) is in its front end position, can move the piston rod (35, 135) in a tensioning operation along the first direction until the piston (36) is in its rear end position in order thereby to fill the cylinder (16, 116) with the fluid to be administered and in order to pretension the piston rod (35, 135) toward the open dispensing end (17), and wherein the tensioning device (S
    Type: Application
    Filed: March 26, 2019
    Publication date: March 18, 2021
    Applicant: Intervet Inc.
    Inventors: Frank Altermann, Daniel Seeh, Dominic Kamenzin, Manuel Mattes, Robin Sauter, Thomas Schmidt
  • Publication number: 20210068375
    Abstract: The present invention pertains to a method for automatic sea lice monitoring in fish aquaculture, the method comprising submerging a camera (4) in a sea pen (300) comprising fish, using the camera to make an image of at least one of said fish, analysing the image to differentiate between individual sea lice present on the fish and the fish itself and assessing the number of sea lice present on the fish, wherein the camera is attached to a device (1, 10, 100) for guiding the salmon along an imaging track (5), the camera being directed to the track.
    Type: Application
    Filed: November 18, 2020
    Publication date: March 11, 2021
    Applicant: Intervet Inc.
    Inventors: Peter Jans, Evert Gijtenbeek
  • Publication number: 20210069417
    Abstract: A device for administering a fluid is provided, with a cylinder (16, 116) which has an open dispensing end (17), a piston (36) which is displaceable between a front and rear end position in the cylinder (16, 116) and is connected to a piston rod (35) that protrudes along a first direction beyond a rear end of the cylinder (16, 116) opposite the open dispensing end (17) and is guided in a receiving block (10), a nonreturn valve (18) closing the open dispensing end (17), and a tensioning device (S) which is connected to the piston rod (35, 135) and is arranged in the receiving block (10). The tensioning device (S) has a ramp (52) which is rotatable by means of a motor (12) and has a ramp track (53) extending along a helical line, wherein the ramp track (53) ascends from a first plateau along a region of inclination (S1, S2) to a second plateau and descends from the second plateau to the first plateau via a transition flank (46).
    Type: Application
    Filed: March 26, 2019
    Publication date: March 11, 2021
    Applicant: Intervet Inc.
    Inventors: Frank Altermann, Dominic Kamenzin, Thomas Schmidt, Manuel Mattes, Robin Sauter, Daniel Seeh
  • Publication number: 20210061775
    Abstract: This invention relates to methods for controlling parasitic infestations of animals and their environments, and, more particularly, to methods using isoxazolines to control parasites in or on animals or in their environments, as well as treat parasitoses of animals. The isoxazolines include 4-(isoxazolinyl)-benzamides (specifically, substituted 4-(5-(halomethyl)-5-phenyl-isoxazolin-3-yl)-benzamides) and 4-(isoxazolinyl)-benzothioamides (specifically, substituted 4-(5-(halomethyl)-5-phenyl-isoxazolin-3-yl)-benzothioamides). This invention also relates to compositions comprising the isoxazolines for use in such methods, the use of the isoxazolines to make medicaments for use in such methods, and kits comprising the isoxazolines for carrying out such methods. This invention further relates to the use of the isoxazolines as medicaments, particularly medicaments that can be used in the above-referenced method.
    Type: Application
    Filed: September 15, 2020
    Publication date: March 4, 2021
    Applicant: Intervet Inc.
    Inventors: Anja Regina Heckeroth, J├╝rgen Lutz, Christina Mertens, Heike Williams, Hartmut Zoller, Takeshi Mita
  • Publication number: 20210052815
    Abstract: A device for administering a fluid is provided, with a cylinder (16, 116) which has an open dispensing end (17), a piston (36) which is displaceable between a front and rear end position in the cylinder (16, 116) and is connected to a piston rod (35) that protrudes along a first direction beyond a rear end of the cylinder (16, 116) opposite the open dispensing end (17) and is guided in a receiving block (10), a nonreturn valve (18) closing the open dispensing end (17), and a tensioning device (S) which is connected to the piston rod (35, 135) and is arranged in the receiving block (10), wherein the tensioning device (S), when the piston (36) is in its front end position, can move the piston rod (35, 135) in a tensioning operation along the first direction until the piston (36) is in its rear end position in order thereby to fill the cylinder (16, 116) with the fluid to be administered and in order to pretension the piston rod (35, 135) toward the open dispensing end (17), and wherein the tensioning device (S
    Type: Application
    Filed: March 26, 2019
    Publication date: February 25, 2021
    Applicant: Intervet Inc.
    Inventors: Frank Altermann, Dominic Kamenzin, Manuel Mattes, Robin Sauter, Thomas Schmidt, Daniel Seeh
  • Patent number: 10927172
    Abstract: The present invention provides caninized murine anti-human PD-1 antibodies that have specific sequences and a high binding affinity for canine PD-1. The invention also relates to use of these antibodies in the treatment of dogs.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: February 23, 2021
    Assignee: INTERVET INC.
    Inventors: Mohamad Morsey, Yuanzheng Zhang, Denise Bartels-Morozov, Jason Erskine, Ian Tarpey, Leonard Presta
  • Publication number: 20210040223
    Abstract: The present invention discloses antibodies and blocking antibodies to canine IL-4 receptor alpha that have specific sequences and a high binding affinity for canine IL-4 receptor ?. The present invention also discloses the use of the antibodies of the present invention in the treatment of atopic dermatitis in dogs. The present invention further discloses unique epitopes that bind to the antibodies to canine IL-4 receptor alpha.
    Type: Application
    Filed: October 27, 2020
    Publication date: February 11, 2021
    Applicant: Intervet Inc.
    Inventors: Mohamad Morsey, Yuanzheng Zhang
  • Publication number: 20210030862
    Abstract: The present invention pertains to a vaccine comprising an IgM protease antigen of Streptococcus suis, for use in a method for protecting pigs against an infection with Streptococcus suis of serotype 2 and against an infection with Streptococcus suis of serotype 9.
    Type: Application
    Filed: December 14, 2018
    Publication date: February 4, 2021
    Applicant: Intervet Inc.
    Inventor: Antonius Arnoldus Christiaan Jacobs
  • Publication number: 20210023303
    Abstract: A device for administering a fluid is provided, with a cylinder (16, 116) which has an open dispensing end (17), a piston (36) which is displaceable between a front and rear end position in the cylinder (16, 116) and is connected to a piston rod (35) that protrudes along a first direction beyond a rear end of the cylinder (16, 116) opposite the open dispensing end (17) and is guided in a receiving block (10), a nonreturn valve (18) closing the open dispensing end (17), and a tensioning device (S) which is connected to the piston rod (35, 135) and is arranged in the receiving block (10).
    Type: Application
    Filed: March 26, 2019
    Publication date: January 28, 2021
    Applicant: Intervet Inc.
    Inventors: Frank Altermann, Dominic Kamenzin, Manuel Mattes, Robin Sauter, Thomas Schmidt, Daniel Seeh
  • Publication number: 20200405692
    Abstract: The present invention relates to methods of treating demodicosis by administering an isoxazoline compound of formula (I)
    Type: Application
    Filed: September 9, 2020
    Publication date: December 31, 2020
    Applicant: Intervet Inc.
    Inventors: Heike Williams, Anja Regina Heckeroth, Janina Tanzler, Regis Joel Alain Frenais
  • Patent number: 10875847
    Abstract: The instant invention provides compounds of formula I which are selective JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as atopic dermatitis, arthritis, and cancer.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: December 29, 2020
    Assignee: Intervet Inc.
    Inventors: Peter H. Fuller, Jason Brubaker, Jonathan R. Young
  • Publication number: 20200390712
    Abstract: The present invention pertains to a method for producing a medicinal product comprising a biologically active protein comprising the steps of providing an aqueous composition comprising a solvent, the biologically active protein and between 20% w/w and 60% w/w of a non-polymeric sugar, freezing the composition, thereby forming at least one frozen body comprising the solvent in frozen form, putting the frozen body in a drying apparatus while being carried by a support, the support comprising one or more restraining elements that define one or more boundaries of the support, wherein at most 30% of the surface of the body is contiguous with the one or more restraining elements, reducing the pressure in the drying apparatus below atmospheric pressure, providing heat to the body in order to sublimate the frozen solvent of the body and obtain a dried body. The invention also pertains to a product obtainable by this method.
    Type: Application
    Filed: July 1, 2020
    Publication date: December 17, 2020
    Applicant: Intervet Inc.
    Inventors: Kevin O'Connell, Sandhya Buchanan