Patents Assigned to Intrex Research Corporation
  • Prodrugs for the improved delivery of halogen-containing glucocorticosteroids
    Patent number: 4279900
    Abstract: Novel 3,2'-spiro(1',3'-thiazolidine) compounds which are transient prodrug forms of known 6- and/or 9-haloglucocorticosteroids are described. The subject prodrugs provide improved delivery of the prior art steroids for therapeutic purposes, particularly in alleviating inflammation, and can be prepared by known methods, for example, by reacting the corresponding 3-keto steroids with a thiazolidine forming reagent such as an L-cysteine alkyl ester.
    Type: Grant
    Filed: July 27, 1979
    Date of Patent: July 21, 1981
    Assignee: Intrex Research Corporation
    Inventors: Nicholas S. Bodor, Kenneth B. Sloan