Patents Assigned to Invitron Corporation
  • Novel antimicrobial peptide
    Patent number: 5032574
    Abstract: This invention provides a purified polypeptide useful as an antimicrobial agent. This purified polypeptide has been derived from human granulocytes, and has a molecular weight of about 3,700 daltons and the N-terminal amino acid sequence val-cys-ser-cys-arg-leu-val-phe-cys-arg-arg-thr-glu- leu-arg-val-gly-asn-cys-leu-ile-gly-gly-val-ser-phe-thr-try-cys-thr-arg-va l. This invention also provides methods for producing this polypeptide, pharmaceutical compositions containing the polypeptide, and uses thereof.
    Type: Grant
    Filed: May 26, 1988
    Date of Patent: July 16, 1991
    Assignee: Invitron Corporation
    Inventors: Craig G. Wilde, Joseph E. Griffith, Marian N. Marra, Randal W. Scott
  • Method to solubilize tissue plasminogen activator
    Patent number: 4898826
    Abstract: Practical amounts of tissue plasminogen activator (tPA) whether secreted by cells naturally producing it or prepared by recombinant means can be solubilized by providing, in aqueous medium at pH 5-14 8 a solubilizing amount of a basic amino acid optionally and preferably, in the presence of a citric acid moiety. The ability to solubilize tPA at concentrations of up to 50 mg is significant as an aid in permitting smaller volumes for purification and permitting single injections of the drug as opposed to intravenous administration.
    Type: Grant
    Filed: December 10, 1987
    Date of Patent: February 6, 1990
    Assignee: Invitron Corporation
    Inventors: Stephen A. Duffy, Christopher P. Prior, Randal W. Scott