Patents Assigned to Ionian Technologies, LLC
  • Nicking and extension amplification reaction (NEAR) of respiratory syncytial virus species
    Patent number: 11634770
    Abstract: This invention relates to methods and compositions for detecting the presence or absence of a Respiratory Syncytial Virus target nucleic acid in a biological sample using isothermal nucleic acid amplification.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: April 25, 2023
    Assignee: IONIAN TECHNOLOGIES, LLC
    Inventors: Honghua Zhang, Richard Roth
  • Nicking and extension amplification reaction (near) of species
    Patent number: 11186864
    Abstract: This invention relates to compositions, methods and kits for detecting the presence or absence of a bacterial species in a biological sample using isothermal nucleic acid amplification.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: November 30, 2021
    Assignee: IONIAN TECHNOLOGIES, LLC
    Inventors: Daiwei Shen, Richard Roth, Honghua Zhang
  • Nucleic acid amplifications
    Patent number: 10927393
    Abstract: A method includes combining a polynucleotide and an amplification reagent mixture to form a reaction mixture, wherein the reaction mixture comprises reversibly bound divalent ions in solution, and adjusting the pH of the reaction mixture to release the reversibly bound divalent ions, thereby initiating amplification of the polynucleotide.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: February 23, 2021
    Assignee: Ionian Technologies, LLC
    Inventors: Honghua Zhang, Jarrod Provins, Richard Roth
  • Nicking and extension amplification reaction for the exponential amplification of nucleic acids
    Patent number: 10851406
    Abstract: The invention is in general directed to the rapid exponential amplification of short DNA or RNA sequences at a constant temperature.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: December 1, 2020
    Assignee: Ionian Technologies, LLC
    Inventors: Brian K Maples, Rebecca C. Holmberg, Andrew P. Miller, Jarrod Provins, Richard Roth, Jeffrey Mandell