Abstract: Systems and method for the management of biomarkers or biomarker associations subject to restricted access, such as by licensing fees, are provided. A license manager maintains license fee information on a number of biomarkers or biomarker associations. In one embodiment, a user may submit biological data for testing against one or more of the maintained biomarkers. The license manager determines which positive test results require use of licensed biomarkers or biomarker associations and may present this information to the user. In another embodiment, a set of biomarkers or biomarker associations may be submitted to determine if any biomarkers subject to license are included. The licensing manager determines whether licenses exist for included biomarkers and may return specific licensing information.