Abstract: The present invention relates to non-vaccinal and non-pharmacologic compositions and methods for controlling complex retroviral infections. In particular, the present invention provides transgenic animals expressing a transdominant negative Rex gene product that inhibits retroviral replication.
Type:
Grant
Filed:
January 23, 2004
Date of Patent:
November 27, 2007
Assignee:
ioGenetics, LLC
Inventors:
Kurt Eakle, Thomas Hope, Eun-A Choi, Jane Homan, Robert D. Bremel
Abstract: The present invention relates to retroviral constructs that encode novel monoclonal antibodies, novel fusion proteins, and chimeric monoclonal antibodies and to methods of using and producing the same. In particular, the present invention relates to methods of producing a fusion protein comprising a microorganism targeting molecule (e.g., immunoglobulin or innate immune system receptor molecule) and a biocide (e.g., bactericidal enzymes) in transgenic animals (e.g., bovines) and in cell cultures. The present invention also relates to therapeutic and prophylactic methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in health care (e.g., human and veterinary), agriculture (e.g., animal and plant production), and food processing (e.g., beef carcass processing).
Type:
Application
Filed:
May 13, 2004
Publication date:
January 20, 2005
Applicant:
IoGenetics, LLC
Inventors:
Michael Imboden, Jane Homan, Robert Bremel