Abstract: The application relates to recombinant polypeptides having berberine bridge enzyme (BBE) activity that are derived from microorganisms, such as Phytohabitans sufuscus, Streptomyces sp. AJS327, Streptomyces varsoviensis, Actinomadura pelletieri, Streptomyces flaveolus, Streptomyces sp. Ru71. or Streptomyces sp. CNH287, and the use of these recombinant polypeptides in compositions and methods for the oxidative cyclization of prenylated compounds, such as CBGA, in carrying out the biosynthesis, including cell-free biosynthesis, of cyclized cannabinoid compounds, such as CBCA, THCA, and CBDA.
Type:
Application
Filed:
January 6, 2023
Publication date:
June 12, 2025
Applicant:
Invizyne Technologies, Inc.
Inventors:
Tyler KORMAN, John BILLINGSLEY, Mohammad HAYAT
Abstract: The present disclosure relates to compositions comprising cyclolavandulyl derivatives of aromatic compounds, such as cannabinoids, flavonoids, and alkaloids, and methods for preparing and using the compositions.
Type:
Application
Filed:
October 17, 2024
Publication date:
February 6, 2025
Applicant:
Invizyne Technologies, Inc.
Inventors:
John BILLINGSLEY, Tyler P. KORMAN, Mohammad HAYAT
Abstract: Systems and methods for prenylation and recombinant pathways for the production of compounds, cannabinoids, cannabinoid precursors, and other prenylated chemicals in a cell free system. The present invention further includes enzymes and recombinant microorganisms that catalyze the reaction. The compounds, cannabinoids, cannabinoid precursors, and other prenylated chemicals are operable to be substituted with at least one deuterium, at least one tritium, at least one halogen, at least one hydroxyl group, and/or at least one additional isotope.
Type:
Application
Filed:
July 28, 2023
Publication date:
March 7, 2024
Applicant:
Invizyne Technologies, Inc.
Inventors:
Tyler P. Korman, Bastian Vogeli, Andrew Lingard, Mohammad Hayat
Abstract: The present disclosure relates to recombinant prenyltransferase enzymes with increased thermostability and activity and the use of these enzymes in compositions and methods for biosynthesis involving prenylation reactions, including compositions and methods for the preparation of cannabinoids.