Patents Assigned to Invitae Corporation
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Publication number: 20240006021Abstract: Disclosed herein are system, method, and computer program product embodiments for optimizing the determination of a phenotypic impact of a molecular variant identified in molecular tests, samples, or reports of subjects by way of regularly incorporating, updating, monitoring, validating, selecting, and auditing the best-performing evidence models for the interpretation of molecular variants across a plurality of evidence classes.Type: ApplicationFiled: September 14, 2023Publication date: January 4, 2024Applicant: Invitae CorporationInventors: Alexandre COLAVIN, Carlos L. ARAYA, Jason A. REUTER
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Patent number: 11798651Abstract: Disclosed herein are system, method, and computer program product embodiments for optimizing the determination of a phenotypic impact of a molecular variant identified in molecular tests, samples, or reports of subjects by way of regularly incorporating, updating, monitoring, validating, selecting, and auditing the best-performing evidence models for the interpretation of molecular variants across a plurality of evidence classes.Type: GrantFiled: September 16, 2022Date of Patent: October 24, 2023Assignee: Invitae CorporationInventors: Alexandre Colavin, Carlos L. Araya, Jason A. Reuter
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Patent number: 11761036Abstract: Provided herein are novel methods, systems and processes for generating and analyzing sequence data for the determination of the presence or absence of one or more genetic variations within a genome of a subject.Type: GrantFiled: March 29, 2021Date of Patent: September 19, 2023Assignee: INVITAE CORPORATIONInventors: Erik Gafni, Swaroop Aradhya, Leah Matzat, Eric Olivares, Vinayak Kulkarni, Joshua Paul
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Patent number: 11739371Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes. The invention also relates to manufacturing and using molecular arrays and analytical approaches based on single molecule detection techniques.Type: GrantFiled: February 18, 2016Date of Patent: August 29, 2023Assignee: Invitae CorporationInventors: Patrick James Collins, Adrian Nielsen Fehr, Jill Lyndon Herschleb, Hywel Bowden Jones
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Publication number: 20230187016Abstract: Disclosed herein are system, method, and computer program product embodiments for determining phenotypic impacts of molecular variants identified within a biological sample. Embodiments include receiving molecular variants associated with functional elements within a model system. The embodiments then determine molecular scores associated with the model system. The embodiments then determine molecular signals and population signals associated with the molecular variants based on the molecular scores. The embodiments then determine functional scores for the molecular variants based on statistical learning. The embodiments then derive evidence scores of the molecular variants based on the functional scores. The embodiments then determine phenotypic impacts of the molecular variants based on the functional scores or evidence scores.Type: ApplicationFiled: December 14, 2022Publication date: June 15, 2023Applicant: Invitae CorporationInventors: Carlos L. ARAYA, Jason A. REUTER, Samskruthi Reddy PADIGEPATI, Alexandre COLAVIN
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Patent number: 11667965Abstract: The invention relates to assembly of sequence reads. The invention provides a method for identifying a mutation in a nucleic acid involving sequencing nucleic acid to generate a plurality of sequence reads. Reads are assembled to form a contig, which is aligned to a reference. Individual reads are aligned to the contig. Mutations are identified based on the alignments to the reference and to the contig.Type: GrantFiled: February 13, 2020Date of Patent: June 6, 2023Assignee: Invitae CorporationInventors: Gregory Porreca, Caleb Kennedy
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Publication number: 20230117854Abstract: Disclosed herein are system, method, and computer program product embodiments for optimizing the determination of a phenotypic impact of a molecular variant identified in molecular tests, samples, or reports of subjects by way of regularly incorporating, updating, monitoring, validating, selecting, and auditing the best-performing evidence models for the interpretation of molecular variants across a plurality of evidence classes.Type: ApplicationFiled: September 16, 2022Publication date: April 20, 2023Applicant: Invitae CorporationInventors: Alexandre COLAVIN, Carlos L. ARAYA, Jason A. REUTER
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Patent number: 11610646Abstract: Provided herein are novel methods, systems and processes for mapping sequence reads to a modified reference genome and determining the presence or absence of a genetic variation, or the likelihood thereof, in a gene of interest in a subject.Type: GrantFiled: July 9, 2019Date of Patent: March 21, 2023Assignee: INVITAE CORPORATIONInventors: Daniel J. Kvitek, Erik Gafni
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Publication number: 20230002823Abstract: The invention relates to assembly of sequence reads. The invention provides a method for identifying a mutation in a nucleic acid involving sequencing nucleic acid to generate a plurality of sequence reads. Reads are assembled to form a contig, which is aligned to a reference. Individual reads are aligned to the contig. Mutations are identified based on the alignments to the reference and to the contig.Type: ApplicationFiled: July 18, 2022Publication date: January 5, 2023Applicant: Invitae CorporationInventors: Gregory PORRECA, Caleb KENNEDY
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Publication number: 20220340958Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: ApplicationFiled: May 9, 2022Publication date: October 27, 2022Applicant: Invitae CorporationInventors: Adrian Nielsen Fehr, Patrick Kames Collins, Jill Lyndon Herschleb, Hywel Bowden Jones
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Patent number: 11462299Abstract: Disclosed herein are system, method, and computer program product embodiments for optimizing the determination of a phenotypic impact of a molecular variant identified in molecular tests, samples, or reports of subjects by way of regularly incorporating, updating, monitoring, validating, selecting, and auditing the best-performing evidence models for the interpretation of molecular variants across a plurality of evidence classes.Type: GrantFiled: October 17, 2018Date of Patent: October 4, 2022Assignee: INVITAE CORPORATIONInventors: Alexandre Colavin, Carlos L. Araya, Jason A. Reuter
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Publication number: 20220298561Abstract: A method for quantifying labels on a substrate is performed by an electronic device with one or more processors and memory. The method includes obtaining digital data corresponding to a multi-dimensional measurement over the substrate; identifying a first set of sub-portions of the digital data; and, for a respective sub-portion of the first set of sub-portions of the digital data: increasing a quantity of labels, and subtracting a reference signal distribution from the respective sub-portion to obtain subtracted sub-portion data. The method also includes obtaining subtracted digital data. The subtracted digital data includes the subtracted sub-portion data for the respective sub-portion. The method further includes identifying a second set of one or more sub-portions of the subtracted digital data; and, for a respective sub-portion of the second set of one or more sub-portions of the subtracted digital data, increasing a quantity of labels.Type: ApplicationFiled: January 14, 2022Publication date: September 22, 2022Applicant: Invitae CorporationInventors: Hywel Bowden Jones, Andrea Lynn McEvoy
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SYSTEMS AND METHODS FOR QUANTIFICATION AND PRESENTATION OF MEDICAL RISK ARISING FROM UNKNOWN FACTORS
Publication number: 20220293235Abstract: Example methods of quantifying known and unknown risks of an adverse drug event in an individual based on various factors are disclosed. In some embodiments, factors include known drug-drug interactions and unknown phenotypes of cytochromes. Quantification may be based on severity of the adverse drug event/and or probability of occurrence in some embodiments. Example methods of displaying the quantified risk are also disclosed. In one embodiment, the risk of individuals is aggregated to display the risk of a population.Type: ApplicationFiled: April 8, 2022Publication date: September 15, 2022Applicant: Invitae CorporationInventors: Howard C. COLEMAN, Robert D. Patterson, Jessica Oesterheld, Rajeev V. Pany, Kristine Ashcraft -
Patent number: 11390919Abstract: The invention relates to assembly of sequence reads. The invention provides a method for identifying a mutation in a nucleic acid involving sequencing nucleic acid to generate a plurality of sequence reads. Reads are assembled to form a contig, which is aligned to a reference. Individual reads are aligned to the contig. Mutations are identified based on the alignments to the reference and to the contig.Type: GrantFiled: February 13, 2020Date of Patent: July 19, 2022Assignee: Invitae CorporationInventors: Gregory Porreca, Caleb Kennedy
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Patent number: 11326204Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.Type: GrantFiled: April 7, 2020Date of Patent: May 10, 2022Assignee: Invitae CorporationInventors: Adrian Nielsen Fehr, Patrick James Collins, Jill Lyndon Herschleb, Hywel Bowden Jones
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Systems and methods for quantification and presentation of medical risk arising from unknown factors
Patent number: 11302431Abstract: Example methods of quantifying known and unknown risks of an adverse drug event in an individual based on various factors are disclosed. In some embodiments, factors include known drug-drug interactions and unknown phenotypes of cytochromes. Quantification may be based on severity of the adverse drug event/and or probability of occurrence in some embodiments. Example methods of displaying the quantified risk are also disclosed. In one embodiment, the risk of individuals is aggregated to display the risk of a population.Type: GrantFiled: January 31, 2019Date of Patent: April 12, 2022Assignee: Invitae CorporationInventors: Howard C. Coleman, Robert D. Patterson, Jessica Oesterheld, Rajeev V. Pany, Kristine Ashcraft -
Publication number: 20220054060Abstract: This disclosure relates to a system and method for drawing blood from a user by skin puncture instead of venous puncture and storing it for analysis. The system includes a receptacle configured to engage an area of skin of the user at a blood draw location and store blood drawn from the user; a lancet device disposed within the receptacle configured to puncture the skin of the user at the blood draw location; a vacuum device configured to reduce a pressure within the receptacle such that the skin at the blood draw location is drawn into the receptacle before the lancet device punctures the skin, and to enhance blood flow while blood is drawn from the user; and a housing configured to house the receptacle, the lancet device, and the vacuum device. The receptacle, the lancet device, and the vacuum device may be modular and removably coupled with the housing.Type: ApplicationFiled: October 22, 2021Publication date: February 24, 2022Applicant: INVITAE CORPORATIONInventors: Sean Emerson GEORGE, Nathan MCDONALD, Eric OLIVARES, Robert EVANS
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Patent number: 11254973Abstract: A method for quantifying labels on a substrate is performed by an electronic device with one or more processors and memory. The method includes obtaining digital data corresponding to a multi-dimensional measurement over the substrate; identifying a first set of sub-portions of the digital data; and, for a respective sub-portion of the first set of sub-portions of the digital data: increasing a quantity of labels, and subtracting a reference signal distribution from the respective sub-portion to obtain subtracted sub-portion data. The method also includes obtaining subtracted digital data. The subtracted digital data includes the subtracted sub-portion data for the respective sub-portion. The method further includes identifying a second set of one or more sub-portions of the subtracted digital data; and, for a respective sub-portion of the second set of one or more sub-portions of the subtracted digital data, increasing a quantity of labels.Type: GrantFiled: September 1, 2017Date of Patent: February 22, 2022Assignee: Invitae CorporationInventors: Hywel Bowden Jones, Andrea Lynn McEvoy
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Patent number: 11166658Abstract: This disclosure relates to a system and method for drawing blood from a user by skin puncture instead of venous puncture and storing it for analysis. The system includes a receptacle configured to engage an area of skin of the user at a blood draw location and store blood drawn from the user; a lancet device disposed within the receptacle configured to puncture the skin of the user at the blood draw location; a vacuum device configured to reduce a pressure within the receptacle such that the skin at the blood draw location is drawn into the receptacle before the lancet device punctures the skin, and to enhance blood flow while blood is drawn from the user; and a housing configured to house the receptacle, the lancet device, and the vacuum device. The receptacle, the lancet device, and the vacuum device may be modular and removably coupled with the housing.Type: GrantFiled: July 27, 2017Date of Patent: November 9, 2021Assignee: INVITAE CORPORATIONInventors: Sean Emerson George, Nathan McDonald, Eric Olivares, Robert Evans
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Patent number: 11155863Abstract: The invention relates to assembly of sequence reads. The invention provides a method for identifying a mutation in a nucleic acid involving sequencing nucleic acid to generate a plurality of sequence reads. Reads are assembled to form a contig, which is aligned to a reference. Individual reads are aligned to the contig. Mutations are identified based on the alignments to the reference and to the contig.Type: GrantFiled: May 17, 2021Date of Patent: October 26, 2021Assignee: Invitae CorporationInventors: Gregory Porreca, Caleb Kennedy