Patents Assigned to IntraBiotics
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Patent number: 6653442Abstract: Peptide-based compounds containing four invariant cysteine residues which have been optionally oxidized to contain two intramolecular disulfide bonds, or modified forms where the cysteines are replaced are useful as preservatives and in preventing, treating, or ameliorating viral or microbial infection in animals and plants, and in inactivating endotoxin.Type: GrantFiled: August 30, 1999Date of Patent: November 25, 2003Assignee: IntraBiotics Pharmaceuticals, Inc.Inventors: Conway C. Chang, Chee L. Gu, Jie Chen, Deborah A. Steinberg, Robert I. Lehrer, Sylvia S. L. Harwig, Vladimir N. Kokryakov
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Publication number: 20020147301Abstract: The present invention provides a new class of broad-spectrum antimicrobial peptides effective against a wide variety of microbes, including bacteria, viruses, retroviruses, fungi, yeast and protozoa.Type: ApplicationFiled: May 24, 2001Publication date: October 10, 2002Applicant: IntraBiotics Pharmaceuticals, Inc.Inventors: Robert I. Lehrer, Sylvia S.L. Harwig, Conway C. Chang, Chee L. Gu
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Patent number: 6307016Abstract: The present invention provides a new class of broad-spectrum antimicrobial peptides effective against a wide variety of microbes, including bacteria, viruses, retroviruses, fungi, yeast and protozoa.Type: GrantFiled: August 3, 1998Date of Patent: October 23, 2001Assignee: IntraBiotics Pharmaceuticals, Inc.Inventors: Robert I. Lehrer, Sylvia S. L. Harwig, Conway C. Chang, Chee L. Gu
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Patent number: 6043220Abstract: The invention is directed to antimicrobial peptides related to naturally-occurring protegrin peptides, and methods of using the peptides in a variety of contexts, including the treatment or prevention of infections, and diseases related thereto.Type: GrantFiled: December 3, 1997Date of Patent: March 28, 2000Assignee: IntraBiotics Pharmaceuticals, Inc.Inventors: Conway C. Chang, Jie Chen, Robert I. Lehrer, Peggy A. Radel
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Patent number: 6025326Abstract: The present invention provides methods and compositions suitable for treating oral mucositis in animals, including humans, with antimicrobial peptides such as protegrin peptides.Type: GrantFiled: November 21, 1996Date of Patent: February 15, 2000Assignee: IntraBiotics Pharmaceuticals, Inc.Inventors: Deborah A. Steinberg, De Hwa Chao, David J. Loury, Roger Cherng Fu, Chee Liang Gu, Conway C. Chang, John C. Fiddes
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Patent number: 5994306Abstract: The invention is directed to antimicrobial peptides related to naturally-occurring protegrin peptides, and methods of using the peptides in a variety of contexts, including the treatment or prevention of infections.Type: GrantFiled: November 21, 1996Date of Patent: November 30, 1999Assignee: IntraBiotics Pharmaceuticals, Inc.Inventors: Conway C. Chang, Chee Liang Gu, Jie Chen, Deborah A. Steinberg, Robert I. Lehrer, Sylvia S.L. Harwig, deceased
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Patent number: 5916872Abstract: The present invention provides cyclic peptides having broad spectrum antimicrobial activity. The peptides exhibit improved efficacy, bioavailability and/or serum half-life as compared with non-cyclized analogues.Type: GrantFiled: July 24, 1996Date of Patent: June 29, 1999Assignee: IntraBiotics Pharmaceuticals, Inc.Inventors: Conway Chang, Leo Gu, Jie Chen
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Patent number: 5693486Abstract: Peptide-based compounds containing four invariant cysteine residues which have been optionally oxidized to contain two intramolecular disulfide bonds, or modified forms where the cysteines are replaced, are useful as preservatives and in preventing, treating, or ameliorating viral or microbial infection in animals and plants, and in inactivating endotoxin. These compounds, in one embodiment, are of the formula:A.sub.1 -A.sub.2 -A.sub.3 -A.sub.4 -A.sub.5 -C-A.sub.7 -C-A.sub.9 -A.sub.10 -A.sub.11 -A.sub.12 -C-A.sub.14 -C-A.sub.16 -(A.sub.17 -A.sub.18)(1)(SEQ ID NO:1)and the N-terminal acylated and/or C-terminal amidated or esterified forms thereof, either in optionally --SH stabilized linear or in cystine-bridged formwherein A.sub.1, A.sub.9, A.sub.10, and A.sub.11 are basic amino acids;A.sub.2 and A.sub.3 are small amino acids;A.sub.5, A.sub.7, A.sub.12, A.sub.14 and A.sub.16 are hydrophobic amino acids; andA.sub.4 is a basic or a small amino acid;A.sub.Type: GrantFiled: January 13, 1994Date of Patent: December 2, 1997Assignee: IntraBioticsInventors: Robert I. Lehrer, Vladimir N. Kokryakov, Sylvia S. L. Harwig
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Patent number: RE38828Abstract: The present invention provides a new class of broad-spectrum antimicrobial peptides effective against a wide variety of microbes, including bacteria, viruses, retroviruses, fungi, yeast and protozoa.Type: GrantFiled: September 24, 2002Date of Patent: October 11, 2005Assignee: IntraBiotics Pharmaceuticals, Inc.Inventors: Robert I. Lehrer, Sylvia S. L. Harwig, Conway C. Chang, Chee L. Gu