Abstract: Catheter assemblies include a stabilization mechanism disposed at a distal end of the catheter assembly for stabilizing the catheter assembly within a subintimal space. The stabilization mechanism includes a self-expanding support structure that is slidably positionable within an inflatable balloon. The catheter assemblies include an outer shaft which has the balloon at a distal end thereof and an inner shaft which has the support structure mounted on a distal end thereof. The inner shaft is slidably disposed within a lumen of the outer shaft and has a first configuration in which the support structure is held in a compressed state within the outer shaft and a second configuration in which the support structure is permitted to return to an expanded state within the inflatable balloon. In the expanded state, the stabilization mechanism has a flattened laterally-extending profile.

Abstract: A catheter having a distal balloon and a deformable guidewire shaft of the catheter. The deformable guidewire shaft is adjacent to and external to the balloon. Inflation of the balloon bends the deformable guidewire shaft in order to orient or deflect a distal tip of the deformable guidewire shaft in a desired direction to guide and direct a guidewire extending through the deformable guidewire shaft towards a specific endovascular region. For example, it may be desired to orient the distal tip of the guidewire shaft towards a target vessel of a bifurcation or the balloon catheter may be used to bypass a Chronic Total Occlusion (CTO).

Abstract: An apparatus having a distal end that may be selectively bent in situ. The apparatus has a curved configuration and a substantially straightened configuration. First and second tubular components of the apparatus each include a distal portion that is at an acute angle with respect to a longitudinal axis of the apparatus. The second tubular component is rotatably disposed within the first tubular component. In the curved configuration, the distal portions of the first and second tubular components are positioned to extend at substantially the same acute angle with respect to the longitudinal axis of the apparatus. In the substantially straightened configuration, the distal portions of the first and second tubular components are positioned such that the curvatures thereof counterbalance each other. The first and second tubular components may be used in an occlusion bypassing apparatus for re-entering the true lumen of a vessel after subintimally bypassing an occlusion.

Abstract: A blood clot removal device (1), comprising a capture member (2) having a tubular body (3) of prevailing longitudinal extension and provided with a lumen (10) extending longitudinally in said tubular body (3), at least one proximal portion (4), at least one distal portion (5), an apical end (6) of said distal portion (5), and a tip (7); said at least one distal portion (5) of said capture member (2) having at least one helical length (8) provided, with coils (16) wrapped in a helical manner forming a pitch (p) therebetween in the longitudinal direction and adapted to the capture of blood clots (9); an inner cable (11) received in said longitudinal lumen (10) of said tubular body (3) so as to remain within said tubular body (3) helical length (8), said inner cable (11) comprising a proximal length (12) having a proximal maneuvering end (13) and a distal length (14) provided with a tip (15); wherein said tip (15) of said inner cable (11) is secured to said apical end (6) of said capture member (2) tubular body

Abstract: A catheter for subintimally bypassing an occlusion in a vessel includes a catheter shaft including a guidewire lumen disposed therethrough and having a shaft longitudinal axis, at least two balloons coupled to an exterior of the catheter shaft such that longitudinal axes of the balloons are in a common plane with the shaft longitudinal axis when uninflated and with no external forces on the catheter. The balloons are configured such that when the catheter is disposed in the subintima of a vessel and the balloons are inflated, a tip of the catheter shaft is oriented towards a true lumen of the vessel distal of the occlusion.

Abstract: A catheter for use with a subintimal reentry guidewire includes a proximal portion having a proximal guidewire lumen and a proximal inflation lumen, a distal portion having a distal guidewire lumen and a distal inflation lumen, and an intermediate portion disposed between the proximal portion and the distal portion and having an intermediate inflation lumen in fluid communication with the proximal and distal inflation lumens. The intermediate portion is devoid of a guidewire lumen. A blocking mechanism disposed in the distal portion of the catheter is transformable from a non-blocking configuration in which a guidewire is free to translate through the distal guidewire lumen and a blocking configuration in which a guidewire disposed in the distal guidewire lumen is prevented from translating through the distal guidewire lumen.

Abstract: Occlusion bypassing apparatuses are disclosed for re-entering the true lumen of a vessel after subintimally bypassing an occlusion in a vessel. The occlusion bypassing apparatuses include a shaft component and a needle component slidably disposed within the shaft component and having an angled configuration when deployed. In embodiments hereof, the needle component has an angled distal tip segment that may be utilized to selectively bend a flexible distal portion of the shaft component in order to extend the flexible distal portion towards the true lumen of the vessel. The needle component is distally advanced relative to the shaft component to pierce through the intima of the vessel and thereafter enter the true lumen.

Abstract: Occlusion bypassing apparatuses are disclosed for re-entering the true lumen of a vessel after subintimally bypassing an occlusion in a vessel. The occlusion bypassing apparatuses include a shaft component and a needle component slidably disposed within the shaft component and having an angled configuration when deployed. In embodiments hereof, the needle component has an angled distal tip segment that may be utilized to selectively bend a flexible distal portion of the shaft component in order to extend the flexible distal portion towards the true lumen of the vessel. The needle component is distally advanced relative to the shaft component to pierce through the intima of the vessel and thereafter enter the true lumen.

Abstract: Balloon angioplasty catheters having cutting or scoring members that are moveable in at least one direction between a stowed position (away from the angioplasty balloon) and an operative position (on the angioplasty balloon). A balloon catheter of the present invention alternately useable to perform balloon dilation of a body lumen with and without concurrent cutting or scoring.

Abstract: The present invention relates to a balloon (1) for treating stenosis and the method for obtaining this balloon. The method comprises the steps of: bringing the balloon in the deployed configuration; placing a plurality of stylets (17) that are arranged in the axial direction along the outer wall (10) of the balloon; pushing the stylets towards the balloon core (11) in the radial direction such as to form a plurality of laps (12); laying the laps about the core in the tangential direction such as to lay each lap on an adjacent stylet; removing the stylets such as to form a plurality of cavities (13) comprised between each lap and the balloon core; filling the cavities with the drug.

Abstract: Catheter devices and methods useable for directing a guidewire from a subintimal position within the wall of an artery into the true lumen of that artery or other applications wherein it is desired to direct a guidewire or other elongate device from one location to another location within a subject's body.

Abstract: A catheter having a distal balloon and a deformable guidewire shaft of the catheter. The deformable guidewire shaft is adjacent to and external to the balloon. Inflation of the balloon bends the deformable guidewire shaft in order to orient or deflect a distal tip of the deformable guidewire shaft in a desired direction to guide and direct a guidewire extending through the deformable guidewire shaft towards a specific endovascular region. For example, it may be desired to orient the distal tip of the guidewire shaft towards a target vessel of a bifurcation or the balloon catheter may be used to bypass a Chronic Total Occlusion (CTO).

Abstract: A catheter having a distal balloon and a deformable guidewire shaft of the catheter. The deformable guidewire shaft is adjacent to and external to the balloon. Inflation of the balloon bends the deformable guidewire shaft in order to orient or deflect a distal tip of the deformable guidewire shaft in a desired direction to guide and direct a guidewire extending through the deformable guidewire shaft towards a specific endovascular region. For example, it may be desired to orient the distal tip of the guidewire shaft towards a target vessel of a bifurcation or the balloon catheter may be used to bypass a Chronic Total Occlusion (CTO).

Abstract: The present invention relates to a catheter suitable for conducting and positioning a medical device in an organic cavity comprising at least one side branch, such as a blood vessel, which comprises a tubular body, having a central lumen having a cross-section suitable for the passage of the medical device and a mandrel slidable in the central lumen and distally a flexible end portion. On the outer surface of the mandrel there is a longitudinal groove defining, with the inner wall of the tubular body, a passage suitable for receiving a first guide wire in a sliding manner. In addition, in the mandrel there is an inner lumen suitable for housing a second guide wire in a sliding manner. The present invention further relates to a catheter assembly comprising the aforesaid catheter and a method of use the same.

Abstract: Catheters, systems, and methods for achieving renal neuromodulation by intravascular access. A catheter has an energy delivery device positionable in a renal blood vessel and being transformable between a radially constrained low-profile state and a self-expanded deployed state. The energy delivery device includes a first electrode array spaced longitudinally from and flexibly connected to a second electrode array, the arrays being sized and shaped so that the electrode regions contact an interior wall of the renal blood vessel when the energy delivery device is in the deployed state. The electrode regions are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers.

Abstract: The present invention relates to a catheter suitable for conducting and positioning a medical device in an organic cavity comprising at least one side branch, such as a blood vessel, which comprises a tubular body, having a central lumen having a cross-section suitable for the passage of the medical device and a mandrel slidable in the central lumen and distally a flexible end portion. On the outer surface of the mandrel there is a longitudinal groove defining, with the inner wall of the tubular body, a passage suitable for receiving a first guide wire in a sliding manner. In addition, in the mandrel there is an inner lumen suitable for housing a second guide wire in a sliding manner. The present invention further relates to a catheter assembly comprising the aforesaid catheter and a method of use the same.