Patents Assigned to Inventiva
  • NON-INVASIVE MONITORING OF LIVER DISEASE TREATMENT
    Publication number: 20240408069
    Abstract: The present disclosure relates to a method for assessing the effectiveness of a treatment with lanifibranor in a patient with a liver disease, the method comprising: a) in vitro measuring levels of a combination of biomarkers consisting of adiponectin, ferritin, MMP9 and transferrin in a biological sample from the patient; and b) assessing the effectiveness of the treatment with lanifibranor as a function of the levels measured in step a).
    Type: Application
    Filed: June 6, 2024
    Publication date: December 12, 2024
    Applicant: INVENTIVA
    Inventors: Pierre BROQUA, Philippe HUOT-MARCHAND, Lucile DZEN, Jérôme BOURSIER, Marine ROUX, Hugo HERVÉ
  • NON-INVASIVE MONITORING OF LIVER DISEASE TREATMENT
    Publication number: 20240410904
    Abstract: The present disclosure relates to a method of assessing the effectiveness of a treatment with lanifibranor in a patient with a liver disease, the method comprising: a) in vitro measuring levels of a combination of biomarkers consisting of CK18M65, hyaluronic acid, fructosamine and ALT in a biological sample from the patient; b) assessing the effectiveness of the treatment with lanifibranor as a function of the levels measured in step a).
    Type: Application
    Filed: June 6, 2024
    Publication date: December 12, 2024
    Applicant: INVENTIVA
    Inventors: Pierre BROQUA, Philippe HUOT-MARCHAND, Lucile DZEN, Jérôme BOURSIER, Marine ROUX, Hugo HERVÉ
  • Inhibitors of the YAP/TAZ-TEAD interaction and their use in the treatment of cancer
    Patent number: 11999758
    Abstract: The invention relates to compounds of formula (I): wherein R1, R2, R3, R4, R5 and are as defined in the description.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: June 4, 2024
    Assignee: INVENTIVA
    Inventors: Martine Barth, Sylvie Contal, Jean-Louis Junien, Christine Massardier, Christian Montalbetti, Anne Soude
  • Method of treatment of cirrhosis
    Patent number: 11504380
    Abstract: The invention relates to a method of treating cirrhosis which comprises administering to a subject in need thereof lanifibranor or a deuterated derivative thereof.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: November 22, 2022
    Assignee: INVENTIVA
    Inventors: Guillaume Wettstein, Pierre Broqua, Jean-Louis Junien
  • Compounds as inhibitors of the YAP/TAZ-TEAD interaction and their use in the treatment of malignant mesothelioma
    Patent number: 10414739
    Abstract: The invention relates to compounds of formula (I): wherein R1, R2, R3, R4, R5 and R6 are as defined in the description. The compounds of formula (I) are inhibitors of the YAP/TAZ-TEAD interaction.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: September 17, 2019
    Assignee: INVENTIVA
    Inventors: Martine Barth, Sylvie Contal, Christian Montalbetti, Luc Spitzer
  • PPAR compounds for use in the treatment of fibrotic diseases
    Patent number: 10383858
    Abstract: The invention relates to the use of a pan-PPAR agonist, or of a pharmaceutical composition containing said agonist, for the treatment of a fibrotic condition.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: August 20, 2019
    Assignee: INVENTIVA
    Inventors: Irena Konstantinova, Jean-Michel Luccarini, Jean-Louis Junien, Pierre Broqua
  • Method of treatment of a mucopolysaccharidosis
    Patent number: 10092540
    Abstract: The present invention relates to the use of 4-methyl-2-oxo-2H-1-benzopyran-7-yl-5-thio-?-D-xylopyranoside in the treatment of a mucopolysaccharidosis such as type I mucopolysaccharidosis.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: October 9, 2018
    Assignee: INVENTIVA
    Inventors: Philippe Masson, Jean-Louis Junien, Mireille Tallandier
  • PPAR compounds for use in the treatment of fibrotic diseases
    Patent number: 10052311
    Abstract: The invention relates to the use of a pan-PPAR agonist, or of a pharmaceutical composition containing said agonist, for the treatment of a fibrotic condition.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: August 21, 2018
    Assignee: INVENTIVA
    Inventors: Irena Konstantinova, Jean-Michel Luccarini, Jean-Louis Junien, Pierre Broqua
  • Use of Odiparcil in the treatment of a mucopolysaccharidosis
    Patent number: 9561246
    Abstract: The present invention relates to a method of treatment of a mucopolysaccharidosis with 4-methyl-2-oxo-2H-1-benzopyran-7-yl-5-thio-?-D-xylopyranoside.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: February 7, 2017
    Assignee: Inventiva
    Inventors: Philippe Masson, Jean-Louis Junien