Abstract: An antimicrobial device which is adaptably affixable to a large variety of commercially available catheters. Preferably, the device employs a pair of metal ion emitting electrodes which are at least partially disposed within an insertion site of the catheter and which are pulsed with alternating potentials to electrolytically elute ions into surrounding tissue to build an antiseptic zone about the insertion site. The device comprises an insertion sleeve and associated jacket which is slidably affixable to the indwelling catheter and a self-contained battery power source and electronics unit. The unit supplies power for the electrolytic action and for electronics which time the period and width of potential signals for the electrolysis. Through alternate elution and deposition of ions back and forth between the electrodes, long term indwelling catheter efficacy is assured. Period activation also increases length of battery life.