Patents Assigned to Inventurous, LLC
  • Publication number: 20250041460
    Abstract: The present disclosure relates to pharmaceutical formulations of contrast agents used in magnetic resonance imaging (MRI) and methods of making and purifying the same. More specifically, disclosed are such pharmaceutical formulations of chelate complexes with lanthanide metal ions, such as gadolinium ions, as well as methods for obtaining and purifying the same. In particular, the pharmaceutical formulations are free or substantially free of water molecules coordinated with the lanthanide metal chelate complexes and provide pharmaceutical compositions that are more stable and release less lanthanide ion, specifically gadolinium ion, into the human body when injected as MRI contrast agents as compared to other typically used MRI contrast agents.
    Type: Application
    Filed: August 5, 2024
    Publication date: February 6, 2025
    Applicant: Inventure, LLC
    Inventors: Richard J. DESLAURIERS, Michael MILBOCKER, Paul LOMBARDO
  • Publication number: 20240189459
    Abstract: A method of preparing a stable lanthanide complex substantially free of metastable lanthanide complex and free lanthanide ion includes the steps of (i) complexing a macrocyclic chelator with a lanthanide metal in a suitable solvent to obtain a first solution of the metal complex, (ii) challenging the metal complex to cause metastable complexes to form free lanthanide ion and chelate to yield a second solution, and (iii) removing the free lanthanide ion from the second solution with a separation media.
    Type: Application
    Filed: December 12, 2023
    Publication date: June 13, 2024
    Applicant: Inventure LLC
    Inventors: Richard DESLAURIERS, Michael MILBOCKER, Paul LOMBARDO
  • Patent number: 11419953
    Abstract: Gadolinium based contrast agents (GCA) incorporating linear ligand chelation are fundamentally different from GCAs incorporating macrocyclic ligands. The macrocyclic\GCAs are synthesized by pathways characterized by the formation of a sequence of metastable complexes before obtaining the final stable complex. The synthesis of linear GCAs do not form metastable complexes. Commercial macrocyclic GCAs contain unstable metastable complexes. These metastable species are not regulated and quickly release free Gd3+ ions upon administration into the body. Gadolinium based contrast agents with near zero metastable species content and methods of synthesizing the same are disclosed. Gadolinium based contrast agents with long dissociation time in the body, and low free Gd3+ ion formation are obtained using a synthesis method which departs in novel ways from the traditional free Gd3+-based synthesis methods.
    Type: Grant
    Filed: November 23, 2021
    Date of Patent: August 23, 2022
    Assignee: Inventure, LLC
    Inventors: Richard Deslauriers, Michael Milbocker
  • Publication number: 20220242885
    Abstract: Macrocyclic gadolinium-based contrast agents (GCA) are synthesized by pathways characterized by the formation of a sequence of metastable complexes before obtaining the final stable complex. Commercial macrocyclic GCAs contain unstable metastable complexes. These metastable species quickly release free Gd3+ ions upon delivery into the body. Aqueous or dry/solid GCA with near zero metastable species content and methods of synthesizing the same are disclosed.
    Type: Application
    Filed: February 1, 2022
    Publication date: August 4, 2022
    Applicant: Inventure, LLC
    Inventors: Richard J. DESLAURIERS, Michael MILBOCKER, Paul LOMBARDO
  • Patent number: 10653804
    Abstract: Disclosed herein are complexes of gadolinium metal, ligand and meglumine that are substantially free of non-aqueous solvents. In particular, solvent-free complexes of 1) gadopentetate dimeglumine and 2) gadoterate meglumine are disclosed and methods of their preparation are disclosed. In addition, methods are disclosed for purifying reactants, monitoring and controlling pH, quantifying the free gadolinium content, quantifying the concentration of gadolinium-ligand complex in aqueous solution, and procedures for producing a drug product in one step. The one step process eliminates the need to dry the gadolinium-ligand complex, which is typically highly hygroscopic. The one step process includes purification steps that do not require the use of non-aqueous solvents.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: May 19, 2020
    Assignee: Inventure, LLC
    Inventors: Richard Deslauriers, Jonathan Balfour, Michael Milbocker
  • Patent number: 8689485
    Abstract: A vertical planter and gardening wall comprised of base planter blocks that are identical to each other and end blocks that are identical to each other. The blocks are stackable and interlock. The invention can be used by gardeners to cultivate and display their gardens indoors or outdoors in a restricted area.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: April 8, 2014
    Assignee: Inventurous, LLC
    Inventor: Jared Friedman
  • Publication number: 20130324009
    Abstract: The device includes an accelerometer for sensing movement in more than one direction, a sound chip for generating a pre-recorded sound in response to the sensed movement and a circuit for controlling the speed at which the pre-recorded sound is generated in response to the sensed movement, as a function of the direction of the sensed movement. The accelerometer senses the magnitude of movement. The sound chip generates sound in response to movement of a magnitude exceeding a pre-set level. The accelerator senses movement in at least two, preferably three directions. The sound chip includes an oscillator which determines the speed at which a pre-recorded sound is processed. The control means provides a control signal which sets the sound chip to generate the sound signal with a speed which is a function of the number of directions of sensed movement.
    Type: Application
    Filed: May 29, 2012
    Publication date: December 5, 2013
    Applicant: SynCon InVentures, LLC
    Inventor: Robert Pascale
  • Patent number: D645166
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: September 13, 2011
    Assignee: Inventurous, LLC
    Inventor: Jared Friedman
  • Patent number: D673341
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: December 25, 2012
    Assignee: WT Inventures, LLC
    Inventors: Scott H. Kline, Christine E. Rappolt
  • Patent number: D673342
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: December 25, 2012
    Assignee: WT Inventures, LLC
    Inventors: Scott H. Kline, Christine E. Rappolt
  • Patent number: D686524
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: July 23, 2013
    Assignee: Inventurous, LLC
    Inventor: Jared Friedman