Patents Assigned to Intervet International B.V.
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Patent number: 8309101Abstract: The present invention relates to live attenuated bacteria of the species Pasteurella multocida, to live attenuated vaccines comprising such live attenuated bacteria, to the use of such bacteria for the manufacture of such vaccines, to methods for the preparation of such vaccines and to diagnostic tests for the detection of such bacteria.Type: GrantFiled: December 21, 2005Date of Patent: November 13, 2012Assignee: Intervet International B.V.Inventors: Yugang Luo, Paul Vermeij, Antonius Arnoldus Christiaan Jacobs
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Patent number: 8277814Abstract: The present invention relates to the fields of veterinary virology and immunology. In particular the invention relates to a novel avian Astrovirus; to antibodies or fragments thereof against the novel virus; to antigenic preparations, proteins, and DNA molecules of the novel avian Astrovirus; to vaccines of the novel virus or its antigenic preparations, protein, or DNA; to methods for the manufacture of such vaccines, and to diagnostic kits.Type: GrantFiled: April 27, 2009Date of Patent: October 2, 2012Assignee: Intervet International B.V.Inventors: Sjaak De Wit, Carla Christina Schrier, Marcel Van de Laar, Iwan Verstegen
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Patent number: 8268813Abstract: This invention is directed generally to zilpaterol enantiomer compositions, and, in particular, to compositions comprising the 6R,7R zilpaterol enantiomer. This invention is also directed to processes for making such compositions; methods for using such compositions to, for example, increase the rate of weight gain, improve feed efficiency, and/or increase carcass leanness in livestock, poultry, and/or fish; and uses of such compositions to make medicaments. This invention is further directed to methods for determining the absolute configurations of zilpaterol enantiomers.Type: GrantFiled: July 10, 2007Date of Patent: September 18, 2012Assignee: Intervet International B.V.Inventors: Christian Miculka, Thorsten Meyer, Christopher Kern, Serge Francois Droux
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Patent number: 8263753Abstract: This invention relates to a method for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, inter alia, may be used to make macrolides. This invention also relates to solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms.Type: GrantFiled: July 30, 2010Date of Patent: September 11, 2012Assignee: Intervet International B.V.Inventors: Monika Brink, Hans P. Niedermann, Tanja Schweisel, Stephan Veit, Kerstin Fleischhauer, Ralf Warrass, Heinz-Jorg Wennesheimer
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Patent number: 8252292Abstract: The present invention discloses a vaccine that provides protection to turkeys from coccidiosis, and methods of making and using the vaccine alone, or in combinations with other protective agents. In addition, the present invention discloses PCR primer sets that are useful in identifying the species of Eimeria in a biological sample.Type: GrantFiled: November 11, 2009Date of Patent: August 28, 2012Assignees: Intervet International B.V., Intervet Inc.Inventors: Steve Hewart Fitz-Coy, Gamini Saman Kumara Withanage, Alexandria Louise McGowan, Stephanie M. Cook
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Publication number: 20120208779Abstract: Described are methods for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, inter alia, may be used to make macrolides. Also described are solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms.Type: ApplicationFiled: February 22, 2012Publication date: August 16, 2012Applicant: Intervet International B.V.Inventors: Fritz Blatter, Timo Rager, Ralf Warras
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Patent number: 8236805Abstract: Compounds of Formula (I): or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.Type: GrantFiled: September 22, 2009Date of Patent: August 7, 2012Assignees: Intervet Inc., Intervet International B.V.Inventors: Eric J. Gilbert, Michael W. Miller, Jack D. Scott, Andrew W. Stamford, William J. Greenlee, Jay Weinstein
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Patent number: 8227429Abstract: This invention relates to a method for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, inter alia, may be used to make macrolides. This invention also relates to solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms.Type: GrantFiled: July 26, 2007Date of Patent: July 24, 2012Assignee: Intervet International B.V.Inventors: Ralf Warrass, Fritz Blatter, Meinrad Brenner, Guixan Hu, Tamo Rager
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Publication number: 20120122808Abstract: Described are methods for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, among other uses, may be used to make macrolides. Also described are solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms.Type: ApplicationFiled: January 26, 2012Publication date: May 17, 2012Applicant: INTERVET INTERNATIONAL B.V.Inventors: Ralf Warrass, Fritz Blatter, Meinrad Brenner, Guixan Hu, Timo Rager
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Patent number: 8178103Abstract: This invention relates to two attenuated strains of porcine reproductive and respiratory syndrome virus (PRRSV) and immunogenic compositions comprising one or more strains of attenuated porcine reproductive and respiratory syndrome virus (PRRSV).Type: GrantFiled: November 9, 2005Date of Patent: May 15, 2012Assignee: Intervet International B.V.Inventor: Richard A. Hesse
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Patent number: 8156755Abstract: The invention relates to a refrigerator for storing vials containing a (bio)pharmaceutical substance, in particular vaccines for animals, comprising a cabinet having an internal space for accommodating the vials arranged in columns, a cooling element for cooling the internal space and at least one door or dispenser for removing vials from the internal space. A plurality of guides located inside the space and adapted to slidingly accommodate columns of the vials. The invention further relates to a cartridge suitable for use in the said refrigerator.Type: GrantFiled: June 3, 2005Date of Patent: April 17, 2012Assignee: Intervet International B.V.Inventors: Stephen Murray, Gaynor Hillier, Philip Nigel Bordet-Stead, Tanja Langgner, David Helps
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Patent number: 8133712Abstract: Embodiments of the present invention provide an inactivated chimeric virus and immunogenic compositions for the treatment or prevention of infection with West Nile virus. Further, other embodiments of the present invention relate to methods of preventing and treating West Nile virus infection with the inactivated chimera or immunogenic composition.Type: GrantFiled: May 12, 2011Date of Patent: March 13, 2012Assignee: Intervet International B.V.Inventors: Frank J. Sterner, Daniel Ghislena Emiel Goovaerts, Melissa Anne Lum, Mark William Mellencamp
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Patent number: 8114977Abstract: Embodiments of the present invention generally relate to proteins derived from white spot syndrome virus, nucleic acid sequences encoding them, and their use in the manufacture of a vaccine for prophylaxis and/or treatment of white spot syndrome in crustaceans.Type: GrantFiled: June 18, 2010Date of Patent: February 14, 2012Assignee: Intervet International B.V.Inventors: Maria Cornelia Wilhelmina Van Hulten, Justinus Maria Vlak
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Patent number: 8084040Abstract: The present invention relates to the use of live attenuated bacteria for the manufacture of a vaccine for submucosal administration.Type: GrantFiled: December 1, 2010Date of Patent: December 27, 2011Assignee: Intervet International B.V.Inventors: Antonius Arnoldus Christiaan Jacobs, Daniel G. E. Goovaerts
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Publication number: 20110311586Abstract: The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of the present invention. The subject invention also pertains to compositions and methods for identifying a virus of the invention and diagnosing infection of an animal with a virus of the invention.Type: ApplicationFiled: April 19, 2011Publication date: December 22, 2011Applicants: University of Florida Research Foundation, Inc., Intervet International B.V., The Govt. of the U.S.A. as represented by The Secretary of the Dept. of Health & Human Services, Cornell Research Foundation, Inc.Inventors: Patti C. Crawford, Paul J. Gibbs, Edward J. Dubovi, Ruben Omar Donis, Jacqueline Katz, Alexander I. Klimov, Nallakannu P. Lakshmanan, Melissa Anne Lum, Daniel Ghislena Emiel Goovaerts, Mark William Mellencamp, William L. Castleman, Nancy J. Cox
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Patent number: 8071108Abstract: The present invention comprises new pestivirus mutants, characterized in that the mutants are based on a cp strain of the virus wherein part of the gene sequence encoding the Npro region is deleted, except that the deleted part does not encompass the coding sequence for the N-terminal twelve amino acids of the Npro protein. Preferably the pestivirus is the Bovine Viral Diarrhea Virus (BVDV). It was found that a mutant according to the invention is a safe and efficient vaccine candidate.Type: GrantFiled: September 20, 2007Date of Patent: December 6, 2011Assignee: Intervet International B.V.Inventors: Martin Beer, Ilona Reimann, Patricia Koenig
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Publication number: 20110288141Abstract: The present invention provides formulations and methods useful in eradicating ectoparasites on a domestic animal, decreasing the number of ectoparasites on a domestic animal, and/or preventing ectoparasite infestation on a domestic animal, using a local topical formulation comprising fiproniland a veterinarily acceptable carrier.Type: ApplicationFiled: August 29, 2008Publication date: November 24, 2011Applicant: INTERVET INC. AND INTERVET INTERNATIONAL B.V.Inventors: Keith A. Freehauf, Chen-Chao Wang, Peter Andrew O'neill
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Patent number: 8048429Abstract: Embodiments of the present invention generally provide an inactivated chimeric virus vaccine and/or immunogenic composition for the treatment or prevention of viral infection. Further, various other embodiments of the present invention generally relate to methods of preventing and treating virus infection in such animals with the inactivated vaccine and/or immunogenic composition. Other embodiments comprise methods of preparing a vaccine or immunogenic composition for the treatment or prevention of viral infection in such animals.Type: GrantFiled: June 23, 2006Date of Patent: November 1, 2011Assignee: Intervet International B.V.Inventors: Frank Jay Sterner, Daniel Ghislena Emiel Goovaerts, Melissa Anne Lum, Mark William Mellencamp
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Patent number: 8025884Abstract: The present invention relates i.a. to nucleic acids encoding novel Lawsonia intracellularis proteins. It furthermore relates to DNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Also it relates to host cells comprising such nucleic acids, DNA fragments, recombinant DNA molecules and live recombinant carriers. Moreover, the invention relates to proteins encoded by these nucleotide sequences and to their use for the manufacturing of vaccines. The invention also relates to vaccines for combating Lawsonia intracellularis infections and methods for the preparation thereof. Finally the invention relates to diagnostic tests for the detection of Lawsonia intracellularis antigens and of antibodies against Lawsonia intracellularis.Type: GrantFiled: January 18, 2005Date of Patent: September 27, 2011Assignee: Intervet International B.V.Inventor: Paul Vermeij
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Patent number: 8021670Abstract: The present invention relates to the use of an immunogenic dose of immunogenic material of Mycoplasma hyopneumoniae and an immunogenic dose of live attenuated PRRS virus for the manufacture of a vaccine, and to a vaccine kit comprising such a vaccine.Type: GrantFiled: April 6, 2007Date of Patent: September 20, 2011Assignee: Intervet International B.V.Inventors: Christa Sibilla Drexler, Maarten Witvliet