Abstract: An endoscopic clip device for closure of a mucosal defect or transmural perforation in a gastrointestinal wall may include a sleeve and a clip disposed at least partially within and coupled to the sleeve. The clip may be configured for reversibly moving between an open configuration for positioning relative to the wall and a closed configuration for closing the defect or perforation. The clip may include a first clip arm configured for engaging the mucosal and submucosal layers of the wall and including a first needle extending to a distal end of the first clip arm and configured for advancing through the mucosal layer and into at least the submucosal layer, and a second clip arm disposed opposite the first clip arm and configured for engaging the mucosal layer. The device may be configured for advancing through an operative channel of an endoscope or overtube having a tortuous shape.

Abstract: A system and method for gaining access to an internal bodily structure, such as the ampullae. The system includes an elongate catheter having a lumen extending there through. An elongate wire including a distal coil is movably extendable from the distal end of the catheter and is configured to engage the inner surface of the bodily structure. Proximal movement of the elongate wire flattens the inner surface of the bodily structure and aligns the passageway thereof with the longitudinal axis of the catheter.

Abstract: A method and apparatus for mucosal biopsy including a stationary base clevis component, upon which an open frame jaw is actuated rotationally to engage tissue and retract samples. A rack and pinion mechanism drives the jaw motion, which can be controlled axially by the physician. A metal retriever component captures tissue from the open frame jaw, and advances the samples proximally into the collection chamber, where they are maintained as the retriever is returned to its most distal position. Furthermore, the open frame design employs a reliable and compact means for actuation that can be decoupled from sample transfer and storage functions.