Abstract: The present invention relates to antibodies, or antigen-binding fragments thereof, directed against human leukocyte antigen-G (HLA-G) protein and raised against an immunogenic peptide derived from the ?3 domain of HLA-G protein. The invention further relates to the immunogenic peptide, and methods for producing said anti-HLA-G specific antibodies.
Type:
Grant
Filed:
April 25, 2022
Date of Patent:
April 25, 2023
Assignee:
Invectys SA
Inventors:
Pierre Langlade Demoyen, Thierry Huet, Julien Caumartin, Maria Loustau, Maria Wehbe
Abstract: The present invention relates to chimeric antigen receptors (CAR) against multiple but not all human leukocyte antigen (HLA-G) isoforms. More specifically, the invention concerns CARs that are specific for HLA-G ?2M-free or ?2M-associated immunosuppressive isoforms respectively.
Type:
Grant
Filed:
May 9, 2022
Date of Patent:
November 22, 2022
Assignee:
Invectys SA
Inventors:
Maria Loustau, François Anna, Pierre Langlade Demoyen, Julien Caumartin
Abstract: The present invention relates to chimeric antigen receptors (CAR) against multiple but not all human leukocyte antigen (HLA-G) isoforms. More specifically, the invention concerns CARs that are specific for HLA-G ?2M-free or ?2M-associated immunosuppressive isoforms respectively.
Type:
Grant
Filed:
September 10, 2021
Date of Patent:
May 10, 2022
Assignee:
Invectys SA
Inventors:
Maria Loustau, François Anna, Pierre Langlade Demoyen, Julien Caumartin
Abstract: The present invention relates to antibodies, or antigen-binding fragments thereof, directed against human leukocyte antigen-G (HLA-G) protein and raised against an immunogenic peptide derived from the ?3 domain of HLA-G protein. The invention further relates to the immunogenic peptide, and methods for producing said anti-HLA-G specific antibodies.
Type:
Grant
Filed:
September 3, 2021
Date of Patent:
April 26, 2022
Assignee:
Invectys SA
Inventors:
Pierre Langlade Demoyen, Thierry Huet, Julien Caumartin, Maria Loustau, Maria Wehbe
Abstract: The present invention relates to chimeric antigen receptors (CAR) against multiple but not all human leukocyte antigen (HLA-G) isoforms. More specifically, the invention concerns CARs that are specific for HLA-G ?2M-free or ?2M-associated immunosuppressive isoforms respectively.
Type:
Grant
Filed:
October 22, 2020
Date of Patent:
September 14, 2021
Assignee:
Invectys SA
Inventors:
Maria Loustau, François Anna, Pierre Langlade Demoyen, Julien Caumartin
Abstract: The present invention relates to antibodies, or antigen-binding fragments thereof, directed against human leukocyte antigen-G (HLA-G) protein and raised against an immunogenic peptide derived from the ?3 domain of HLA-G protein. The invention further relates to the immunogenic peptide, and methods for producing said anti-HLA-G specific antibodies.
Type:
Grant
Filed:
October 26, 2020
Date of Patent:
September 7, 2021
Assignee:
Invectys SA
Inventors:
Pierre Langlade Demoyen, Thierry Huet, Julien Caumartin, Maria Loustau, Maria Wehbe