Patents Assigned to Inventprise, Inc.
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Publication number: 20250186569Abstract: This invention is directed to immunogenic composition, conjugates, virus-lie particles (VLP) compositions, vaccines and methods directed to the treatment and/or prevent of infection by Human Papillomavirus.Type: ApplicationFiled: February 14, 2025Publication date: June 12, 2025Applicant: Inventprise, Inc.Inventors: Subhash V. Kapre, Anup K. Datta
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Publication number: 20250177507Abstract: The invention is directed to compositions and methods for the prevention and treatment of infections where the causative agent is a Klebsiella microorganism. In particular, the invention is directed to multivalent immunogenic compositions and vaccines containing multiple different serotypes of Klebsiella capsular polysaccharides and/or subcapsular polysaccharides that are prevalent in low- and middle-income countries where the burden of disease is high.Type: ApplicationFiled: December 4, 2024Publication date: June 5, 2025Applicant: Inventprise, Inc.Inventors: Subhash V. Kapre, Manoj Kumar
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Patent number: 12251438Abstract: The disclosure describes compositions containing PEGylated compounds using linkers, bivalent polysaccharide covalent PEG compounds, and methods of bivalent polysaccharide-PEG compounds in the development of multivalent vaccines. PEGylated conjugation of capsular polysaccharides to carrier proteins is carried out using homo-bifunctional and/or hetero-bifunctional linkers of specific lengths. Incorporation of bifunctional PEG linkers induces higher titers of functional antibodies with high avidity, eliciting higher immunologic memory, and reduced carrier protein effect. This provides immunochemically cross-reactive capsular polysaccharides wherein one or more cross-reactive capsular polysaccharides are covalently PEG compounded sequentially or concurrently to carrier protein using bifunctional linkers bearing the same or different functional groups.Type: GrantFiled: July 4, 2022Date of Patent: March 18, 2025Assignee: Inventprise, Inc.Inventors: Subhash V. Kapre, Anup K. Datta
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Patent number: 12239697Abstract: This invention is directed to immunogenic composition, conjugates, virus-like particles (VLP) compositions, vaccines and methods directed to the treatment and/or prevent of infection by Human Papillomavirus.Type: GrantFiled: July 5, 2022Date of Patent: March 4, 2025Assignee: Inventprise, Inc.Inventors: Subhash V. Kapre, Anup K. Datta
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Publication number: 20250059502Abstract: The invention is directed to tools, compositions, and methods for the cultivation of microorganisms in culture media that is devoid of animal-derived materials such as blood, and, in particular, to compositions of meat-free media.Type: ApplicationFiled: November 5, 2024Publication date: February 20, 2025Applicant: Inventprise, Inc.Inventors: Subhash V. Kapre, Seshu K. Gudlavalleti
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Publication number: 20240366743Abstract: The invention is directed to multivalent pneumococcal glycoconjugate compositions containing a newly emerging serotype of S. pneumonia, polysaccharide 24F, and their manufacture and use. The pneumococcal serotype 24F contains a polysaccharide repeating unit structure. The multivalent immunogenic composition comprises at least 25 S. pneumonia capsular polysaccharides selected from the serotypes 1, 2, 3, 4, 5, 6B, 6C, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15A, 15B, 15C, 16F, 17F, 18C, 19A, 19F, 20, 22F, 23B, 23F, 24F, 33F and 35B of S. pneumoniae preferably conjugated to carrier protein either directly or through a linker and a pharmaceutically acceptable carrier and/or adjuvant. The disclosure provides the capsular polysaccharide structure of serotype 24F to understand the polysaccharide before conjugation with carrier protein.Type: ApplicationFiled: July 19, 2024Publication date: November 7, 2024Applicant: Inventprise, Inc.Inventors: Subhash V. Kapre, Anup K. Datta
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Patent number: 12053515Abstract: The invention is directed to multivalent pneumococcal glycoconjugate compositions containing a newly emerging serotype of S. pneumonia, polysaccharide 24F, and their manufacture and use. The pneumococcal serotype 24F contains a polysaccharide repeating unit structure. The multivalent immunogenic composition comprises at least 25 S. pneumonia capsular polysaccharides selected from the serotypes 1, 2, 3, 4, 5, 6B, 6C, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15A, 15B, 15C, 16F, 17F, 18C, 19A, 19F, 20, 22F, 23B, 23F, 24F, 33F and 35B of S. pneumoniae preferably conjugated to carrier protein either directly or through a linker and a pharmaceutically acceptable carrier and/or adjuvant. The disclosure provides the capsular polysaccharide structure of serotype 24F to understand the polysaccharide before conjugation with carrier protein.Type: GrantFiled: August 10, 2021Date of Patent: August 6, 2024Assignee: Inventprise, Inc.Inventors: Subhash V. Kapre, Anup K. Datta
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Patent number: 11878054Abstract: The invention is directed to compositions and methods for the stabilization of viral and bacterial vaccines. Vaccines of the invention are contained in VLPs with stabilizing agents such as, for example, sugar alcohols (e.g., sorbitol) and degraded gelatins. Preferably the gelatin has an average molecular weight of 10,000 kilodaltons or less. These vaccines have a substantially improved thermostability as well as long term stability. The invention is also directed to the manufacture of a vaccine or the invention and methods for the administration of a vaccine of the invention to patients.Type: GrantFiled: August 9, 2020Date of Patent: January 23, 2024Assignee: Inventprise, Inc.Inventor: Subhash V. Kapre